Chloride increases adrenergic receptor-mediated platelet and vascular responses

American Journal of Hypertension

Volumn 15, Issue 6, 2002, Pages 492-498

  Vaitkevicius, Henrikas ^a   Turner, Immanuel ^b   Spalding, Aaron ^b   Lockette, Warren ^a,b,c  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c Space and Naval Warfare Systems Center Pacific   (United States)

Author keywords

Anion exchanger; Blood vessels; Carbonic anhydrase; Epinephrine; Humans; Hypertension; Intracellular pH; Platelets; Stroke; Thiazides; Thrombosis

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ACETAZOLAMIDE; ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR; AMMONIUM CHLORIDE; BICARBONATE; CARBONATE DEHYDRATASE; CATECHOLAMINE; CHLORIDE ION; CLONIDINE; DIURETIC AGENT; GLUCONATE SODIUM; MERCURY CHLORIDE; THIAZIDE DIURETIC AGENT; THIOMERSAL; ALPHA ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BENZOTHIADIAZINE DERIVATIVE; BICARBONATE CHLORIDE ANTIPORTER;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BLOOD VESSEL REACTIVITY; CELL LEVEL; CELL PH; CHLORIDE TRANSPORT; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOLATED ARTERY; MALE; MICROFLUOROMETRY; NONHUMAN; NORMAL HUMAN; OPTICAL DENSITY; PRIORITY JOURNAL; RAT; THROMBOCYTE AGGREGATION; THROMBOCYTE RICH PLASMA; ANIMAL; DRUG EFFECT; MUSCLE CONTRACTION; PHYSIOLOGY; SPECTROFLUOROMETRY; SPRAGUE DAWLEY RAT; THROMBOCYTE; VASCULAR SMOOTH MUSCLE;

ADRENERGIC ALPHA-AGONISTS; ANIMAL; BLOOD PLATELETS; CARBONIC ANHYDRASES; CHLORIDE-BICARBONATE ANTIPORTERS; CLONIDINE; DIURETICS, THIAZIDE; EPINEPHRINE; HUMAN; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PLATELET AGGREGATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA; SPECTROMETRY, FLUORESCENCE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS; BENZOTHIADIAZINES; DIURETICS; HUMANS; SODIUM CHLORIDE SYMPORTER INHIBITORS;

EID: 0036015035     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-7061(02)02276-8     Document Type: Article

References (30)

1. Mechanism of epinephrine-induced platelet aggregation
2. Ion channels in vascular smooth muscle: Alterations in essential hypertension
3. The distribution of chloride ions in the smooth muscle cells of the guinea pig's taenia coli
4. Chloride channels: An emerging molecular picture
5. i in cultured smooth muscle cells
6. Effect of 8-Br-cGMP on cation fluxes in cultured vascular smooth muscle cells
7. A simplified micromethod for the determination of carbonic anhydrase and its inhibitors
8. The determination of osteopetrotic phenotypes by selective inactivation of red cell carbonic anhydrase isoenzymes
9. Purification and properties of human erythrocyte carbonic anhydrase
10. Carbonic anhydrase in human platelets
11. Role of carbonic anbydrase in certain ionic exchanges involving the erythrocyte
12. Kinetics of carbonic anbydrase in whole red cells as measured by transfer of carbon dioxide and ammonia
13. Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family
14. 2 activates red blood cell K/Cl cotransport via stimulation of a phosphatase
15. Oxidative activation of K/Cl cotransport by diamide in erythrocytes from humans with red cell disorders
16. Effects of thiazides on colonic NaCl absorption: Role of carbonic anhydrase
17. Swelling-activated KCl cotransport in rabbit red cells: Flux is determined mainly by cell volume rather than shape
18. Osmosis and the regulation of cell volume
19. Evidence against a contribution by NaCl cotransport to chloride accumulation in rat arterial smooth muscle
20. Influence of Na+ on the A2AR system of human platelets
21. Major cardiovascular events in hypertensive patients randomized to doxazosin vs. chlorthalidone
22. Antihypertensive drug therapies and the risk of ischemic stroke
23. Identification and pharmacological properties of binding sites for the atypical thiazide diuretic, indapamide
24. Inhibition of carbonic anhydrase accounts for the direct vascular effects of hydrochlorothiazide
25. In vivo evidence for K(Ca) channel opening properties of acetazolamide in the human vasculature
26. Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action
27. Can cerebrovascular reactivity be assessed by dynamic susceptibility contrast-enhanced MRI?
28. Erythrocyte anion exchanger activity and intracellular pH in essential hypertension
29. "Salt-sensitive" essential hypertension in men. Is the sodium ion alone important?