Investigation of environmental factors for diagnosing malignant potential in oral epithelial dysplasia

Oral Oncology

Volumn 38, Issue 6, 2002, Pages 562-573

  Okazaki, Y ^a   Tanaka, Y ^a   Tonogi, M ^a   Yamane, G ^a  

^a TOKYO DENTAL COLLEGE   (Japan)

Author keywords

4 Nitroquinoline 1 oxide; Bcl 2; Diagnosis; Early cancer; Oral epithelial dysplasia; p53 Mutation

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; PROTEIN BCL 2; PROTEIN P53; CARCINOGEN; TUMOR MARKER; TUMOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CLASSIFICATION; CANCER DIAGNOSIS; CANCER STAGING; CARCINOGENESIS; CELL COUNT; CELL STRUCTURE; CONTROLLED STUDY; DISEASE SEVERITY; DYSPLASIA; EARLY DIAGNOSIS; ENVIRONMENTAL FACTOR; GENE MUTATION; IMMUNOHISTOCHEMISTRY; MALE; MOUTH CANCER; MOUTH MUCOSA; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WORLD HEALTH ORGANIZATION; ANIMAL; CHEMICALLY INDUCED DISORDER; DISEASE COURSE; ENZYME IMMUNOASSAY; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PRECANCER; SPRAGUE DAWLEY RAT; TONGUE TUMOR; TUMOR SUPPRESSOR GENE;

4-NITROQUINOLINE-1-OXIDE; ANIMAL; APOPTOSIS; BASE SEQUENCE; CARCINOGENS; DISEASE PROGRESSION; GENES, P53; IMMUNOENZYME TECHNIQUES; IN SITU NICK-END LABELING; MALE; MUTATION; NEOPLASM PROTEINS; PRECANCEROUS CONDITIONS; PROTEIN P53; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; TONGUE NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; ANIMALS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036023865     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1368-8375(01)00119-1     Document Type: Article

References (43)

1. Oral leukoplakia and malignant transformation. A follow-up study of 257 patients
2. The p53 tumour suppressor gene
3. Altered p53 in microdissected, metachronous, premalignant oral lesions from the same patients
4. P53 expression and p53 gene mutation in oral cancer and dysplasia
5. P53 gene mutations in sequential oral epithelial dysplasias and squamous cell carcinomas [see comments]
6. Sequential p53 mutation analysis of pre-invasive and invasive head and neck squamous carcinoma
7. Human papilloma viruses and p53 mutations in normal pre-malignant and malignant oral epithelia
8. P53 gene alterations and p53 protein in oral epithelial dysplasia and squamous cell carcinoma
9. A high prevalence of p53 mutations in pre-malignant oral erythroplakia
10. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis
11. Bcl-2 blocks p53-dependent apoptosis
12. In situ labeling of nucler DNA fragmentation in normal oral epithelia and squamous cell carcinoma
13. Experimental tongue carcinoma of rats induced by oral administration of 4-nitroquinoline 1-oxide (4NQO) in drinking water
14. Cell proliferation in the carcinogenic process of tongue carcinoma in rats induced by 4-nitroquinoline-1-oxide. 2
15. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
16. A microdissection technique for archival DNA analysis of specific cell populations in lesions 1 mm in size
17. P53 mutations in human cancers
18. Structure of the rat p53 tumor suppressor gene
19. Subjectivity in evaluating oral epithelial dysplasia, carcinoma in situ and initial carcinoma
20. Oral epithelial dysplasia and the development of invasive squamous cell carcinoma
21. Oral leukoplakia, with emphasis on malignant transformation. A follow- up study of 46 patients
22. Morphometric investigation of the epithelial dysplasia of the gingiva
23. Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes
24. P53 expression in squamous dysplasia associated with carcinoma of the oesophagus: Evidence for field carcinogenesis [In Process Citation]
25. Mutations in the p53 gene: An early marker of neoplastic progression in ulcerative colitis
26. Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis
27. Overexpression of p53 is an early event in the tumorigenesis of oral squamous cell carcinomas
28. P53 protein expression in sequential biopsies of oral dysplasias and in situ carcinomas
29. P53 expression in various stages of 4-nitroquinoline 1-oxide induced carcinoma in the rat tongue
30. Expression of programmed cell death regulatory p53 and bcl-2 proteins in oral lesions
31. Apoptosis-associated proteins and the development of oral squamous cell carcinoma
32. Changes in Bcl-2 and bax expression in rat tounge during 4NQO induced carcinogenesis
33. Differential expression of bcl-2 and bax in squamous cell carcinomas of the oral cavity
34. Apoptosis, mitosis, PCNA and bcl-2 in normal, leukoplakic and malignant epithelia of the human oral cavity: Prospective, in vivo study
35. Oral squamous cell carcinoma is associated with decreased bcl-2/bax expression ratio and increased apoptosis
36. Apoptosis in normal epithelium, premalignant and malignant lesions of the oropharynx and oral cavity: A preliminary study
37. Evidence of repair of DNA damage induced by 4-hydroxyaminoquinoline 1-oxide in guinea pig pancreatic slices in vitro
38. The incidence of p53 mutations increases with progression of head and neck cancer
39. Experimental oral carcinoma of the tongue and buccal mucosa: Possible biologic markers linked to cancers at two anatomic sites
40. Infrequent Ha-ras mutations and absence of Ki-ras, N-ras, and p53 mutations in 4-nitroquinoline 1-oxide- induced rat oral lesions
41. Detection of p53 gene mutations in leukoplakia and well differentiated squamous cell carcinoma by polymerase chain reaction- single strand conformation polymorphism analysis
42. Non-radioactive screening of p53 mutations in human oral cancers detected by single strand conformation polymorphism analysis. Comparison with the protein accumulation