Treatment with flutamide decreases cortisol clearance: Implications for therapy in congenital adrenal hyperplasia

Journal of Pediatric Endocrinology and Metabolism

Volumn 15, Issue 4, 2002, Pages 435-439

  Charmandari, Evangelia ^a   Johnston, A ^a   Honour, J W ^a   Brook, C G D ^a   Hindmarsh, P C ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Congenital adrenal hyperplasia; Cortisol clearance; Cortisol half life; Flutamide

Indexed keywords

ALDOSTERONE; ANDROGEN; FLUDROCORTISONE; FLUTAMIDE; GLUCOCORTICOID; HYDROCORTISONE; MINERALOCORTICOID; ANTIANDROGEN; ANTIINFLAMMATORY AGENT; STEROID;

ADOLESCENT; ALDOSTERONE RELEASE; ANDROGEN RELEASE; ARTICLE; CASE REPORT; CONGENITAL ADRENAL HYPERPLASIA; DRUG CLEARANCE; DRUG HALF LIFE; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPERANDROGENISM; STEROID 21 MONOOXYGENASE DEFICIENCY; AREA UNDER THE CURVE; BLOOD; HALF LIFE TIME;

ADOLESCENT; ADRENAL HYPERPLASIA, CONGENITAL; ANDROGEN ANTAGONISTS; ANTI-INFLAMMATORY AGENTS; AREA UNDER CURVE; FEMALE; FLUTAMIDE; HALF-LIFE; HUMANS; HYDROCORTISONE; HYPERANDROGENISM; STEROIDS;

EID: 0036018838     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.2002.15.4.435     Document Type: Article

References (11)

1. Steroid disorders in children: Congenital adrenal hyperplasia and apparent mineralocorticoid excess
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3. The use of adrenalectomy as a treatment for congenital adrenal hyperplasia
4. Flutamide, testolactone, and reduced hydrocortisone dose maintain normal growth velocity and bone maturation despite elevated androgen levels in children with congenital adrenal hyperplasia
5. Steroid profiling
6. Clearance
7. Clearance and renal excretion
8. Half life
9. Volume of distribution
10. Effect of flutamide on cortisol metabolism
11. Further studies on the effect of flutamide on cortisol metabolism