Eumelanin is a major determinant for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) incorporation into hair of mice

Pharmacology and Toxicology

Volumn 90, Issue 6, 2002, Pages 333-337

  Hegstad, Solfrid ^a   Reistad, Ragnhild ^a   Haug, Line S ^a   Alexander, Jan ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; DRUG METABOLITE; EUMELANIN; MELANIN; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; 2 AMINO 1 METHYL 6 PHENYLIMIDAZO(4,5 B)PYRIDINE; 2-AMINO-1-METHYL-6-PHENYLIMIDAZO(4,5-B)PYRIDINE; IMIDAZOLE DERIVATIVE;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CALCULATION; CHEMICAL BINDING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG DETERMINATION; HAIR ANALYSIS; HAIR COLOR; LINEAR SYSTEM; MATHEMATICAL COMPUTING; NEWBORN; NONHUMAN; PIGMENTATION; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; HAIR; MALE; MASS FRAGMENTOGRAPHY; METABOLISM; MOUSE;

AGE FACTORS; ANIMAL; ANIMALS, NEWBORN; COMPARATIVE STUDY; HAIR; HAIR COLOR; IMIDAZOLES; MALE; MASS FRAGMENTOGRAPHY; MELANINS; MICE; MICE, INBRED C57BL; SUPPORT, NON-U.S. GOV'T; ANIMALS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY;

ANIMALIA;

EID: 0036018539     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0773.2002.900607.x     Document Type: Article

References (32)

1. Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in nonhuman primates
2. Binding of the food mutagen PhIP in pigmented tissues of mice
3. Drug testing by urine and hair analysis: Complementary features and scientific issues
4. Nicotine and cotinine accumulation in pigmented and unpigmented rat hair
5. The effect of hair color on the incorporation of methadone into hair in the rat
6. Heterocyclic aromatic amine formation in grilled bacon, beef and fish and in grill scrapings
7. Incorporation of codeine and metabolites into hair. Role of pigmentation
8. Distribution of codeine and morphine into rat hair after long-term daily dosing with codeine
9. Incorporation of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) into hair of mice
10. Determination of the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human hair by solid-phase extraction and gas chromatography-mass spectrometry
11. Microanalysis of eumelanin and pheomelanin in hair and melanomas by chemical degradation and liquid chromatography
12. Spectrophotometric assay of eumelanin in tissue samples
13. Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes
14. Analysis of foods for heterocyclic aromatic amine carcinogens by solid-phase extraction and high-performance liquid chromatography
15. Cancer risk of heterocyclic amines in cooked foods: An analysis and implications for research
16. Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef
17. Molecular dosimetry of the food-borne carcinogen MeIQx using adducts of serum albumin
18. Effect of diet on serum albumin and hemoglobin adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans
19. Detection and measurement of MeIQx in human urine after ingestion of a cooked meat meal
20. Hair analysis for drugs of abuse. X. Effect of physicochemical properties of drugs on the incorporation rates into hair
21. Chemical characterization of hair melanins in various coat-color mutants of mice
22. Biochemical approach on the conservation of drug molecules during hair fiber formation
23. In vitro formation and degradation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) protein adducts
24. Heterocyclic aromatic amines in human urine following a fried meat meal
25. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human hair as biomarker for dietary exposure
26. Effect of pigmentation on the drug deposition in hair of grey-haired subjects
27. Polar and non-polar heterocyclic amines in cooked fish and meat products and their corresponding pan residues
28. The incorporation of drugs into hair: Relationship of hair color and melanin concentration to phencyclidine incorporation
29. History, present and future, of heterocyclic amines, cooked food mutagens
30. Tissue distribution of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in two strains of male rats
31. Possible effect of pigment on the pharmacokinetics of ofloxacin and its excretion in hair
32. Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation