A broader horizon of Alzheimer pathogenesis: ALZAS - An early serum biomarker?

Journal of Neural Transmission, Supplement

Volumn , Issue 62, 2002, Pages 87-95

  Kienzl, E ^a   Jellinger, K ^a,e   Janetzky, B ^b   Steindl, H ^c   Bergmann, J ^d  

^a LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^c UNIVERSITY OF AGRICULTURAL SCIENCES   (Austria)

^d ALTEGEN Inc   (Germany)

^e INSTITUTE OF CLINICAL NEUROBIOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTIBODY; EPITOPE; GENE PRODUCT; PROTEIN ALZAS; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); BIOLOGICAL MARKER; PEPTIDE FRAGMENT;

ALLELE; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; CARBOXY TERMINAL SEQUENCE; CHROMOSOME 21; CONFERENCE PAPER; CONTROLLED STUDY; DEPRESSION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; INTRON; LEUKOCYTE; PATHOGENESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; AGED; AGING; ARTICLE; BLOOD; BRAIN LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; IMMUNOLOGY; MOLECULAR GENETICS; PATHOLOGY;

AGED; AGING; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANTIBODIES; BIOLOGICAL MARKERS; BRAIN CHEMISTRY; CHROMOSOMES, HUMAN, PAIR 21; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS;

EID: 0036047750     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6139-5_9     Document Type: Conference Paper

References (23)

1. Bullido M, Munoz-Fernandez MA, Recuero M, Fresno M, Valdivieso F (1996) Alzheimer's amyloid precursor pprotein is expressed on the surface of hematopoietic cells upon activation. Biochim Biophys Acta 1313: 54-62
2. Butterfield DA, Drake J, Pocernich C, Castegna A (2001) Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide. TIMM 7: 548-554
3. Evenhuis HM (1997) The natural history of dementia in ageing people with intellectual disability. J Intellect Disabil Res 41: 92-96
4. Geerlings MI, Schoevers RA, Beekman AT, Jonker C, Deeg DJ, Schmand B, Ader HJ, Bouter LM, Van Tilburg W (2000) Depression and risk of cognitive decline and Alzheimer's disease. Results of two prospective community-based studies in The Netherlands. Br J Psychiatry 176: 568-75
5. Ikin AF, Annaert WG, Takei K, De Camilli P, Jahn R, Greengard P, Buxbaum JD (1996) Alzheimer amyloid protein precursor is localizsed in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway. J Biol Chem 271: 31783-31786
6. Jellinger KA, Rosier N (2000) Neuropathology and biological markers of degenerative dementias. Internist 41: 524-537
7. Kokmen E, Beard CM, Chandra V, Offord KP, Schoenberg BS, Ballard DJ (1991) Clinical risk factors for Alzheimer's diseasee: a population-based case-control study. Neurology 41: 1393-1397
8. Koudinov A, Matsubara E, Frangione B, Ghiso J (1994) The soluble form of Alzheimer's amyloid beta protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma. Biochem Biophys Res Commun 205: 1164-1171
9. Li QX, Fuller StJ. Beyreuther K, Masters CL (1999) The amyloid precursor protein of Alzheimer disease in human brain and blood. J Leuk Bio 66: 567-574
10. Lin H, Bhatia R, Lal R (2001) Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathology. FASEB J 15: 2433-2444
11. McGeer PI, McGeer EG, Yasojima K (2000) Alzheimer disease and neuroinflammation. J Neural Transm [Suppl] 59: 53-57
12. Mirra SS, Hart MN, Terry RD (1993) Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists. Arch Pathol Lab Med 117: 132-144
13. Parvathy S, Davies P, Haroutunian V, Purohit DP, Davis KL, Mohs RC, Park H, Moran TM, Chan JY, Buxbaum JD (2001) Correlation between Aβx-40-, Aβx-42-, and Aβx-43-containing amyloid plaques and cognitive decline. Arch Neurol 58: 2025-2032
14. Pimplikar SW (2002) AβPP, apoptosis and Alzheimer's disease. J Alzheimer Dis 4: 39-40
15. Qiu WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ (1995) Cell-surface β-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. J Neurosci 15: 2157-2167
16. 2+-sensitive channel. J Biol Chem 273: 13379-13382
17. Saunders AM (2000) Apolipoprotein E and Alzheimer disease: an update on genetic and functional analyses. J Neuropathol Exp Neurol 59: 751-758
18. Selkoe DJ (2000) The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins. Neurol Clin 18: 903-922
19. Selkoe DJ (2001) Clearing the brain's amyloid cobwebs. Neuron 32(2): 177-180
20. Strohmeyer R, Rogers J (2001) Molecular and cellular mediators of Alzheimer's disease inflammation. J Alzheimer Dis 3: 131-157
21. The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group (1998) Consensus report of the Working Group on "Molecular and biochemical markers of Alzheimer disease". Neurobiol Aging 19: 109-116
22. Wilson CA, Doms RW, Lee VM (1999) Intracellular APP processing and A beta production in Alzheimer disease. J Neuropathol Exp Neurol 58: 787-794
23. Wisniewski HM and Wegiel J (1994) β-amyloid formation by myocytes of leptomeningeal vessels. Acta Neuropathol 87: 233-241