Steady-state dispositions of valproate and diflunisal alone and coadministered to healthy volunteers

European Journal of Clinical Pharmacology

Volumn 56, Issue 9-10, 2000, Pages 715-721

  Addison, R S ^a   Parker Scott, S L ^a   Eadie, M J ^a   Hooper, W D ^a   Dickinson, R G ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Diflunisal; Glucuronidation; Valproate

Indexed keywords

2 PROPYL 2 PENTENOIC ACID; 2 PROPYL 4 PENTENOIC ACID; 3 OXOVALPROIC ACID; DIFLUNISAL; DRUG METABOLITE; NAVPA; UNCLASSIFIED DRUG; VALPROIC ACID; VALPROIC ACID GLUCURONIDE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BINDING SITE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISPOSITION; DRUG EFFECT; DRUG ELIMINATION; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG OXIDATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG URINE LEVEL; HUMAN; KIDNEY CLEARANCE; MALE; PRIORITY JOURNAL; STEADY STATE; VALIDATION PROCESS;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICONVULSANTS; AREA UNDER CURVE; BIOTRANSFORMATION; DIFLUNISAL; DRUG INTERACTIONS; GLUCURONIDES; HALF-LIFE; HUMANS; MALE; OXIDATION-REDUCTION; VALPROIC ACID;

EID: 0034467558     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280000211     Document Type: Article

References (27)

1. Quantitative metabolic profiling of valproic acid in humans using automated gas chromatographic/mass spectrometric techniques
2. Quantitative determination of valproic acid and 14 metabolites in serum and urine by gas chromatography/mass spectrometry
3. Urinary metabolites of valproic acid in epileptic patients
4. Aspects of dose-dependent metabolism of valproic acid
5. Apparent autoinduction of valproate β-oxidation in humans
6. Sodium valproate acutely inhibits lamotrigine metabolism
7. Pharmacokinetic interaction between zidovudine and valproic acid in patients infected with human immunodeficiency virus
8. The mechanism of carbamazepine-valproate interaction in humans
9. Panipenum, a carbapenem antibiotic, enhances the glucuronidation of intravenously administered valproic acid in rats
10. In vivo plasma protein binding interaction between valproic acid and naproxen
11. Displacement of valproic acid and carbamazepine from protein binding in normal and uremic sera by tolmetin, ibuprofen and naproxen: Presence of inhibitor in uremic serum that blocks valproic acid-naproxen interactions
12. Reactivity considerations in the analysis of glucuronide and sulfate conjugates of diflunisal
13. Pharmacokinetic interaction between indomethacin and difiunisal
14. The influence of diflunisal on the pharmacokinetics of oxazepam
15. Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs
16. Urinary excretion of valproate and some metabolites in chronically treated patients
17. Effect of felbamate on valproic acid disposition in healthy volunteers: Inhibition of β-oxidation
18. Reactivity considerations in the analysis of glucuronide and sulfate conjugates of diflunisal
19. Studies on the renal excretion of the acyl glucuronide, phenolic and sulphate conjugates of diflunisal
20. Effect of felbamate on the plasma protein binding of valproate
21. Effect of dose on the glucuronidation and sulfonation kinetics of difiunisal in man: Single dose studies
22. The effect of multiple dosage on the kinetics of glucuronidation and sulphation, of diflunisal in man
23. Variability in level dose ratio of valproate: Monotherapy versus polytherapy
24. Effects of probenecid on ketoprofen kinetics
25. Effect of probenecid on the formation and elimination of acyl glucuronides: Studies with zomepirac
26. Disposition and irréversible plasma protein binding of tolmetin in humans
27. Probenecid changes clearance of carprofen enantiomers: A preliminary study