Description and analysis of metabolic connectivity and dynamics in the human red blood cell

Biophysical Journal

Volumn 83, Issue 2, 2002, Pages 646-662

  Kauffman, Kenneth J ^a   Pajerowski, John David ^a,c   Jamshidi, Neema ^b   Palsson, Bernhard O ^b   Edwards, Jeremy S ^a  

^a University of Delaware   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c Physiome Sciences Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COMPUTER MODEL; CONCENTRATION (PARAMETERS); DECOMPOSITION; ERYTHROCYTE METABOLISM; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; STATISTICAL ANALYSIS; BIOLOGICAL MODEL; BIOPHYSICS; COMPUTER PROGRAM; COMPUTER SIMULATION; ERYTHROCYTE; METABOLISM; PHYSIOLOGY; STATISTICAL MODEL; TIME;

BIOPHYSICS; COMPUTER SIMULATION; ERYTHROCYTES; HUMANS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; SOFTWARE; TIME FACTORS;

EID: 0035996969     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(02)75198-9     Document Type: Article

References (43)

1. Statistical construction of chemical reaction mechanisms from measured time-series
2. A test case of correlation metric construction of a reaction pathway from measurements
3. Interaction of the Embden-Meyerhof pathway and hexose monophosphate shunt in erythrocytes
4. Mathematical modeling and analysis in biochemical engineering: Past accomplishments and future opportunities
5. A metabolic osmotic model of human erythrocytes
6. Multiple steady states in kinetic models of red cell metabolism
7. Metabolic regulation and mathematical models
8. Linear theory of enzymatic chains: Its application for the analysis of the crossover theorem and of the glycolysis of human erythrocytes
9. Mathematical analysis of multienzyme systems: II. Steady state and transient control
10. Mathematical modelling of metabolic pathways affected by an enzyme deficiency: A mathematical model of glycolysis in normal and pyruvate- kinase-deficient red blood cells
11. Mathematical modelling of metabolic pathways affected by an enzyme deficiency
12. The energy metabolism of pyruvate kinase deficient red blood cells
13. Mathematical model of pyruvate kinase of chicken erythrocytes
14. Hemolytic anemias due to erythrocyte enzyme deficiencies
15. Dynamic simulation of the human red blood cell metabolic network
16. Metabolic dynamics in the human red cell: Part I. A comprehensive kinetic model
17. Metabolic dynamics in the human red cell: Part II. Interactions with the environment
18. Metabolic dynamics in the human red cell: Part III. Metabolic reaction rates
19. Metabolic dynamics in the human red cell: Part IV. Data prediction and some model computations
20. A comprehensive model of human erythrocyte metabolism: Extensions to include pH effects
21. Volume, pH, and ion-content regulation in human red cells: Analysis of transient behavior with an integrated model
22. Comparison of computer simulations of the F-type and L-type nonoxidative hexose monophosphate shunts with 31P-NMR experimental data from human erythrocytes
23. Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: Computer simulation and metabolic control analysis
24. Making mathematical descriptions of metabolic reaction networks manageable
25. Reducing complexity in metabolic networks: Making metabolic meshes manageable
26. Mathematical modelling of dynamics and control in metabolic networks: Part I. On Michaelis-Menten kinetics
27. Kinetic analysis of the human erythrocyte glyoxalase system using 1H NMR and a computer model
28. The effect of pyruvate on glycolysis and the maintenance of adenine nucleotides in red cells
29. Mathematical analysis of multienzyme systems: I. Modelling of the glycolysis of human erythrocytes
30. The regulatory principles of glycolysis in erythrocytes in vivo and in vitro: A minimal comprehensive model describing steady states, quasi-steady states and time-dependent processes
31. Mathematical modelling of glycolysis and adenine nucleotide metabolism of human erythrocytes: I. Reaction-kinetic statements, analysis of in vivo state and determination of starting conditions for in vitro experiments
32. Interrelations between glycolysis and the hexose monophosphate shunt in erythrocytes as studied on the basis of a mathematical model
33. Mathematical modelling of energy and redox metabolism of G6PD-deficient erythrocytes
34. Mathematical modelling of metabolic pathways affected by an enzyme deficiency: Energy and redox metabolism of glucose-6-phosphate-dehydrogenase-deficient erythrocytes
35. Computer simulation of the metabolic consequences of the combined deficiency of 6-phosphogluconolactonase and glucose-6-phosphate dehydrogenase in human erythrocytes
36. A kinetic model for the interaction of energy metabolism and osmotic states of human erythrocytes: Analysis of the stationary "in vivo" state and of time dependent variations under blood preservation conditions
37. A thermodynamic model of hemoglobin suitable for physiological applications