Is there a relationship between in vitro drug resistance and level of minimal residual disease as detected by polymerase chain reaction at the end of induction therapy in childhood acute lymphoblastic leukaemia? [1]

British Journal of Haematology

Volumn 118, Issue 4, 2002, Pages 1190-1191

  De Haas, V ^a   Kaspers, G J L ^c   Oosten, L ^b   Bresters, D ^c   Pieters, R ^e   Van Der Velden, V H J ^d   Van Wering, E R ^f   Van Den Berg, H ^a,f   Van Der Schoot, C E ^a,b  

^a EMMA CHILDREN S HOSPITAL   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^e SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^f Dutch Childhood Leukemia Study Group   (Netherlands)

Author keywords

Drug resistance; MRD; MTT assay; RQ PCR

Indexed keywords

ASPARAGINASE; DAUNORUBICIN; DEXAMETHASONE; PREDNISOLONE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ASSAY; BONE MARROW BIOPSY; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DRUG RESPONSE; DRUG SENSITIVITY; HIGH RISK POPULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IN VITRO STUDY; LC 50; LETTER; LEUKEMIA CELL; MINIMAL RESIDUAL DISEASE; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RELAPSE; TREATMENT OUTCOME;

CHILD; DRUG RESISTANCE, NEOPLASM; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; NEOPLASM, RESIDUAL; POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC; TUMOR CELLS, CULTURED;

EID: 0036042599     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.36211.x     Document Type: Letter

References (7)

1. Quantification of minimal residual disease in children with oligoclonal B-precursor ALL indicates that the clones that grow out during relapse have the slowest rate of reduction already during induction therapy
2. In vitro cellular drug resistance and prognosis in newly diagnosed childhood acute lymphoblastic leukemia
3. Prednisolone resistance in childhood acute lymphoblastic leukemia: Vitro-vivo correlations and cross-resistance to other drugs
4. Post-induction residual leukemia in childhood ALL quantified by PCR correlates with in vitro prednisolone resistance
5. Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995
6. Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood
7. Application of germline IGH probes in real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia