Botulinum neurotoxin A blocks cholinergic ganglionic neurotransmission in the dog heart

Japanese Journal of Pharmacology

Volumn 89, Issue 3, 2002, Pages 249-254

  Tsuboi, Masato ^a   Furukawa, Yasuyuki ^a   Kurogouchi, Fumio ^a   Nakajima, Koichi ^a   Hirose, Masamichi ^a   Chiba, Shigetoshi ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Botulinum toxin; Bradycardia; Cholinergic neurotransmission; Intracardiac parasympathetic ganglia

Indexed keywords

BOTULINUM TOXIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATRIOVENTRICULAR CONDUCTION; BRADYCARDIA; CARDIOVASCULAR RESPONSE; CHOLINERGIC RECEPTOR BLOCKING; CHOLINERGIC TRANSMISSION; CHRONOTROPISM; CONTROLLED STUDY; DOG; DRUG EFFECT; DRUG RESPONSE; GANGLION BLOCK; HEART; HEART ATRIUM CONDUCTION; INJECTION; METABOLIC INHIBITION; NERVE CELL STIMULATION; NEUROTRANSMISSION; NONHUMAN; PARASYMPATHETIC NERVE; PHARMACOLOGICAL BLOCKING; PREGANGLIONIC NERVE; SINUS NODE; VAGUS NERVE STIMULATION; ANIMAL; CHEMICAL PHENOMENA; CHOLINERGIC NERVE; HEART RATE; PARASYMPATHETIC GANGLION; PHYSIOLOGY; SYNAPTIC TRANSMISSION; VAGUS NERVE;

ANIMALS; BOTULINUM TOXIN TYPE A; CHOLINERGIC FIBERS; DEPRESSION, CHEMICAL; DOGS; GANGLIA, PARASYMPATHETIC; HEART; HEART RATE; SINOATRIAL NODE; SYNAPTIC TRANSMISSION; VAGUS NERVE;

EID: 0036023888     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.89.249     Document Type: Article

References (20)

1. Tetanus and botulinum neurotoxins are zinc proteases specific for components of the neuroexocytosis apparatus
2. Mechanism of action of tetanus and botulinum neurotoxins
3. Therapeutic uses of botulinum toxin
4. Botulinum neurotoxins: Mechanism of action and therapeutic applications
5. Botulinum toxin for chronic anal fissure
6. Prospective study of esophageal botulinum toxin injection in high-risk achalasia patients
7. Relief by botulinum toxin of voiding dysfunction due to prostatitis
8. Cardiac effects of botulinal toxin
9. Selective stimulation of parasympathetic nerve fibers to the human sino atrial node
10. Selective parasympathectomy of automatic and conductile tissues of the canine heart
11. Selective vagal innervation of sinoatrial and atrioventricular nodes in canine heart
12. Cardiac electrical responses to vagal stimulation of fibers to discrete cardiac regions
13. Functional distribution of the peripheral cardiac sympathetic pathways
14. Ganglioside GT1b as a complementary receptor component for Clostridium botulinum neurotoxins
15. Selective ganglionic blockade of vagal inputs to sinoatrial and/or atrioventricular regions
16. Differential intracardiac sympathetic and parasympathetic innervation to the SA and AV nodes in anesthetized dog hearts
17. Gross and microscopic anatomy of the canine intrinsic cardiac nervous system
18. Effects of botulinum toxin on autonomic nerves in a dually innervated tissue
19. Botulinum A toxins: Units versus units
20. Endoscopic injection of botulinum toxin for biliary sphincter of Oddi dysfunction