Preferential survival of an MBP-specific T cell clone in an HLA-DR2 multiple sclerosis patient

NeuroImmunoModulation

Volumn 10, Issue 1, 2002, Pages 1-4

  Demoulins T ^a   Naccache, L ^a   Clayette, P ^a   Musette, P ^c   Bequet, D ^b   Gachelin, G ^c   Dormont, Dominique ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^b University of Paris Descartes   (France)

^c INSTITUT PASTEUR   (France)

Author keywords

Multiple sclerosis; Myelin basic protein; T cell clone

Indexed keywords

HLA DR2 ANTIGEN; MYELIN BASIC PROTEIN; NUCLEOTIDE; PEPTIDE; POLYAMINOACID;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CASE REPORT; CELL CLONE; CELL CULTURE; CEREBROSPINAL FLUID; HUMAN; IMMUNOREACTIVITY; LYMPHOCYTE PROLIFERATION; MALE; METHODOLOGY; MULTIPLE SCLEROSIS; NUCLEOTIDE SEQUENCE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; AMINO ACID SEQUENCE; AUTOANTIBODIES; CELL SURVIVAL; CELLS, CULTURED; CLONE CELLS; HLA-DR2 ANTIGEN; HUMANS; MALE; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEINS; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-CELL ANTIGEN RECEPTOR SPECIFICITY; T-LYMPHOCYTES;

EID: 0036040842     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000064414     Document Type: Article

References (4)

1. The immunoscope approach repertoires
2. Expansion of a recurrent V beta 5.3+ T-cell population in newly diagnosed and untreated HLA-DR2 multiple sclerosis patients
3. A common TCR V-D-J sequence in V beta 13.1 T cells recognizing an immunodominant peptide of myelin basic protein in multiple sclerosis
4. Limited restriction in the TCR-alpha beta V region usage of antigen-specific clones. Recognition of myelin basic protein (amino acids 84-102) and Mycobacterium bovis 65-kDa heat shock protein (amino acids 3-13) by T cell clones established from peripheral blood mononuclear cells of monozygotic twins and HLA-identical individuals