Use of a non-depleting anti-CD4 antibody to modulate the immune response to coagulation factors VIII and IX

British Journal of Haematology

Volumn 118, Issue 3, 2002, Pages 839-842

  Salooja, Nina ^a,b   Kemball Cook, Geoffrey ^a   Tuddenham, Edward G D ^a   Dyson, Julian ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

Haemophilia A and B; Non depleting anti CD4 antibody; Peripheral immune tolerance

Indexed keywords

AUTOANTIBODY; BLOOD CLOTTING FACTOR 8 ANTIBODY; BLOOD CLOTTING FACTOR 9 ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; OKT 4; RECOMBINANT BLOOD CLOTTING FACTOR 8; RECOMBINANT BLOOD CLOTTING FACTOR 9; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; AUTOANTIBODIES; FACTOR IX; FACTOR VIII; FEMALE; IMMUNE TOLERANCE; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED CBA; RECOMBINANT PROTEINS;

EID: 0036041476     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.03666.x     Document Type: Article

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4. Tolerance to heart and kidney grafts induced by nondepleting anti-CD4 monoclonal antibody (RIB 5/2) versus depleting anti-CD4 monoclonal antibody (OX-38) with donor antigen administration
5. Prevention and treatment of factor VIII inhibitors in murine hemophilia A
6. CD4 monoclonal antibody pairs for immunosuppression and tolerance induction
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8. Maintenance of in vivo tolerance by persistence of antigen
9. Cytotoxic T lymphocyte - Associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation
10. Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen
11. Transplantation tolerance - Where do we stand?
12. Anti-CD4 monoclonal antibodies suppress murine collagen-induced arthritis only at the time of primary immunisation