Nitric oxide synthase inhibition and glutamate binding in quinolinate-lesioned rat hippocampus

Physiological Research

Volumn 51, Issue 3, 2002, Pages 299-307

  Lisý, Václav ^a,b   Stastny F ^a  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (Czech Republic)

Author keywords

Membrane binding; Neurodegeneration; Nitric oxide synthase (NOS); NMDA receptor; Quinolinic acid

Indexed keywords

4 (3 PHOSPHONOPROPYL) 2 PIPERAZINECARBOXYLIC ACID; GLUTAMIC ACID; IONOTROPIC RECEPTOR; LINSIDOMINE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; QUINOLINIC ACID; TRITIUM; 3 MORPHOLINO SYDNONIMINE; 3-MORPHOLINO-SYDNONIMINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID RECEPTOR STIMULATING AGENT; DIAGNOSTIC AGENT; DRUG DERIVATIVE; KAINIC ACID; MOLSIDOMINE; N METHYLASPARTIC ACID; NITRIC OXIDE DONOR; QUISQUALIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME INHIBITION; HIPPOCAMPUS; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; SYNAPTIC MEMBRANE; ANIMAL; BINDING COMPETITION; CELL MEMBRANE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; METABOLISM; NERVE DEGENERATION; PATHOLOGY; WISTAR RAT;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMAL; BINDING, COMPETITIVE; CELL MEMBRANE; EXCITATORY AMINO ACID AGONISTS; GLUTAMIC ACID; HIPPOCAMPUS; KAINIC ACID; MALE; MOLSIDOMINE; N-METHYLASPARTATE; NERVE DEGENERATION; NITRIC OXIDE DONORS; NITRIC-OXIDE SYNTHASE; NITROARGININE; QUINOLINIC ACID; QUISQUALIC ACID; RATS; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T; TRITIUM; ANIMALS; NITRIC OXIDE SYNTHASE;

EID: 0036025013     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Metabotropic glutamate receptors negatively coupled to adenylate cyclase inhibit N-methyl-D-aspartate receptor activity and prevent neurotoxicity in mesencephalic neurons in vitro
2. Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: Protection by melatonin and deprenyl
3. Energetic dysfunction in quinolinic acid lesioned rat striatum
4. Regulation of N-methyl-D-aspartate-induced toxicity in the neostriatum: A role for metabotropic glutamate receptors?
5. Pharmacology and functions of metabotropic glutamate receptors
6. Selectivity of amino acid transmitters acting at NMDA and AMPA receptors
7. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures
8. Nitric oxide synthase: Irreversible inhibition by L-N-nitroarginine in brain in vitro and in vivo
9. The use of nitric oxide donors in pharmacological studies
10. A dual role for nitric oxide in NMDA-mediated toxicity in vivo
11. Potentiation of quinolinate-induced hippocampal lesions by inhibition of NO synthesis
12. Intracerebroventricular administration of quinolinic acid induces a selective decrease of inositol(1,4,5)-triphosphate receptor in rat brain
13. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurologic disease
14. Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid
15. Human microglia convert L-tryptophan into the neurotoxin quinolinic acid
16. Effect of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
17. Dual actions of nitric oxide in N-methyl-D-aspartate receptor-mediated neurotoxicity in cultured retinal neurons
18. Modulation of quinolinic acid-induced depletion of striatal NADPH diaphorase and enkephalinergic neurons by inhibition of nitric oxide synthase
19. Quinolinate neurotoxicity and glutamatergic structures
20. Effects of MK-801, ketamine and alaptide on quinolinate models in the maturing hippocampus
21. Neuroprotective actions of novel and potent ligands of group I and II metabotropic glutamate receptors
22. Chronic NO synthase inhibition fails to protect hippocampal neurones against NMDA toxicity
23. Altered glutamate binding following quinolinate lesions in developing rat brain
24. Protein measurement with Folin phenol reagent
25. The metabotropic excitatory amino acid receptor agonist IS, 3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury
26. Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesions
27. Differential loss of neurochemical markers following quinolinic acid-induced lesions of rat striatum
28. 3H]glutamate in synaptic membranes from rat brain
29. Nitric oxide synthase inhibition prevents acute quinolinate-induced striatal neurotoxicity
30. Separation of quisqualate- and kainate-selective glutamate receptors in cultured neurons from the rat superior colliculus
31. Neurotoxicity of NAAG in vivo is sensitive to NMDA antagonists and mGluR II ligands
32. The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR 2 receptor subunits
33. Inhibition of rat brain glutamate receptors by philanthotoxin
34. 3H]glutamate binding sites in rat cerebellum
35. Effect of quinolinic acid on endogenous antioxidants in rat corpus striatum
36. Quinolinic acid induces oxidative stress in rat brain synaptosomes
37. Metabotropic glutamate receptors in brain function and pathology
38. Metabotropic glutamate receptors and neuronal degenerative disorders
39. 3H]glutamate receptor binding in membranes
40. Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice
41. Excitotoxic models of neurodegenerative disorders
42. 3H]MK-801 binding to rat brain synaptic membranes in the presence of glycine and spermidine
43. 3H]Glutamate binding sites in the rat pituitary
44. 3H]]glutamate receptor binding assays