A comparison of two different formulations of diclofenac sodium 0.1% in the treatment of inflammation following cataract-intraocular lens surgery

Drugs in R and D

Volumn 3, Issue 3, 2002, Pages 143-151

  Mester, Ulrich ^a   Lohmann, Chris ^b   Pleyer, U ^c   Steinkamp, G ^d   Volcker E ^e   Kruger, H ^f   Sunder Raj, Palaniswamy ^g  

^a Knappschaftskrankenhaus ^*  (Germany)

^b University of Eye Clinic   (Germany)

^c University Eye Clinic   (Germany)

^d UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^e UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^f RUHR UNIVERSITY BOCHUM   (Germany)

^g Novartis Ophthalmics AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BENZALKONIUM CHLORIDE; CORTICOSTEROID; DICLOFENAC; GAMMA CYCLODEXTRIN DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISOLONE ACETATE; SORBIC ACID; STEROID; THIOMERSAL; VOLTAREN OPHTHA; VOLTAREN OPHTHA CD; BENZALKONIUM;

ADULT; AGED; ANTERIOR EYE CHAMBER; ARTICLE; CATARACTOGENESIS; CLINICAL PROTOCOL; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; DRUG INSTILLATION; DRUG TOLERABILITY; DRUG TOLERANCE; EYE DISEASE; EYE INFLAMMATION; FEMALE; GERMANY; HUMAN; INFECTION SENSITIVITY; INTRAOCULAR HYPERTENSION; LASER FLARE CELL METER; LENS IMPLANTATION; MAJOR CLINICAL STUDY; MALE; PHACOEMULSIFICATION; POSTOPERATIVE CARE; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SURGICAL TECHNIQUE; VISUAL SYSTEM EXAMINATION; CATARACT EXTRACTION; CHEMISTRY; COMPARATIVE STUDY; INFLAMMATION; MIDDLE AGED; MULTICENTER STUDY; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; STATISTICS;

ADULT; AGED; AGED, 80 AND OVER; ANTERIOR CHAMBER; BENZALKONIUM COMPOUNDS; CATARACT EXTRACTION; CHEMISTRY, PHARMACEUTICAL; DICLOFENAC; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFLAMMATION; LENS IMPLANTATION, INTRAOCULAR; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; THIMEROSAL;

EID: 0036049242     PISSN: 11745886     EISSN: None     Source Type: Journal    
DOI: 10.2165/00126839-200203030-00001     Document Type: Article

References (27)

1. Havener WH. Ocular pharmacology. St Louis, CV Mosby, 1994, 408
2. Polansky JR. Side effects of topical ophthalmic therapy with anti-inflammatory steroids and beta-blockers. Curr Opin Ophthalmol 1992 April; 3 (2): 259-272
3. Ku EC, Lee W, Kothari HV, Scholer DW. Effect of diclofenac sodium on the arachidonic acid cascade. Am J Med 1986 April; 80 Suppl 4B: 18-23
4. Roberts CW, Brennan KM. A comparison of topical diclofenac with prednisolone for postcataract inflammation. Arch Ophthalmol 1995 June; 113 (6): 725-727
5. Stodtmeister R, Marquardt R. A non-steroidal inflammation inhibitor in chronic conjunctivitis. Fortschr Ophthalmol 1986; 83 (2): 199-202
6. Tauber J, Raizman MB, Ostrov CS, et al. A multi-center comparison of the ocular efficacy and safety of diclofenac 0.1% solution with that of ketorolac 0.5% solution in patients with acute seasonal allergic conjunctivitis. J Ocul Pharmacol Ther 1998 April; 14 (2): 137-145
7. Szucs PA, Nashed AH, Allegra JR, et al. Safety and efficacy of diclofenac ophthalmic solution in the treatment of corneal abrasions. Ann Emerg Med 2000 Feb; 35 (2): 131-7
8. Haynes RJ, Walker S, Kirkpatrick JNP. Topical diclofenac, relieves pain from corneal rust ring. Eye 1996; 10 (4): 443-6
9. Sichart U. Voltaren Ophtha sine eye drops in foreign body lesion and keratoconjunctivitis photoelectrica. Spektrum Augenheilkd 1995; 9 (6): 265-9
10. Sachdev MS, Singh K, Talwar D, et al. Comparative efficacy of diclofenac and flurbiprofen for maintenance of papillary dilatation during cataract surgery. Ophthalmic Surg 1994 Feb; 25 (2): 92-4
11. Tutton MK, Cherry PMH, Sunder Raj PS, Fsadni MG. Efficacy and safety of topical diclofenac in reducing ocular pain after excimer photorefractive keratectomy. J Cataract Refract Surg 1996 June; 22 (5): 536-541
12. Epstein RL, Laurence EP. Effect of topical diclofenac solution on discomfort after radial keratotomy. J Cataract Refract Surg 1994 July; 20 (4): 378-380
13. Morton NS, Benham SW, Lawson RA, et al. Diclofenac vs oxybuprocaine eye drops for analgesia in paediatric strabismus surgery. Paediatr Anaesth 1997; 7 (3): 221-6
14. Diestelhorst M, Thull D, Krieglstein GK. The effect of argon laser trabeculoplasty on the blood-aqueous barrier and intra-ocular pressure in human glaucomatous eyes treated with diclofenac 0.1%. Graefes Arch Clin Exp Ophthalmol 1995 Sept; 233 (9): 559-562
15. Othenin-Girard P, Tritten JJ, Pittet N, et al. Dexamethasone versus diclofenac sodium eye drops to treat inflammation after cataract surgery. J Cataract Refract Surg 1994 Jan; 20 (1): 9-12
16. Kraff MC, Martin RG, Neumann AC, Weinstein AJ. Efficacy of diclofenac sodium ophthalmic solution versus placebo in reducing inflammation following cataract extraction and posterior chamber lens implantation. J Cataract Refract Surg 1994 March; 20 (2): 138-144
17. Diestelhorst M, Schmidl B, Konen W, et al. Efficacy and tolerance of diclofenac sodium 0.1%, flurbiprofen 0.03%, and indomethacin 1.0% in controlling postoperative inflammation. J Cataract Refract Surg 1996; 22 Suppl. 1: 788-93
18. Demco TA, Sutton H, Demco CJ, Raj PS. Topical diclofenac sodium compared with prednisolone acetate after phacoemulsification-lens implant surgery. Eur J Ophthalmol 1997 July-Sept; 7 (3): 236-240
19. Lesnoni G, Coppe AM, Manni G, et al. Analgesic effect of topical diclofenac versus betamethasone after posterior segment surgery. Retina 1995; 15 (1): 34-6
20. Loftssona T, Jarvinen T. Cyclodextrins in ophthalmic drug delivery. Adv Drug Deliv Rev 1999 March; 36 (1): 59-79
21. Suhonen P, Jarvinen T, Lehmussaari K, Reunamaki T, Urtti A. Ocular absorption and irritation of pilocarpine prodrug is modified with buffer, polymer, and cyclodextrin in the eye drop. Pharm Res 1995 April; 12 (4): 529-533
22. Avci R, Erturk H, Ozcetin H. The effect of diclofenac sodium on postoperative inflammation. Eur J Implant Ref Surg 1993; 5 (1): 68-70
23. Loftsson T, Fridriksdottir H, Stefansson E, Thorisdottie S, Guomundsson O, Sigthorsson T. Topically effective ocular hypotensive acetazolamide and ethoxyzolamide formulations in rabbits. J Pharm Pharmacol 1994 June; 46 (6): 503-504
24. Reer O, Bock TK, Mueller BW. In vitro corneal permeability of diclofenac sodium in formulations containing cyclodextrins compared to commercial product voltaren ophtha. J Pharm Sci 1994 Sept; 83 (9): 1345-1349
25. Zemtsov A, Bolton GG. Thiomerosal-induced bullous contact dermatitis. Contact Dermatitis 1994 Jan; 30 (1): 57
26. Wilson-Holt N, Dart JKG. Thiomersal keratoconjunctivitis, frequency, clinical spectrum and diagnosis. Eye 1989; 3 (5): 581-7
27. Tosti A, Tosti G. Thiomerosal: a hidden allergen in ophthalmology. Contact Dermatitis 1988 May; 18 (5): 268-73