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Volumn 16, Issue 1-2, 2002, Pages 45-51
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Evaluation of the role of intestinal and liver metabolism in the conversion of two different ester prodrugs of sanfetrinem to the parent drug in vitro and in vivo using different rat tissues and a surgically prepared rat model
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Author keywords
Ester prodrug; In vitro esterase stability; In vivo porta cava rat model; Sanfetrinem
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Indexed keywords
ABSORPTION;
ANTIBIOTICS;
BLOOD;
ESTERS;
METABOLISM;
PH EFFECTS;
SURGERY;
TISSUE;
SYSTEMIC CIRCULATION;
DRUG PRODUCTS;
ANTIBIOTIC AGENT;
BETA LACTAMASE;
BUFFER;
ESTER;
GW 549771X;
PRODRUG;
SANFETRINEM;
SANFETRINEM CILEXETIL;
UNCLASSIFIED DRUG;
ANTIINFECTIVE AGENT;
LACTAM;
ANIMAL EXPERIMENT;
ANIMAL TISSUE;
ARTICLE;
CALCULATION;
CONCENTRATION (PARAMETERS);
CONTROLLED STUDY;
DRUG ABSORPTION;
DRUG BLOOD LEVEL;
DRUG DETERMINATION;
DRUG METABOLISM;
HYDROLYSIS;
IN VITRO STUDY;
IN VIVO STUDY;
INTESTINE;
INTESTINE EPITHELIUM;
INTESTINE WALL;
JEJUNUM;
LIVER METABOLISM;
LIVER MICROSOME;
NONHUMAN;
PH;
PORTAL VEIN;
PRIORITY JOURNAL;
RAT;
SURGICAL TECHNIQUE;
SYSTEMIC CIRCULATION;
VENOUS BLOOD;
ANIMAL;
ANIMAL MODEL;
ANTIBODY SPECIFICITY;
BIOAVAILABILITY;
CAVA VEIN;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
INTESTINE MUCOSA;
LIVER;
MALE;
METABOLISM;
ORAL DRUG ADMINISTRATION;
WISTAR RAT;
ADMINISTRATION, ORAL;
ANIMAL;
ANTIBIOTICS, LACTAM;
BIOLOGICAL AVAILABILITY;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
ESTERS;
IN VITRO;
INTESTINAL MUCOSA;
INTESTINES;
JEJUNUM;
LIVER;
MALE;
MODELS, ANIMAL;
ORGAN SPECIFICITY;
PORTAL VEIN;
PRODRUGS;
RATS;
RATS, WISTAR;
VENAE CAVAE;
ANIMALS;
ANTI-BACTERIAL AGENTS;
LACTAMS;
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EID: 0036020067
PISSN: 09280987
EISSN: None
Source Type: Journal
DOI: 10.1016/S0928-0987(02)00056-8 Document Type: Article |
Times cited : (6)
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References (7)
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