Anti-CD11b monoclonal antibody suppresses brain dissemination of Cryptococcus neoformans in mice

Microbiology and Immunology

Volumn 46, Issue 3, 2002, Pages 181-186

  Kawakami, Kazuyoshi ^a   Koguchi, Yoshinobu ^a   Qureshi, Mahboob Hossain ^a,c   Zhang, Tiantuo ^a,b,d   Kinjo, Yuki ^a   Yara, Satomi ^a   Uezu, Kaori ^a   Shibuya, Kazutoshi ^b   Naoe, Shiro ^b   Saito, Atsushi ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF KENTUCKY   (United States)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

Brain; CD11b; Cryptococcus neoformans; Disseminated infection

Indexed keywords

BACTERIUM ANTIBODY; CD11B ANTIGEN; CD18 ANTIGEN; GLYCOPROTEIN P 15095; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCLONAL ANTIBODY; CELL ADHESION MOLECULE; MONOCLONAL ANTIBODY CD11B; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BRAIN; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; DBA MOUSE; DISEASE MODEL; FEMALE; IMMUNOLOGY; MICROBIOLOGY; MOUSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIGEN ANTIBODY REACTION; BRAIN DISEASE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FUNGAL DETECTION; LUNG; NONHUMAN; PATHOGENICITY; PROTEIN FAMILY;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; ANTIGENS, CD11A; ANTIGENS, CD11B; ANTIGENS, CD11C; ANTIGENS, CD18; BRAIN; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; DISEASE MODELS, ANIMAL; FEMALE; MICE; MICE, INBRED BALB C; MICE, INBRED DBA;

ANIMALIA; FILOBASIDIELLA NEOFORMANS;

EID: 0036009906     PISSN: 03855600     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2002.tb02684.x     Document Type: Article

References (21)

1. Structure and function of the leukocyte adhesion molecules CD11/CD18
2. Cytokine enhancement of complement-dependent phagocytosis by macrophages: Synergy of tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor for phagocytosis of Cryptococcus neoformans
3. Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neofonnans
4. Cryptococcal polysaccharides bind to CD18 on human neutrophils
5. Role of complement and complement receptor type 3 in phagocytosis of Lisleria monocytogenes by inflammatory mouse peritoneal macrophages
6. Interaction of the fungal pathogen Candida albicans with integrin CD11b/CD18: Recognition by the I domain is modulated by the lectin-like domain and the CD18 subunit
7. Activation of macrophages and expansion of specific T lymphocytes in the lungs of mice intratracheally inoculated with Cryptococcus neoformans
8. Contribution of interferon-γ in protecting mice during pulmonary and disseminated infection with Cryptococcus neoformans
9. Interleukin-12 protects mice against pulmonary and disseminated infection caused by Cryptococcus neoformans
10. Expression of cytokines and inducible nitric oxide synthase mRNA in the lungs of mice infected with Cryptococcus neoformans: Effects of interleukin-12
11. IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-γ production
12. Differential effect of Cryptococcus neoformans on the production of IL-12p40 and IL-10 by murine macrophages stimulated with lipopolysaccharide and gamma interferon
13. IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-γ production by NK cells
14. Localization on encapsulated Cryptococcus neoformans of serum components opsonic for phagocytosis by macrophages and neutrophils
15. Activation of the complement system by Cryptococcus neoformans leads to binding of iC3b to the yeast
16. Activation and binding of opsonic fragments of C3 on encapsulated Cryptococcus neoformans by using an alternative complement pathway reconstituted from six isolated proteins
17. Binding of Cryptococcus neoformans to heterologously expressed human complement receptors
18. Binding of Cryptococcus neoformans by human cultured macrophages. Requirements for multiple complement receptors and actin
19. Transfer of immunity to cryptococcosis by T-enriched splenic lymphocytes from Cryptococcus neoformans sensitized mice
20. Regulation of interleukin-12 by complement receptor 3 signalling
21. The WI-1 antigen of Blastomyces dermatitidis yeasts mediates binding to human macrophage CD11b/CD18 (CR3) and CD14