Valproate acidifies hippocampal CA3-neurons-a novel mode of action

European Neuropsychopharmacology

Volumn 12, Issue 4, 2002, Pages 279-285

  Bonnet, Udo ^a   Bingmann, Dieter ^a   Leniger, Tobias ^b   Scherbaum, Norbert ^a   Widman, Guido ^b   Hufnagel, Andreas ^b   Wiemann, Martin ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Bipolar affective disorders; Epilepsy; Intracellular pH; Valproate

Indexed keywords

2',7 BIS(2 CARBOXYETHYL) 5(6) CARBOXYFLUORESCEIN ACETOXYMETHYL ESTER; 4 AMINOBUTYRIC ACID A RECEPTOR; FLUORESCEIN DERIVATIVE; PICROTOXIN; POSTSYNAPTIC RECEPTOR; UNCLASSIFIED DRUG; VALPROIC ACID; ANTICONVULSIVE AGENT;

ACIDIFICATION; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; BRAIN NERVE CELL; BRAIN SLICE; CELL PH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; GABAERGIC TRANSMISSION; GUINEA PIG; HIPPOCAMPUS; HYPOTHESIS; MEMBRANE DEPOLARIZATION; MOOD; NERVE CELL MEMBRANE POTENTIAL; NERVE EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; ANIMAL; ARTICLE; BIOLOGICAL MODEL; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; IN VITRO STUDY; METABOLISM; NERVE CELL; PH; PHYSIOLOGY;

ANIMALS; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HIPPOCAMPUS; HYDROGEN-ION CONCENTRATION; MODELS, BIOLOGICAL; NEURONS; RECEPTORS, GABA-A; VALPROIC ACID;

EID: 0036019852     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(02)00023-8     Document Type: Article

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