Prevention of experimental carotid and coronary artery thrombosis by the glycoprotein IIb/IIIa receptor antagonist CRL42796

British Journal of Pharmacology

Volumn 136, Issue 6, 2002, Pages 927-937

  Hennan, James K ^a   Hong, Ting Ting ^a   Willens, David E ^a   Driscoll, Edward M ^a   Giboulot, Thierry A ^a   Lucchesi, Benedict R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Arachidonic acid; Arterial stenosis; Arterial thrombosis; Aspirin; Bleeding time; CRL47926; GPIIb IIIa receptor antagonist; Platelet aggregation; Vessel wall injury

Indexed keywords

2 [(2 NAPHTHYLSULFONYL)AMINO] 3 [[2 [[4 (4 PIPERIDINYL) 2 [2 (4 PIPERIDINYL)ETHYL]BUTANOYL]AMINO]ACETYL]AMINO]PROPANOIC ACID; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ARACHIDONIC ACID; CITRIC ACID; CRL 42796; FIBRINOGEN RECEPTOR ANTAGONIST; HEPARIN; UNCLASSIFIED DRUG; ANTITHROMBOCYTIC AGENT; DIPEPTIDE; FIBRINOGEN RECEPTOR; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTERY OCCLUSION; ARTICLE; CAROTID ARTERY THROMBOSIS; CONTROLLED STUDY; CORONARY ARTERY THROMBOSIS; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG INFUSION; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOCYTE RICH PLASMA; ANIMAL; BLEEDING TIME; DOG; DRUG ANTAGONISM; INTRAARTERIAL DRUG ADMINISTRATION; STENOSIS, OCCLUSION AND OBSTRUCTION;

ANIMAL; ASPIRIN; BLEEDING TIME; CAROTID ARTERY THROMBOSIS; CONSTRICTION, PATHOLOGIC; CORONARY THROMBOSIS; DIPEPTIDES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; INFUSIONS, INTRA-ARTERIAL; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; SULFONAMIDES; SUPPORT, NON-U.S. GOV'T; ANIMALS;

EID: 0036022640     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704744     Document Type: Article

References (22)

1. Sustained inhibition of vessel wall-platelet interaction after deep coronary artery injury by temporary inhibition of the platelet glycoprotein IIb/IIIa receptor
2. In vivo models of arterial thrombosis and thrombolysis
3. A critical reappraisal of the bleeding time
4. Advances in antithrombotic therapy of acute myocardial infarction
5. Primary angioplasty compared with thrombolysis: New issues in the era of glycoprotein IIb/IIIa inhibition and intracoronary stenting
6. Effects of selective cyclooxygenase-2 inhibition on vascular responses and thrombosis in canine coronary arteries
7. Temporary and partial inhibition of platelets by SM-20302 prevents coronary artery thrombosis in a chronic canine model
8. Isolation and characterization of a chymotryptic fragment of platelet glycoprotein IIb/IIIa retaining Arg-Gly-Asp binding activity
9. Prevention of thrombosis and rethrombosis and enhancement of the thrombotic actions of recombinant tissue-type plasminogen activator in the canine heart by DMP728, a glycoprotein IIb/IIIa antagonist
10. Effects of GPIIb/IIIa receptor monoclonal antibody (7E3), heparin, and aspirin in an ex vivo canine arteriovenous shunt model of stent thrombosis
11. Cellular interactions of platelets in thrombosis
12. Antiplatelet antibody [7E3 F(ab′)2] prevents rethrombosis after recombinant tissue-type plasminogen activator-induced coronary artery thrombolysis in a canine model
13. Effect of calcium on GPIIb/IIIa interactions with integrilin: Enhanced GPIIb/IIIa binding and inhibition of platelet aggregation by reductions in the concentration of ionized calcium in plasma anticoagulated with citrate
14. The in vivo efficacy of SM-20302, a GPIIb/IIIa receptor antagonist, correlates with ex vivo platelet inhibition in heparinized blood but not in citrated blood
15. Electrical induction of coronary artery thrombosis in the ambulatory canine: A model for in vivo evaluation of antithrombotic agents
16. Antithrombotic effects of DMP-728, a platelet GPIIb/IIIa receptor antagonist, in a canine model of arterial thrombosis
17. Prevention of rethrombosis after coronary thrombolysis in a chronic canine model: I. Adjunctive therapy with monoclonal antibody 7E3 F(ab′)2 fragment
18. Chimeric 7E3 prevents carotid artery thrombosis in cynomolgus monkeys
19. Platelet GPIIb/IIIa receptor inhibition by SC-49992 prevents thrombosis and rethrombosis in the canine carotid artery
20. New recommendations from the 1999 American College of Cardiology/American Heart Association acute myocardial infarction guidelines
21. Calcium-dependent binding of a synthetic Arg-Gly-Asp (RGD) peptide to a single site on the purified platelet glycoprotein IIb/IIIa complex
22. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs