Effects of drug treatment on bone strength and structural changes with aging: An experimental study in rats

Journal of Orthopaedic Science

Volumn 7, Issue 5, 2002, Pages 544-548

  Takee, Atsushi ^a   Hirano, Jun ^a   Uchikura, Chozo ^a   Ohmori, Shigeki ^a   Kodera, Masazumi ^a   Kotani, Akihiro ^a   Ishii, Yoshiaki ^a   Nakahara, Hiroyuki ^b  

^a KYORIN UNIVERSITY   (Japan)

^b Nakahara Seikeigekaiin   (Japan)

Author keywords

Bone strength test; Growing rats; Microcomputed tomography

Indexed keywords

CALCIUM; VITAMIN D; VITAMIN K GROUP;

AGE; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE STRENGTH; BONE STRUCTURE; CHILD GROWTH; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIETARY INTAKE; EVALUATION; FEMALE; FEMUR; FEMUR CONDYLE; FRACTURE; JOINT LIMITATION; MICROSCOPIC ANATOMY; NONHUMAN; OSTEOPOROSIS; STATISTICAL SIGNIFICANCE; TRABECULAR BONE; VITAMIN SUPPLEMENTATION;

EID: 0036033690     PISSN: 09492658     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007760200097     Document Type: Article

References (20)

1. Akiyama Y, Hara K, Ohkawa I, et al. Effects of Menatetrenone on bone loss induced by ovariectomy in Rats. Jpn J Pharmacol 1993;62:145-53.
2. 2 (Menatetrenone) on bone resorption in ovariecto-mized rats: A histomorphometric and dual energy x-ray absorptio-metric study. Jpn J Pharmacol 1999;80:67-74.
3. Ebbesen EN, Thomsen JS, Beck-Nielsen H, et al. Age- and gender-related differences in vertebral bone mass, density, and strength. J Bone Miner Res 1999;14(8):1394-1403.
4. Fujita T, Okamura H. Evaluation of quantity of bone and bone strength of experiment osteoporosis. Clin Calcium 1994;4(10):18-23.
5. Fukuda S, Iida H. Changes in bone metabolism in male and female rats with aging and differential effects of age of ovariectomy or testectomy. Jpn Soc Bone 1991;1:89-94.
6. 3 on bone loss in ovariectomized rats. Folia Pharmacol Jpn 2001;118:231-40.
7. Higuchi Y, Sato K, Nanjo M, et al. Bone improving effect of 1α-hydroxycholecarciferol on rats undergoing ovariectomy. Vitamins 1994;68(2):87-93.
8. Hirota T, Hirota K. Diet therapy of osteoporosis. Clin Nutr 2001;99(3):290-7.
9. Iida M. Mechanical tests for bone, cartilage and soft tissues. Orthop Surg Traumatol 1983;26(10):1493-1503.
10. Ito M, Tsurusaki K, Hayashi K. Evaluation by quantitative CT. Clin Calcium 1997;7(10):14-20.
11. Kamezawa K. Inhibitory effect of combined treatment with vitamin K and D on bone loss of ovariectomized rats: A microradiographic study. Fukuoka Acta Med 1999;90(3):71-8.
12. Kiyono Y. The importance of peak bone mass for the prevention of osteoporosis. Osteoporosis Japan 1997;5:71-2.
13. Kodera M. Age-related changes, in bone mineral density and strength in Wistar rats. Journal of the Eastern Japan Association of Orthopaedics and Traumatology 1997;9:103-8.
14. Matsunaga S, Ito H, Sakou T. The effect of vitamin K and D supplementation on ovariectomy-induced bone loss. Calcif Tissue Int 1999;65:285-9.
15. 2 on bone microarchitecture in ovariectomized rats. Kidney Metab Bone Dis 2001;14(4):303-8.
16. Mosekilde L, Mosekilde L, Danielsen CC. Biomechanical competence of vertebral trabecular bone in relation to ash density and age in normal individuals. Bone 1987;8:79-85.
17. Nakahara H. The effect of sodium fluoride on bone mineral density and bone strength in ovariectomized rats. J Jpn Orthop Assoc 1995;69:1182-92.
18. Sato K, Yoshinobu H. Pathology of rats undergoing ovariectomy and fed calcium-restricted diet. Clin Calcium 1994;4(10):46-9.
19. Tanizawa T. Bone strength and bone mineral content. Kidney Metab Bone Dis 2000;13:209-14.
20. Uchiyama T. Evaluation of fine structure of bone using μCT. Clin Calcium 1997;7(10):64-5.