Designing for crystalline form and crystalline physical properties: The roles of in-situ and ex-situ monitoring techniques

American Pharmaceutical Review

Volumn 5, Issue 2, 2002, Pages 46-54

  Dell'Orco, Philip ^a   Diederich, Ann M ^a   Rydzak, James W ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG;

ANALYTIC METHOD; ARTICLE; CHEMICAL PARAMETERS; CHEMICAL PROCEDURES; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; INFRARED SPECTROSCOPY; METHODOLOGY; PHASE TRANSITION; THERMODYNAMICS;

EID: 0036063803     PISSN: 10998012     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. "Vibrational Spectroscopy"
2. The application of Fourier-transform Raman spectroscopy to the analysis of pharmaceuticals and biomaterials
3. An Investigation of Solvent-Mediated Polymorphic Transformation of Progesterone Using in Situ Raman Spectroscopy
4. Nucleation, Growth, and Pseudo-Polymorphic Behavior of Citric Acid As Monitored in Situ by Attenuated Total Reflection Fourier Transform Infrared Spectroscopy
5. Monitoring pH Swing Crystallization of Nicotinic Acid by the Use of Attenuated Total Reflection Fourier Transform Infrared Spectrometry
6. Microprocessor control of sugar crystallization using refractive index and total density measurements
7. Light-scattering measurements to estimate kinetic parameters of crystallization
8. Study of ammonium chloride crystallization in a mixed vessel
9. Methane hydrate crystallization mechanism from in-situ particle sizing
10. Modeling and experimental analysis of PSD measurements through FBRM
11. The applicability of second harmonic generation for in situ measurement of induction time of selected crystallization systems
12. Particle-shape monitoring and control in crystallization processes
13. Characterization of particle size and its distribution during the crystallization of organic fine chemical products as measured in situ using ultrasonic attenuation spectroscopy
14. Crystallization Kinetics of Calcium Lactate in a Mixed-Suspension-Mixed-Product Removal Crystallizer
15. Nonlinear controller for batch crystallization: Development and experimental demonstration