Characterization of the hypotensive effect of S-nitroso-N-acetylcysteine in normotensive and hypertensive conscious rats

Nitric Oxide - Biology and Chemistry

Volumn 7, Issue 1, 2002, Pages 57-66

  Ricardo, Kelly Fabiane Santos ^a   Shishido, Sílvia Mika ^a   De Oliveira, Marcelo Ganzarolli ^a   Krieger, Marta Helena ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Hypertensive rats; Hypotensive effect; NO release; S Nitrosothiols; Sodium nitroprusside; Transnitrosation

Indexed keywords

ANTIHYPERTENSIVE AGENT; N ACETYL S NITROSOCYSTEINE; NITROPRUSSIDE SODIUM; UNCLASSIFIED DRUG; VASODILATOR AGENT; ACETYLCYSTEINE; CYCLIC GMP; DRUG DERIVATIVE; S-NITROSO-N-ACETYLCYSTEINE; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DECOMPOSITION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SOLUBILITY; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION; ANIMAL; BLOOD PRESSURE; DRUG COMBINATION; DRUG POTENTIATION; DRUG STABILITY; METABOLISM; WISTAR RAT;

ANIMALIA;

ACETYLCYSTEINE; ANIMALS; BLOOD PRESSURE; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; HYPERTENSION; MALE; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS; VASODILATION;

EID: 0036041969     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1089-8603(02)00009-5     Document Type: Article

References (57)

1. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprus-side and nitric oxide: Evidence for the involvement of S-nitrosothiol active intermediates
2. Biological activity of S-nitrosothiols: The role of nitric oxide
3. Inhibition of human-platelet aggregation by S-nitrosothiols-heme-dependent activation of soluble guanylate-cyclase and stimulation of cyclic-GMP accumulation
4. S-nitroso-glutathione inhibits platelet activation in vitro and in vivo
5. S-nitrosothiols: A class of nitric oxide-donor drugs
6. A novel family of S-nitrosothiols: Chemical synthesis and biological action
7. Chemical mechanisms underlying the vasodilator and platelet anti-aggregating properties of S-nitroso-N-acetyl-DL-penicillamine and S-nitrosoglutathione
8. Activation of soluble guanylyl cyclase by the nitrovasodilator 3-morpholinosydnonimine involves formation of S-nitrosoglutathione
9. Kinetics equilibria of S-nitrosothiol-thiol exchange between glutathione, cysteine, penicillamine and serum albumin
10. S-Transnitrosation reactions are involved in the metabolic fate and biological actions of nitric oxide
11. The antioxidant action of N-acetylcysteine - Its reaction with hydrogen-peroxide, hydroxyl radical, superoxide, and hypochlorous acid
12. The antithrombotic effect of organic nitrates
13. Thiols and nitrates: Reevaluation of the thiol depletion theory of nitrate tolerance
14. Metal ion catalysis in nitrosothiol (RSNO) decomposition
15. The chemistry of S-nitrosothiols
16. The mechanism of photochemical release of nitric oxide from S-nitrosoglutathione
17. Poly(ethylene glycol) matrix reduces the rates of photochemical and thermal release of nitric oxide from S-nitroso-N-acetylcysteine
18. Spontaneous liberation of nitric oxide cannot account for in vitro vascular relaxation by S-nitrosothiols
19. Biological activity of S-nitrosothiols: The role of nitric oxide
20. Comparison of the pharmacological profile of S-nitrosothiols, nitric oxide and the nitrergic neurotransmitter in the canine ileocolonic junction
21. Nitric oxide and thiol groups
22. Dynamic state of S-nitrosothiols in human plasma and whole blood
23. Modification of creatine kinase by S-nitrosothiols: S-nitrosation vs S-thiolation
24. Cell-surface protein disulfide isomerase catalyzes transnitrosation and regulates intracellular transfer of nitric oxide
25. Recent chemical studies of sodium nitroprusside relevant to its hypotensive action
26. Nitric oxide generation from nitroprusside by vascular tissue. Evidence that reduction of the nitroprusside anion and cyanide loss are required
27. Cyanonitrosylmetallates as potential NO-donors
28. Photosensitivity of aqueous sodium nitroprusside solutions: Nitric oxide release versus cyanide toxicity
29. S-nitrosothiols do not induce oxidative stress, contrary to other nitric oxide donors, in cultures of vascular endothelial or smooth muscle cells
30. Tolerance to relaxation in rat aorta: Comparison of a S-nitrosothiol with nitroglycerin
31. S-Nitrosothiols as vasodilators: Implications regarding tolerance to nitric oxide-containing vasodilators
32. 2 reaction
33. The mechanism of nitric oxide formation from S-nitrosothiols (thionitrites)
34. Mechanism of nitric oxide release from S-nitrosothiol
35. S-nitrosothiols: Materials, reactivity and mechanisms
36. Improved methods to measure end products of nitric oxide in biological fluids: Nitrite, nitrate, and S-nitrosothiols
37. Nitric oxide circulates in mammalian plasma primarily as a S-nitroso adduct of serum albumin
38. Nitrosothiol quantification in human plasma
39. Effect of thiol status on nitric oxide metabolism in the circulation
40. Reductive assays for S-nitrosothiols: Implication for measurements in biological systems
41. 2- ion in water and poly(vinyl alcohol) films: Evidence for cyano radical, cyanide ion and nitric oxide loss and redox pathways
42. Increased systemic vascular resistance and primary hypertension: The expanding complexity
43. Role of vascular nitric oxide in physiological and pathological conditions
44. Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension
45. Role of superoxide in the depressed nitric oxide production by the endothelium of genetically hypertensive rats
46. In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats: Hydroethidine microfluorography
47. Chronic inhibition of nitric oxide synthesis: A new model of arterial hypertension
48. Nitric oxide, - Pathophysiological mechanisms
49. Transplasma - Membrane redox systems in growth and development
50. Transnitrosation as a predominant mechanism in the hypotensive effect of S-nitroso-glutathione
51. In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols
52. Mechanistic information from medium and high-pressure effects on the photooxidation of nitrosylpentacyanoferrate (II)
53. Kinetics and mechanisms of some substitution reaction of pentacyanoferrate (III) complexes
54. Interaction of glyceryl trinitrate and sodium nitroprusside with bovine pulmonary vein homogenate and 10,000 × g supernatant: Biotransformation and nitric oxide formation
55. Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle
56. The reaction of cysteine with pentacyanonitrosylferrate (2-) ion
57. 3- complex: A mechanistic study