Subchronic toxicity of chloral hydrate on rats: A drinking water study

Journal of Applied Toxicology

Volumn 22, Issue 4, 2002, Pages 227-236

  Poon, R ^a,c   Nakai, J ^a   Yagminas, A ^a   Benoit, F ^a   Moir, D ^a   Chu, I ^a   Valli, V E ^b  

^a HEALTH CANADA   (Canada)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c Environmental Health Centre Ottawa   (Canada)

Author keywords

Chloral hydrate; Disinfection byproducts; Enzyme effects; Subchronic toxicity; Trichloroacetic acid

Indexed keywords

ALDEHYDE DEHYDROGENASE; BIOGENIC AMINE; CATALASE; CHLORAL HYDRATE; DISINFECTANT AGENT; DRINKING WATER; LIVER ENZYME; TRICHLOROACETIC ACID; TRICHLOROETHANOL; UNSPECIFIC MONOOXYGENASE; ENZYME INHIBITOR;

ARTICLE; AUTOPSY; BIOCHEMISTRY; BLOOD CHEMISTRY; BODY WEIGHT; CELL VACUOLE; CHEMICAL ANALYSIS; CHRONIC TOXICITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FLUID INTAKE; FOOD INTAKE; HEMATOLOGY; HISTOLOGY; IC 50; IN VITRO STUDY; LUNG FLUID; MALE; MYELIN SHEATH; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; URINALYSIS; WATER SUPPLY; WEIGHT GAIN; ANIMAL; BLOOD; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SURVEILLANCE PROGRAM; ENZYMOLOGY; LIVER; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; SPRAGUE DAWLEY RAT; WATER POLLUTANT;

ADMINISTRATION, ORAL; ALDEHYDE DEHYDROGENASE; ANILINE HYDROXYLASE; ANIMAL; CATALASE; CHLORAL HYDRATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; LIVER; MALE; MYELIN SHEATH; NO-OBSERVED-ADVERSE-EFFECT LEVEL; OPTIC NERVE; RATS; RATS, SPRAGUE-DAWLEY; TRICHLOROACETIC ACID; VACUOLES; WATER POLLUTANTS, CHEMICAL; WATER SUPPLY; ANIMALS;

ANIMALIA;

EID: 0036020568     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jat.843     Document Type: Article

References (56)

1. Monographs on the Evaluation of Carcinogenic Risks to Humans
2. Water disinfection: A review with some consideration of the requirement of the Third World
3. A National Survey of Chlorinated Disinfection By-Products in Canadian Drinking Water (95-EHD-197)
4. The occurrence of disinfection by-products in US drinking water
5. Disinfection by-products in Canadian drinking water
6. Toxicology of chloral hydrate in the mouse
7. Behavioral toxicity of chloral in mice: An approach to evaluation
8. Humoral and cell-mediated immune status in mice exposed to chloral hydrate
9. Ninety-day toxicity study of chloral hydrate in the Sprague-Dawley rat
10. Preliminary screening for the potential of drinking water disinfection byproducts to alter male reproduction
11. Biochemical effects of chloral hydrate on male rats following 7-day drinking water exposure
12. N-Acetylglucosaminidase activity in bronchoalveolar lavage fluid -characterization and response to ozone exposure
13. Subchronic toxicity of 3,3′,4,4′,5-pentachlorobiphenyl in the rat. 1. Clinical, biochemical, hematological, and histopathological changes
14. Modification of the Bodian technique applied to insect nerves
15. Species comparison of acute inhalation toxicity of ozone and phosgene
16. Assay for serum lipid peroxide level and its clinical significance
17. Modification of hepatic proteins in rats exposed to high oxygen concentration
18. Factors influencing the metabolism of drugs in liver microsomes
19. Ethoxy-, pentoxy-, and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochrome P-450
20. Measurement of cytochrome P-450 dependent dealkylation of alkoxyphenoxasones in hepatic S9 and hepatocyte homogenates: Effects of dicumarol
21. Glutathione S-transferase. The first enzymatic step in mercapturic acid formation
22. 4-Nitrophenol UDP-glucuronyl-transferase (rat liver)
23. A sensitive spectrophotometric assay for peroxisomal acyl-CoA oxidase
24. A modified catalase assay suitable for a plate reader and for the analysis of brain cell cultures
25. Trichloroethylene inhibits aldehyde dehydrogenase only for aliphatic aldehydes of short chains in rats
26. Effects of in utero and lactational exposure of the laboratory rat to 2,4,2′,4′- and 3,4,3′,4′-tetrachlorobiphenyl on dopamine function
27. Maps and Guide to Microdissection of the Rat Brain
28. Lightly chlorinated ortho-substituted PCB congeners decrease dopamine in nonhuman primate brain and tissue culture. 1990
29. Chemically induced myelinopathies
30. Agdehyde inhibitors of aldehyde dehydrogenases
31. Pharmacokinetic analysis of chloral hydrate and its metabolism in B6C3F1 mice
32. The extent of dichloroacetate formation from trichloroethylene, chloral hydrate, trichloroacetate, and trichloroethanol in B6C3F1 mice
33. Metabolism of chloral hydrate in mice and rats after single and multiple doses
34. Stimulation of catalase synthesis and increase of carnitine acetyltransferase activity in the liver of intact female rats fed clofibrate
35. Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid (ω-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone
36. Sex-dependent regulation of hepatic peroxisome proliferation in mice by trichloroethylene via peroxisorne proliferator-activated receptor α (PPARα)
37. Trichloroacetic acid effects on rat liver peroxisomal and enzyme-altered loci
38. Chlorinated hydrocarbon-induced peroxisomal enzyme activity in relation to species and organ carcinogenicity
39. Administration of subtoxic doses of t-butyl alcohol and trichloroacetic acid to male Wistar rats to study the interactive toxicity
40. Regulation of triglycericle metabolism by PPARs: Fibrate and thiazoliclinediones have distinct effects
41. Aldehyde dehydrogenase and their role in carcinogenesis
42. Acetaldehyde metabolism in vivo during ethanol intoxication
43. Degreasers' flush
44. The oxidation of acrolein by rat liver aldehyde dehydrogenases. Relation to allyl alcohol hepatotoxicity
45. Aldehyde dehydrogenase polymorphism: Molecular basis and phenotypic relationship to alcohol sensitivity
46. Aldehyde dehydrogenase polymorphism in North American, South American, and Mexican Indian populations
47. Metabolic and peroxisorne proliferation studies with di(2-ethylhexyl) phthalate in rats and monkeys
48. Comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, syrian hamster, guinea pig and marmoset
49. The peroxisome proliferator nafenopin does not suppress hepatocyte apoptosis in guinea pig liver in vivo nor in human hepatocytes in vitro
50. Peroxisome proliferators: Mechanism of adverse effects in rodents and molecular basis for species differences
51. Regulation of gene expression by fatty acids and fibric acid derivatives: An integrative role for PPARs
52. Mode of action of peroxisome proliferators as hypolipidemic drugs
53. Is peroxisome proliferation an obligotory precursor step i n the Carcinogenicity of di(2-ethyhexyl)phthalate (DZHP)?