Low-density lipoprotein reconstituted by pyropheophorbide cholesteryl oleate as target-specific photosensitizer

Bioconjugate Chemistry

Volumn 13, Issue 3, 2002, Pages 392-396

  Zheng, Gang ^a   Li, Hui ^a   Zhang, Min ^a,b   Lund Katz, Sissel ^c   Chance, Britton ^a   Glickson, Jerry D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SHANGHAI UNIVERSITY   (China)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPROTEINS; TUMORS;

CHOLESTEROL OLEATE; LASER SCANNING CONFOCAL MICROSCOPY; LIPID CORES; LOW DENSITY LIPOPROTEIN RECEPTORS; LOW DENSITY LIPOPROTEINS; PHOTOSENSITISER; SYNTHESISED; TUMOUR CELLS;

PHOTOSENSITIZERS;

CHLOROPHYLL; CHOLESTEROL ESTER; CHOLESTEROL OLEATE; DRUG DERIVATIVE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PHOTOSENSITIZING AGENT; PYROPHEOPHORBIDE A;

ARTICLE; BINDING COMPETITION; CELL CULTURE; CHEMISTRY; CONFOCAL MICROSCOPY; DRUG EFFECT; ENDOSOME; FLUORESCENCE MICROSCOPY; HUMAN; LYSOSOME; METABOLISM;

BINDING, COMPETITIVE; CHLOROPHYLL; CHOLESTEROL ESTERS; ENDOSOMES; HUMANS; LIPOPROTEINS, LDL; LYSOSOMES; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; PHOTOSENSITIZING AGENTS; RECEPTORS, LDL; TUMOR CELLS, CULTURED;

EID: 0036000110     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc025516h     Document Type: Article

References (19)

1. Photodynamic therapy
2. Porphyrin-based photosensitizers for use in photodynamic therapy
3. Porphyrins as photosensitizers in photodynamic therapy
4. On the diffusion length of singlet oxygen in cells and tissues
5. Evolution of the LDL receptor concept - Cultured cells to intact animals
6. Preparation of drug-low-density lipoprotein complexes for delivery of antitumoral drugs via the low-density lipoprotein pathway
7. Low-density lipoprotein as a vehicle for targeting antitumor compounds to cancer cells
8. Delivery of lipophilic drugs using lipoproteins
9. In vitro interaction of the photoactive anticancer porphyrin derivative photofrin II with low-density lipoprotein, and its delivery to cultured human fibroblasts
10. Properties of incorporation, redistribution and integrity of porphyrin-low-density lipoprotein complexes
11. Role of delivery vehicles for photosensitizers in the photodynamic therapy of tumors
12. The effects of plasma-lipoproteins on in vitro tumor cell killing and in vivo tumor photosensitization with benzoporphyrin derivative
13. Replacement of neutral lipids of low-density lipoprotein with esters of long chain unsaturated fatty acids
14. Receptor-mediated uptake of low-density lipoprotein by B16 melanoma cells in vitro and in vivo in mice
15. Targeted killing of cultured cells by receptor-mediated photosensitization
16. Alkyl ether analogues of chlorophyll-a derivatives 0.1. Synthesis, photophysical properties and photodynamic efficacy
17. Protein measurement with the Folin phenol reagent
18. A quantitative structure-activity relationship for a congeneric series of pyropheophorbide derivatives as photosensitizers for photodynamic therapy
19. Low-density lipoproteins reconstituted with steroids containing the nitrobenzoxadiazole