Synthesis and characterization of a novel glycopolymer with protective activity toward human anti-α-Gal antibodies

Glycobiology

Volumn 12, Issue 4, 2002, Pages 283-290

  Vetere, Amedeo ^a   Donati, Ivan ^a   Campa, Cristiana ^a   Semeraro, Sabrina ^a   Gamini, Amelia ^a   Paoletti, Sergio ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Glycopolymer; Linear B disaccharide; Transglycosylation; Xenotransplantation

Indexed keywords

1 (3 DIMETHYLAMINOPROPYL) 3 ETHYLCARBODIIMIDE; 4 AMINOPHENOL; 4 NITROPHENOL; 4 NITROPHENYLGALACTOSIDE; ALPHA GALACTOSIDASE; AMIDE; ANTIBODY; BUFFER; CARBOHYDRATE ANTIGEN; DISACCHARIDE; FUNCTIONAL GROUP; GALACTOSE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; OLIGOSACCHARIDE; ORGANIC SOLVENT; POLYMER; STYRENE MALEIC ANHYDRIDE COPOLYMER; SUCCINIMIDE DERIVATIVE; BIOPOLYMER;

ANIMAL CELL; ANTIGEN ANTIBODY REACTION; ANTIGEN SPECIFICITY; AQUEOUS SOLUTION; ARTICLE; BIOCOMPATIBILITY; CARBOHYDRATE SYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL BINDING; CONTROLLED STUDY; CYTOTOXICITY; GLYCOSYLATION; HUMAN; INFRARED SPECTROMETRY; MASS SPECTROMETRY; NONHUMAN; POLYMER PRODUCTION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION; ANIMAL; CARBOHYDRATE ANALYSIS; CELL LINE; ELECTROSPRAY MASS SPECTROMETRY; IMMUNOLOGY; NUCLEAR MAGNETIC RESONANCE; SWINE;

ANIMALIA; PHASEOLUS (ANGIOSPERM); SUS SCROFA;

ANIMALS; ANTIBODIES; BIOPOLYMERS; CARBOHYDRATE SEQUENCE; CELL LINE; GALACTOSE; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SWINE;

EID: 0036019908     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/12.4.283     Document Type: Article

References (39)

1. Xenograft rejection: Molecular mechanisms and therapeutic prospects
2. Strategies in oligosaccharide synthesis
3. Highly efficient chemoenzymatic synthesis of α-galactosyl epitopes with a recombinant α(1-3)-galactosyl-transferase
4. p-Nitrophenyl group for anomeric protection of oligosaccharides, selective oxidative cleavage via p-acetamidophenyl glycosides
5. A unique natural human IgG antibody with anti-α-galactosyl specificity
6. Human natural anti-α-galactosyl IgG: The specific recognition of α(1-3)-linked galactose residues
7. The natural anti-Gal IgG. III. The subtlely of immune tolerance in man as demonstrated by crossreactivity between natural anti-Gal and anti-B antibodies
8. Total synthesis of the natural antigen involved in the hyperacute rejection response to xenotransplantations
9. Identification of carbohydrate structures that bind human antiporcine antibodies: Implications for discordant xenografting in humans
10. Synthesis of blood-group substances. Part 11. Synthesis of the trisaccharide O-α-D-galactopyranosyl-
11. Xenotranplantation
12. Xenotranplantation
13. Free radical copolymerization of styrene and maleic acid anhydride
14. Total synthesis of globotriaosyl-E and Z-ceramides and isoglobotriaosyl-E-ceramide
15. Biochemistry of carbohydrate-protein interaction
16. Controlling yield and regioselectivity in the enzymatic synthesis of β-D-galactopyranosyl-β-D-xylopyranosides
17. Conjugation of poly(styrene-co-maleic acid) derivatives to the antitumor protein neocarzinostatin: Pronouced improvements inpharmacological properties
18. Chemoenzymatic synthesis of Galα1-3Gal, Galα1-3Galβ1-4GlcNAc, and their PEG-conjugates
19. Synthesis of branched poly-N-acetyl-lactosamine type pentaantennary pentacosasaccharide: Glycan part of a glycosyl ceramide from rabbit erythrocyte membrane
20. Stabilization of substances in circulation
21. Experimental chemical shift correlation maps from heteronuclear two-dimensional NMR spectroscopy. 1. Carbon-13 and proton chemical shifts of raffinose and its subunits
22. Bioconjugation of laminin peptide YIGSR with poly(styrene co-maleic acid) increases its antimetastatic effect on lung metastasis of B16-BL6 melanoma cells
23. α-Galactosyl oligosaccharides conjugated with polyethylene glycol as potential inhibitors of hyperacute rejection upon xenotransplantation
24. A simple strategy for changing the regioselectivity of glycosidase-catalyzed formation of disaccharide
25. Enzymatic synthesis of oligosaccharides
26. A simple strategy for changing the regioselectivity of glycosidase-catalyzed formation of disaccharide. II. Enzymatic synthesis in situ of various acceptor glycosides
27. α-D-Galactosidase-catalyzed synthesis of partially protected α-linked digalactopyranosides
28. Specificity of xenoreactive anti-Galα1-3Gal IgM for α-galactosyl ligands
29. Synthesis of α-D-galactopyranosyl-linked oligosaccharides containing the α-Gal-β-Gal-GlcNAc sequence employing methyl-2, 3, 4, 6-tetra-O-(4-methoxybenzyl)-1-thio-β-D-galactopyranoside as an efficient glycosyl donor
30. The α-galactosyl epitope: A sugar coating that makes viruses and cells unpalatable
31. Solid-phase synthesis of dendritic sialoside inhibitors of influenza A virus haemagglutinin
32. Anti-pig IgM antibodies in human serum react predominantly with Galα(1, 3)Gal epitopes
33. Polyacrylamides bearing pendant alpha-sialoside groups strongly inhibit agglutination of erythrocytes by Influenza virus-the strong inhibition reflects enhanced binding through cooperative polyvalent interactions
34. Blood group isoantibody stimulation in man by feeding blood group-active bacteria
35. Xenotranplantation
36. High-yield synthesis of N-acetyllactosamine by regioselective transglycosylation
37. All-transglycolytic synthesis and characterization of sialyl(α2-3)galactosyl(β1-4)xylosyl-p-nitrophenyl(β1-, an oligosaccharide derivative related to glycosaminoglycan biosynthesis
38. On the effect of the aglycon structure of three aryl β-D-galactosides on the yield and the regioselectivity of the transglycolytic synthesis of N-acetyllactosamine
39. Enhanced inhibition of human anti-Gal antibody binding to mammalian cells by synthetic α-Gal epitopes polymers