Should a lower treatment line be used when treating paracetamol poisoning in patients with chronic alcoholism? A case against

Drug Safety

Volumn 25, Issue 9, 2002, Pages 625-632

  Dargan, Paul I ^a   Jones, Alison L ^a,b  

^a National Poisons Information Service   (United Kingdom)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALCOHOL; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; ISOENZYME; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL;

ALCOHOL CONSUMPTION; ALCOHOLISM; CHRONICITY; DISEASE PREDISPOSITION; DOSE CALCULATION; DOSE RESPONSE; DRUG INTOXICATION; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; LIVER TOXICITY; LONG TERM EXPOSURE; MEDICAL LITERATURE; METABOLITE; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SPECIES DIFFERENCE;

EID: 0036053479     PISSN: 01145916     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002018-200225090-00002     Document Type: Review

References (90)

1. Effects of legislation restricting pack sizes of paracetamol and salicylate on self-poisoning in the United Kingdom: Before and after study
2. Hepatotoxicity from paracetamol poisoning in western Sydney
3. Paracetamol overdose in a liver transplant centre: An 8-year experience
4. 2000 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System
5. Management of acute paracetamol poisoning
6. Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage
7. Cysteamine treatment in paracetamol overdose
8. Hepatotoxicity of paracetamol enhanced by ingestion of alcohol
9. Alcoholism, non-prescription drugs and hepatotoxicity: The risk from unknown acetaminophen ingestion
10. Elevated SGOT/SGPT ratio in alcoholic patients with acetaminophen hepatotoxicity
11. Nyquil and acute hepatic necrosis
12. Two cases of acute liver injury caused by ingesting small doses of acetaminophen
13. Severe liver damage following suicidal intake of paracetamol
14. Paracetamol medication and alcohol abuse: A dangerous combination for the liver and kidney
15. Clinical features of acetaminophen toxicity
16. Nyquil-associated liver injury
17. An autopsy case of acute hepatic failure caused by ingesting a small dose of acetaminophen in a drinker
18. Management of paracetamol poisoning complicated by enzyme induction due to alcohol or drugs
19. Orthotopic liver transplants necessitated by acetaminophen-induced hepatotoxicity
20. Acetaminophen treatment nomogram
21. Association of acetaminophen hepatotoxicity with fasting and ethanol use
22. Acetaminophen toxicity in an urban county hospital
23. Fulminant hepatic failure in acute acetaminophen overdose
24. Deaths from low dose paracetamol poisoning
25. Intravenous N-acetylcyteine: The treatment of choice for paracetamol poisoning
26. Management of anaphylactoid reactions to N-acetylcysteine
27. Adverse reaction to N-acetylcysteine during treatment for paracetamol poisoning
28. Adverse reactions to acetylcysteine and effects of overdose
29. Status epilepticus following intravenous N-acetylcysteine therapy
30. Death after N-acetylcysteine
31. Pharmacokinetics of N-acetylcysteine are altered in patients with chronic liver disease
32. Portal and systemic haemodynamic action of N-acetylcysteine in patients with stable cirrhosis
33. N-acetylcysteine acts as a potent peripheral vasodilator
34. Acetaminophen poisoning and toxicity
35. Acetaminophen overdose: A 48 hour intravenous N-acetylcysteine treatment protocol
36. Deaths from low dose paracetamol poisoning. Executive action is needed to change national guideline
37. Lower threshold has not yet overburdened hospital services in Gloucester
38. Paracetamol (acetaminophen) poisoning; No need to change current guidelines to accident departments
39. Recommendations for treatment of paracetamol poisoning. Danish Medical Society, Study of Liver
40. Recent advances in the management of late paracetamol poisoning
41. Acetaminophen poisoning and liver function
42. Evidence for the involvement of N-acetyl-p-benzoquinoneimine in acetaminophen metabolism
43. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism
44. Increased hepatotoxicity of acetaminophen after chronic ethanol consumption in the rat
45. Increased acetaminophen-induced hepatotoxicity after chronic ethanol consumption in mice
46. Interaction of acute ethanol administration with acetaminophen metabolism and toxicity in rats fed alcohol chronically
47. Interaction of ethanol with acetaminophen metabolism in the baboon
48. Effects of ethanol ingestion on the hepatotoxicity and metabolism of paracetamol in mice
49. Effects of ethanol ingestion on the metabolism of a hepatotoxic dose of paracetamol in mice
50. Modulation of cytochrome P450 isoenzymes in human liver, by ethanol and drug intake
51. Decrease in cytochrome P4502E1 as assessed by the rate of chlozoxazone hydroxylation in alcoholics during the withdrawal phase
52. Ethanol increases risk of acetaminophen hepatotoxicity in adults
53. Metabolic basis for high paracetamol dosage without hepatic injury: A case study
54. Is it safe to give acetaminophen to alcoholics? A metabolic study
55. Acetaminophen metabolism in patients with different cytochrome P-4502E1 genotypes
56. Cytochromes P450 2A6, 2E1 and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases
57. Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics
58. Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechl metabolited by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6
59. Presentation of poisoned patients to accident and emergency departments in the North of England
60. Paracetamol overdosage: Pharmacological considerations and clinical management
61. Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: A randomized, double-blind, placebo-controlled trial
62. Repeated supratherapeutic dosing of acetaminophen (apap): Can serum transaminase levels predict the risk of hepatotoxicity?
63. Routine screening for acetaminophen (APAP) toxicity of patients requesting alcohol detoxification
64. Pharmacokinetics amd metabolism of acetamnophen in normal, alcoholic amd cirrhotic subjects
65. Drug interactions affecting analgesic toxicity
66. Acetaminophen metabolism in recovering alcoholics
67. The effect of chronic alcohol intake on prognosis and outcome in paracetamol overdose
68. Analysis of factors responsible for continuing mortality after paracetamol overdose
69. A seven year experience of severe acetaminophen-induced hepatotoxicity (1987-1993)
70. Acetaminophen overdose. 662 Cases with evaluation of oral acetylcysteine treatment
71. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose: Analysis of the national multicenter study 1976-1985
72. Paracetamol hepatotoxicity and alcohol consumption in deliberate and accidental overdose
73. 'Late presenter' after paracetamol self-poisoning
74. Mechanisms of fasting-induced potentiation of acetaminophen hepatotoxicity in the rat
75. Ethanol suppresses hepatic glutathione synthesis in rats in vivo
76. Effect of ethanol on hepatotoxicity of acetaminophen in mice and on reactive metabolite formation by mouse and human liver microsomes
77. Toxicité du paracétamol chez la souris Swiss traitée par l'alcool éthylique en aigu ou à court terme
78. Effect of a concomitant single dose of ethanol on the hepatotoxicity in mice
79. Mechanism of the preventive effect of ethanol on acetaminophen-induced hepatotoxicity
80. The effect of alcohol on the toxicity of acetaminophen in mice
81. Ethanol protects from acetaminophen inducible hepatic necrosis by inhibiting its metabolic activation in mice
82. Prevention of acetaminophen-induced hepatotoxicity by acute ethanol administration in the rat: Comparison with carbon tetrachloride-induced hepatotoxicity
83. Mechanism by which ethanol diminishes the hepatotoxicity of acetaminophen
84. Inhibition of acetaminophen activation by ethanol and acetaldehyde in liver microsomes
85. Paracetamol, alcohol and the liver
86. The effect of mild alcohol consumption on the metabolism of acetaminophen in man
87. Does acute ethanol really protect against acetaminophen hepatotoxicity?
88. Is there a place for cimetidine or ethanol in the treatment of paracetamol poisoning?
89. Acetaminophen overdose
90. Acetaminophen overdose in young children: Treatment and effects of alcohol and other additional ingestants in 417 cases