A trans-dominant negative HIV type 1 Rev with intact domains of NLS/NOS and NES

AIDS Research and Human Retroviruses

Volumn 18, Issue 10, 2002, Pages 705-709

  Fang, Jianhua ^a   Kubota, Satoshi ^a   Pomerantz, Roger J ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMYLASPARTYLLEUCYLLEUCYLLYSYLALANYLVALYLARGINYLLEUCYLISOLEUCYLLYSYLPHEN YLALANYLLEUCYLTYROSYLGLUTAMINE; MUTANT PROTEIN; NUCLEAR EXPORT SIGNAL PEPTIDE; REV PROTEIN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; GENE CONSTRUCT; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; WILD TYPE;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CELL NUCLEOLUS; DIFFUSION; GENE PRODUCTS, REV; HIV CORE PROTEIN P24; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; RESPONSE ELEMENTS;

EID: 0036062282     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/088922202760072320     Document Type: Article

References (23)

1. Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA
2. The human immunodeficiency virus type 1 Rev protein: A pivotal protein in the viral life cycle
3. The HIV-1 Rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA
4. Cells non-productively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: A molecular model for latency
5. Sequence-specific RNA binding by the HIV-1 Rev protein
6. The ins and outs of HIV Rev
7. Rev protein and its cellular partners
8. The HIV-1 Rev protein
9. The amino terminal domain of HIV-1 Rev is required for discrimination of the RRE from nonspecific RNA
10. Mutational analysis of the human immunodeficiency virus type 1 Rev transactivator: Essential residues near the amino terminus
11. Functional dissection of the HIV-1 Rev trans-activator - Derivation of atrans-dominant repressor of Rev function
12. Real-time kinetics of HIV-1 Rev-Rev response element interactions. Definition of minimal binding sites on RNA and protein and stoichiometric analysis
13. A cis-acting peptide signal in human immunodeficiency virus type I Rev which inhibits nuclear entry of small proteins
14. The nuclear function of the nuclear diffusion inhibitory signal of human immunodeficiency virus type 1: Critical roles in dominant nuclear localization and intracellular stability
15. The Rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region
16. Sequence requirements for Rev multimerization in vivo
17. Dominant negative mutants of human T-cell leukemia virus type I Rex and human immunodeficiency virus type 1 Rev fail to multimerize in vivo
18. Trans-dominant inhibition of human immunodeficiency virus type 1 Rev occurs through formation of inactive protein complexes
19. Inhibition of HIV replication by capsid mutant C6b
20. Identification of trans-dominant HIV-1 Rev protein mutants by direct transfer of bacterially produced proteins into human cells
21. Solid-state NMR data support a helix-loop helix structural model for the N-terminal half of HIV-1 Rev in fibrillar form
22. Nucleocytoplasmic transport in human astrocytes: Decreased nuclear uptake of the HIV Rev shuttle protein
23. Inhibition of human immunodeficiency virus type 1 Rev function by a dominant-negative mutant of Sam68 through sequestration of unspliced RNA at perinuclear bundles