γ-adaptin appendage domain: Structure and binding site for Eps15 and γ-synergin

Structure

Volumn 10, Issue 8, 2002, Pages 1139-1148

  Kent, Helen M ^a   McMahon, Harvey T ^a   Evans, Philip R ^a   Benmerah, Alexandre ^b   Owen, David J ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b INSERM   (France)

Author keywords

Adaptin; Clathrin; Endosome; Golgi; Vesicle; synergin

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE 15; GAMMA ADAPTIN; GAMMA SYNERGIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; ADAPTOR PROTEIN; AP1GBP1 PROTEIN, HUMAN; AP1GBP1 PROTEIN, RAT; BREFELDIN A; CALCIUM BINDING PROTEIN; CARRIER PROTEIN; EPS15 PROTEIN, HUMAN; EPS15 PROTEIN, MOUSE; HYBRID PROTEIN; LIGAND; PHOSPHOPROTEIN; PROTEIN SYNTHESIS INHIBITOR; SIGNAL PEPTIDE;

ARTICLE; BINDING SITE; CELL MEMBRANE; CELL VACUOLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOSOME; GOLGI COMPLEX; HUMAN; HUMAN CELL; LIGAND BINDING; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HELA CELL; METABOLISM; MOLECULAR GENETICS; MOUSE; PROTEIN CONFORMATION; PROTEIN FOLDING; RAT; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

ADAPTOR PROTEIN COMPLEX 1; ADAPTOR PROTEIN COMPLEX GAMMA SUBUNITS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BREFELDIN A; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; GOLGI APPARATUS; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PHOSPHOPROTEINS; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN SYNTHESIS INHIBITORS; RATS; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT;

EID: 0036049039     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(02)00801-8     Document Type: Article

References (46)

1. The GGAs promote ARF-dependent recruitment of clathrin to the TGN
2. Sorting of mannose 6-phosphate receptors mediated by the GGAs
3. The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein
4. Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor
5. Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis
6. Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes
7. A clathrin-binding site in the hinge of the beta 2 chain of mammalian AP-2 complexes
8. Clathrin interactions with C-terminal regions of the yeast AP-1 beta and gamma subunits are important for AP-1 association with clathrin coats
9. Interaction of tyrosine-based sorting signals with clathrin-associated proteins
10. A functional phosphatidylinositol 3,4,5-trisphosphate/phosphoinositide binding domain in the clathrin adaptor Ap-2 alpha subunit - Implications for the endocytic pathway
11. Adaptors for clathrin-mediated traffic
12. Adaptor-related proteins
13. Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus
14. Structural relationships between clathrin assembly proteins from the Golgi and the plasma membrane
15. In polarized MDCK cells basolateral vesicles arise from clathrin-gamma-adaptin-coated domains on endosomal tubules
16. 100-kD coated vesicle proteins: Molecular heterogeneity and intracellular distribution studied with monoclonal antibodies
17. A structural explanation for the recognition of tyrosine-based endocytotic signals
18. Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site
19. Medium chains of adaptor complexes ap-1 and ap-2 recognize leucine-based sorting signals from the invariant chain
20. Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin
21. Association of the AP-3 adaptor complex with clathrin
22. Gamma subunit of the AP-1 adaptor complex binds clathrin: Implications for cooperative binding in coated vesicle
23. The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps15 protein
24. Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis
25. A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain
26. The structure and function of the beta2-adaptin appendage domain
27. A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals
28. Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly
29. Gamma-synergin: An EH domain-containing protein that interacts with gamma-adaptin
30. Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin
31. A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome
32. Gga's:a family of adp ribosylation factor-binding proteins related to adaptors and associated with the golgi complex
33. Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits
34. Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalization
35. Recruitment of coat proteins onto Golgi membranes in intact and permeabilized cells: Effects of brefeldin A and G protein activators
36. Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain
37. Adaptins: The final recount
38. The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein
39. The EH network
40. Recent changes to the MOSFLM package for processing film and image plate data
41. The CCP4 suite: Programs for protein crystallography
42. Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods
43. Methods used in the structure determination of bovine mitochondrial F1 ATPase
44. Improved methods for building protein models in electron density maps and the location of errors in these models
45. Refinement of macromolecular structures by the maximum-likelihood method
46. Recruitment of activated G protein-coupled receptors to pre-existing clathrin-coated pits in living cells