Age-related decrease in the inducibility of heat-shock protein 70 in human peripheral blood mononuclear cells

Journal of Clinical Immunology

Volumn 22, Issue 4, 2002, Pages 195-205

  Njemini, R ^a   Abeele, M Vanden ^a   Demanet, C ^b   Lambert, M ^a   Vandebosch, S ^a   Mets, T ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

Aging; Heat shock; Heat shock protein 70; Peripheral mononuclear blood cells; Proinflammatory cytokines

Indexed keywords

CYTOKINE; HEAT SHOCK PROTEIN 70; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; INTERLEUKIN 1;

ADULT; AGED; AGING; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FLOW CYTOMETRY; HEAT SHOCK; HIGH TEMPERATURE PROCEDURES; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LYMPHOCYTE COUNT; MALE; MONONUCLEAR CELL; NORMAL HUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN INDUCTION; BLOOD; IMMUNOLOGY; LYMPHOCYTE; METABOLISM; MIDDLE AGED; MONOCYTE;

ADULT; AGED; AGED, 80 AND OVER; AGING; CYTOKINES; FEMALE; FLOW CYTOMETRY; HEAT-SHOCK PROTEINS 70; HUMAN; INFLAMMATION MEDIATORS; INTERLEUKIN-1; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTES; MALE; MIDDLE AGE; MONOCYTES; TUMOR NECROSIS FACTOR; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MIDDLE AGED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035996805     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016036724386     Document Type: Article

References (83)

1. The heat-shock proteins
2. Hormone 1 alpha, 25-dihydroxyvitamin D3 modulates heat shock response in monocytes
3. Structure and expression of the human gene encoding major heat shock protein HSP70
4. Heat-inducible human factor that binds to a human hsp70 promoter
5. Heat stress regulates the human 70-kDa heat-shock gene through the 3′-untranslated region
6. Acidosis alters hyperthermic cytotoxicity and the cellular stress response
7. Molecular chaperones and the aging process
8. Progress and perspectives on the biology of heat shock proteins and molecular chaperones
9. Effect of age and dietary restriction on expression of heat shock protein 70 in rat alveolar macrophages
10. The induction of gene activity in drosophilia by heat shock
11. Heat shock and the heat shock proteins
12. The heat-shock response
13. Speculations on the functions of the major heat shock and glucose-regulated proteins
14. Heat shock proteins: The search for functions
15. Structure and expression of a human gene coding for a 71 kd heat shock "cognate" protein
16. Drosophila gene related to the major heat shock-induced gene is transcribed at normal temperatures and not induced by heat shock
17. Proteins related to the mouse L-cell major heat shock protein are synthesized in the absence of heat shock gene expression
18. Constitutively expressed rat mRNA encoding a 70-kilodalton heat-shock-like protein
19. Cloning and expression of a gene encoding hsc73, the major hsp70-like protein in unstressed rat cells
20. Heat shock proteins protect cells from monocyte cytotoxicity: Possible mechanism of self protection
21. 70K heat shock related proteins stimulate protein translocation into microsomes
22. Heat shock proteins and the inflammatory response
23. Heat shock proteins: Facts, thoughts, and dreams
24. The molybdate-stabilized glucocorticoid binding complex of L-cells contains a 98-100 kdalton steroid binding phosphoprotein and a 90 kdalton non-steroid-binding phosphoprotein that is part of the murine heat-shock complex
25. Heat shock proteins functioning as molecular chaperones: Their roles in normal and stressed cells
26. Transient and developmental activation of heat shock genes
27. Heat shock is lethal to fibroblasts microinjected with antibodies against hsp70
28. Competitive inhibition of hsp70 gene expression causes thermosensitivity
29. Constitutive expression of heat-shock protein 70 in mammalian cells confers thermoresistance
30. Thermal response of rat fibroblasts stably transfected with the human 70-kDa heat shock protein-encoding gene
31. Expression of a heat-inducible gene of the HSP70 family in human myelomonocytic cells: Regulation by bacterial products and cytokines
32. Regulation and functions of stress proteins in allergy and inflammation
33. Anti-inflammatory effect of heat shock protein induction is related to stabilization of I kappa B alpha through preventing I kappa B kinase activation in respiratory epithelial cells
34. Heat shock protein suppresses the senescent lung cytokine response to acute endotoxemia
35. Role of hsp70 in cytokine production
36. Overexpression of major heat shock protein hsp70 inhibits tumor necrosis factor-induced activation of phospholipase A2
37. Hyperthermic modulation of respiratory inhibition factor- and iron releasing factor-dependent macrophage murine tumor cytotoxicity
38. Age-related attenuation in the expression of the major heat shock proteins in human peripheral lymphocytes
39. Stress-induced heat shock protein 70 expression in adrenal cortex: An adrenocorticotropic hormone-sensitive, age-dependent response
40. Nonenzymatic glycation of collagen in aging and diabetes
41. Protein oxidation in aging, disease, and oxidative stress
42. Synthesis, modifications, and turnover of proteins during aging
43. Carbonic anhydrase III. Oxidative modification in vivo and loss of phosphatase activity during aging
44. Age-related modifications in rat cardiac phosphoglycerate kinase. Rejuvenation of the old enzyme by unfolding-refolding
45. The Hsp70 and Hsp60 chaperone machines
46. 3
47. Heat-shock proteins, molecular chaperones, and the stress response: Evolutionary and ecological physiology
48. Hsp70 and aging
49. Concomitant decline in heat-induced hyperthermia and HSP70 mRNA expression in aged rats
50. The effect of age on the synthesis of two heat shock proteins in the hsp70 family
51. Attenuated induction of heat shock gene expression in aging diploid fibroblasts
52. Growth factors as probes of cell aging
53. Age-related attenuation of HSP47 heat response in fibroblasts
54. The expression of heat shock protein 70 decreases with cellular senescence in vitro and in cells derived from young and old human subjects
55. Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats
56. The expression of heat shock protein 70 decreases with age in lymphocytes from rats and rhesus monkeys
57. Diminished heat shock response in the aged myocardium
58. Age-dependent decrease in the heat-inducible DNA sequence-specific binding activity in human diploid fibroblasts
59. Stress response of senescent T lymphocytes: Reduced hsp70 is independent of the proliferative block
60. Attenuated expression of 70-kDa heat shock protein in WI-38 human fibroblasts during aging in vitro
61. Flow cytometry is a rapid and reliable method for evaluating heat shock protein 70 expression in human monocytes
62. Vascular heat shock protein expression in response to stress. Endocrine and autonomic regulation of this age-dependent response
63. HSP expression in human leukocytes is modulated by endurance exercise
64. Age-related decrease in the inductability of heat shock protein 72 in normal human skin
65. Expression of heat shock protein 70 decreases with age in hepatocytes and splenocytes from female rats
66. Increase in basal level of Hsp70, consisting chiefly of constitutively expressed Hsp70 (Hsc70) in aged rat brain
67. Immunolocalization of low-molecular-weight stress protein HSP 27 in normal skin and common cutaneous lesions
68. Alterations in the chaperone activity of hsp70 in aging organisms
69. The effect of adherence on the in vitro induction of cytocidal activity by macrophages
70. Monocyte adherence results in selective induction of novel genes sharing homology with mediators of inflammation and tissue repair
71. Erythrophagocytosis induces heat shock protein synthesis by human monocytes-macrophages
72. Endotoxin tolerance in rats: Expression of TNF-alpha, IL-6, IL-10, VCAM- 1 AND HSP 70 in lung and liver during endotoxin shock
73. Interleukin-1 beta depletes insulin messenger ribonucleic acid and increases the heat shock protein hsp70 in mouse pancreatic islets without impairing the glucose metabolism
74. Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1 beta-induced impaired beta-cell function
75. Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes
76. Transcriptional repression of the prointerleukin 1beta gene by heat shock factor 1
77. Inhibition of tumor necrosis factor-α transcription in macrophages exposed to febrile range temperature. A possible role for heat shock factor-1 as a negative transcriptional regulator
78. A high affinity HSF-1 binding site in the 5′-untranslated region of the murine tumor necrosis factor-α gene is a transcriptional repressor
79. The nuclear factor interleukin-6 (NF-IL6) and signal transducer and activator of transcription-3 (STAT-3) signalling pathways co-operate to mediate the activation of the hsp90β gene by inteleukin-6 but have opposite effects on its inducibility by heat shock
80. Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 an Hsp-90β gene promoters
81. c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity
82. Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: Possible link between endocrinosenescence and immunosenescence
83. Interleukin-6: A cytokine for gerontologists