Studies on the pharmacokinetics of total and free valproate in mono- and bitherapy with carbamazepine in epileptic children and adolescents

Folia Neuropathologica

Volumn 40, Issue 2, 2002, Pages 97-100

  Steinborn, Barbara ^a   Galas Zgorzalewicz, Bozena ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Bitherapy; Monotherapy; Pharmacokinetic parameters; Valproic acid

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; VALPROIC ACID;

ADOLESCENT; ADOLESCENT DISEASE; ADULT; ARTICLE; CALCULATION; CHILD; CHILDHOOD DISEASE; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MONITORING; EPILEPSY; FOCAL EPILEPSY; GRAND MAL SEIZURE; HUMAN; MONOTHERAPY; PHARMACOLOGICAL PARAMETERS; STATISTICAL ANALYSIS; STEADY STATE;

EID: 0036060709     PISSN: 00283894     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Steady-state disposition of valproate and diffusional alone and coadministered to healthy volunteers
2. Changes in unbound and total valproic acid concentration after replacement of carbamazepine with oxcarbazepine
3. Clinical Pharmacokinetics of antiepileptic drugs in paediatric patients. Part I: Phenobarbital, Primidone, Valproic acid, Ethosuximide and Mesuximide
4. Pharmacokinetic properties of current antiepileptic drugs. What improvements are needed?
5. Valproic acid pharmacokinetics in children. IV. Effects of age and antiepileptic drugs on protein binding and intrinsic clearance
6. Antiepileptic Drug Pharmacokinetics and interactions: Impact on treatment of epilepsy
7. Concentration of carbamazepine and valproic acid in blood serum in children with seizures treated with mono or polytherapy
8. Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy
9. Clinical pharmacokinetics of carbamazepine and valproate in children and adolescents with epilepsy
10. The clinical relevance of serial determinations of plasma concentrations of carbamazepine and sodium valproate
11. Pharmacokinetics of free and total sodium valproate in adolescents and young adults during maintenance therapy
12. Pharmacokinetics of total and free valproic acid during monotherapy in infants
13. Adding valproate to lamotrigine: A study of their pharmacokinetic interaction
14. Binding parameters of valproic acid to serum protein in healthy adults at steady state
15. Can the serum protein binding of valproic acid limit the hepatic elimination?
16. No effect of gender or age on binding characteristics of valproic acid to serum proteins in pediatric patients with epilepsy
17. The effects of phenytoin and carbamazepine on serum concentrations of mono-unsaturated metabolites of valproic acid
18. Clinical utility of unbound antiepileptic drug blood levels in the management of epilepsy
19. Variability and clinical relevance of the interaction between sodium valproate and carbamazepine in epileptic patients
20. Antiepileptic drugs. A review of clinically significant drug interactions
21. Valproate population pharmacokinetics in children
22. Clinical and pharmacokinetic observations on Valproate - A 3-year follow-up study in 100 children with generalized epilepsy
23. Pharmacokinetics of total and free valproic acid during bitherapy with lamotrigine or vigabatrin in epileptic children and adolescents
24. Detection of carbamazepine-induced changes in valproic acid relative clearance in man by simple pharmacokinetic screening
25. Investigation of phenobarbital-carbamazepine-valproic acid interactions using population pharmacokinetic analysis for optimisation of antiepileptic drug therapy: An overview