Paroxysmal nocturnal hemoglobinuriaDifferential gene expression of EGR-1 and TAXREB107

Experimental Hematology

Volumn 30, Issue 1, 2002, Pages 18-25

  Lyakisheva, Anna ^a   Felda, Olga ^a   Ganser, Arnold ^a   Schmidt, Reinhold E ^a   Schubert, Jörg ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CHLORAMBUCIL; CYCLOSPORIN; HYDROXYUREA; MEMBRANE PROTEIN; STEROID; DNA BINDING PROTEIN; EARLY GROWTH RESPONSE FACTOR 1; EGR1 PROTEIN, HUMAN; EGR1 PROTEIN, MOUSE; IMMEDIATE EARLY PROTEIN; TAX PROTEIN; TAX RESPONSIVE ELEMENT BINDING PROTEIN 107, MOUSE; TAX-RESPONSIVE-ELEMENT-BINDING PROTEIN 107, MOUSE; TRANSCRIPTION FACTOR;

ADULT; APLASTIC ANEMIA; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; DNA FINGERPRINTING; FEMALE; GENE EXPRESSION; GENE MUTATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; MALE; MYELODYSPLASTIC SYNDROME; NORTHERN BLOTTING; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA FINGERPRINTING; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; MIDDLE AGED;

ADULT; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; GENE EXPRESSION REGULATION; GENE PRODUCTS, TAX; HEMOGLOBINURIA, PAROXYSMAL; HUMANS; IMMEDIATE-EARLY PROTEINS; MIDDLE AGED; TRANSCRIPTION FACTORS;

EID: 0036007065     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(01)00763-9     Document Type: Article

References (54)

1. Deficiency of glycosylphosphatidylinositol-linked membrane glycoproteins of leukocytes in paroxysmal nocturnal hemoglobinuria, description of a new diagnostic cytofluorometric assay
2. - murine lymphoma mutants
3. The molecular basis of paroxysmal nocturnal hemoglobinuria
4. Paroxysmal nocturnal hemoglobinuria as a molecular disease
5. Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion
6. Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals
7. The dual pathogenesis of paroxysmal nocturnal hemoglobinuria
8. -, phosphatidylinositolglycan-anchor-deficient T lymphocytes after in vivo application of Campath-1H for refractory B-cell non-Hodgkin lymphoma
9. Preferential hematopoiesis by paroxysmal nocturnal hemoglobinuria clone engrafted in SCID mice
10. Is aplastic anaemia a pre-leukaemic disorder?
11. Development of the glycosylphosphatitylinositol-anchoring defect characteristic for paroxysmal nocturnal hemoglobinuria in patients with aplastic anemia
12. Detection of small populations of CD59-deficient erythrocytes in patients with aplastic anemia or myelodysplastic syndrome and normal individuals
13. Increased frequency of somatic mutations at glycophorin A loci in patients with aplastic anaemia, myelodysplastic syndrome and paroxysmal nocturnal haemoglobinuria
14. Genetic instability and the etiology of somatic PIG-A mutations in paroxysmal nocturnal hemoglobinuria
15. Arbitrarily primed PCR fingerprinting of RNA
16. A computer-driven approach to PCR-based differential screening, alternative to differential display
17. One-hour downward alkaline capillary transfer for blotting of DNA and RNA
18. Heterogeneous PIG-A mutations in different cell lineages in paroxysmal nocturnal hemoglobinuria
19. - hematopoietic precursors in paroxysmal nocturnal hemoglobinuria
20. Markedly high plasma erythropoietin and granulocyte colony-stimulating factor levels in patients with paroxysmal nocturnal hemoglobinuria
21. Research directions in paroxysmal nocturnal hemoglobinuria
22. Paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure syndromes
23. Mutations in the PIG-A gene causing paroxysmal nocturnal hemoglobinuria are mainly of the frameshift type
24. PNH cells are as sensitive to T-cell-mediated lysis as their normal counterparts; implications for the pathogenesis of paroxysmal nocturnal haemoglobinuria
25. The CD1 system; antigen-presenting molecules for T cell recognition of lipids and glycolipids
26. Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria
27. Mechanisms of bone marrow progenitor cell apoptosis in aplastic anaemia and the effect of anti-thymocyte globulin; examination of the role of the Fas-Fas-L interaction
28. Increased apoptosis of bone marrow cells and preserved proliferative capacity of selected progenitors predict for clinical response to anti-inflammatory therapy in myelodysplastic syndromes
29. Myelodysplasia
30. The PIG-A mutation and absence of glycosylphosphatidylinositol-linked proteins do not confer resistance to apoptosis in paroxysmal nocturnal hemoglobinuria
31. Glycosylphosphatidylinositol (GPI)-deficient Jurkat T cells as a model to study functions of GPI-anchored proteins
32. Granulocyte-macrophage colony-stimulating factor and tetradecanoyl phorbol acetate induce a distinct, restricted subset of primary-response TIS genes in both proliferating and terminally differentiated myeloid cells
33. Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals
34. A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1
35. The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor β-chain promoter through noncanonical Egr and Sp1 binding sites
36. The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage
37. The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells
38. cDna cloning of mRnas which increase rapidly in human lymphocytes cultured with concanavalin-a and cycloheximide
39. NGFI-A gene expression is necessary for T lymphocyte proliferation
40. Early growth response-1-dependent apoptosis is mediated by p53
41. Role of Egr-1 gene expression in B cell receptor-induced apoptosis in an immature B cell lymphoma
42. p53 and Egr-1 additively suppress transformed growth in Ht1080 cells but Egr-1 counteracts p53-dependent apoptosis
43. Physical interaction between p53 and primary response gene Egr-1
44. Decreased expression and activity of the immediate-early growth response (Egr-1) gene product during cellular senescence
45. Early growth response gene 1 stimulates development of hematopoietic progenitor cells along the macrophage lineage at the expense of the granulocyte and erythroid lineages
46. The zinc finger transcription factor Egr-1 activates macrophage differentiation in M1 myeloblastic leukemia cells
47. Cell cycling stress in the monocyte line as a risk factor for progression of the aplastic anaemia/paroxysmal nocturnal haemoglobinuria syndrome to myelodysplastic syndrome
48. Clinical features of the relationship between aplastic anemia and paroxysmal nocturnal hemoglobinuria
49. Paroxysmal nocturnal haemoglobinuria; a replacement of haematopoietic tissue?
50. Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells
51. Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in the human T-cell line, Jurkat
52. Identification of TAXREB107 as an erythropoietin early response gene
53. Paroxysmal nocturnal haemoglobinuria clones in patients with myelodysplastic syndromes