An evaluation of the role of LIG4 in genomic instability and adaptive mutagenesis in Candida albicans

FEMS Yeast Research

Volumn 2, Issue 3, 2002, Pages 341-348

  Andaluz, Encarnación ^a   Ciudad, Toni ^a   Larriba, Germán ^a  

^a UNIVERSITY OF EXTREMADURA   (Spain)

Author keywords

Adaptive mutagenesis; Candida albicans; Genomic instability; LIG4

Indexed keywords

FLUOROOROTIC ACID; FUNGAL PROTEIN; PROTEIN LIG4; SORBOSE; UNCLASSIFIED DRUG; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE (ATP);

ARTICLE; CANDIDA ALBICANS; CELL TRANSFORMATION; CHROMOSOME ABERRATION; CHROMOSOME NUMBER; CONTROLLED STUDY; DNA RECOMBINATION; EVALUATION; FUNGUS MUTATION; GENE DISRUPTION; MOLECULAR STABILITY; MONOSOMY; NONHUMAN; PROTEIN FUNCTION; RECIPROCAL CHROMOSOME TRANSLOCATION; CHROMOSOME; CULTURE MEDIUM; GENE TRANSLOCATION; GENETIC RECOMBINATION; GENETICS; MUTAGENESIS; PHENOTYPE; PHYSIOLOGY; PULSED FIELD GEL ELECTROPHORESIS;

ANIMALIA; CANDIDA; CANDIDA ALBICANS;

CANDIDA ALBICANS; CHROMOSOMES, FUNGAL; CULTURE MEDIA; DNA LIGASES; ELECTROPHORESIS, GEL, PULSED-FIELD; MUTAGENESIS; PHENOTYPE; RECOMBINATION, GENETIC; TRANSLOCATION, GENETIC;

EID: 0036049780     PISSN: 15671356     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-1356(02)00094-6     Document Type: Article

References (37)

1. Virulence factors in Candida albicans
2. Candida albicans molecular biology reaches its maturity
3. The germ tubes of Candida albicans hyphae and pseudohyphae show different patterns of septin ring localization
4. The yeast Candida albicans has a clonal mode of reproduction in a population of infected human immunodeficiency virus-positive patients
5. High-frequency switching of colony morphology in Candida albicans
6. The emerging molecular biology of switching in Candida albicans
7. Monosomy of a specific chromosome determines L-sorbose utilization: A novel regulatory mechanism in Candida albicans
8. Variance of ploidy in Candida albicans
9. Loss of heterozygosity, by mitotic gene conversion and crossing over, causes strain-specific adenine mutants in constitutive diploid Candida albicans
10. Partners and pathways: Repairing a double-strand break
11. Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand repair and serves as a barrier to error-prone DNA repair pathways
12. Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae
13. The Saccharomyces cerevisiae Ku autoantigen homolog affects radiosensitivity only in the absence of homologous recombination
14. Cell-free V(D)J recombination
15. Cell cycle regulation of a DNA ligase-encoding gene (CaLIG4) from Candida albicans
16. Phenotypic analysis and virulence of Candida albicans LIG4 mutants
17. Multiple pathways of recombination induced by double strand breaks in Saccharomyces cerevisiae
18. A Candida albicans gene encoding a DNA ligase
19. The non-homologous DNA end joining pathway is important for chromosome stability in primary fibroblasts
20. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
21. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
22. Appearance and properties of L-sorbose utilizing mutants of Candida albicans obtained on a selective plate
23. Chromosomal alterations of Candida albicans are associated with the gain or loss of assimilating functions
24. Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development
25. Sequencing of a 4.3 kbp region of chromosome 2 of Candida albicans reveals the presence of homologues of SHE9 from Saccharomyces cerevisiae and a bacterial phosphatidylinositol-phospholipase C
26. Isogenic strain construction and gene mapping in Candida albicans
27. Specific alterations in fluconazol-resistant mutants of Candida albicans
28. Telomeric and dispersed repeat sequences in C. albicans yeast and their use in strain identification
29. Clonal variation of chromosome size derived from the rDNA cluster region of Candida albicans
30. Extensive chromosome translocation in a clinical isolate showing the distinctive carbohydrate assimilation profile from a candidiasis patient
31. Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae
32. Variation in chromosome size and organization in Candida albicans and Candida stellatoidea
33. Variations in the number of ribosomal DNA units in morphological mutants and normal strains of Candida albicans and in normal strains of Saccharomyces cerevisiae
34. The origin of mutants
35. Adaptive mutation: Has the unicorn landed?