Effects of quinine and quinidine on the transient outward and on the L-type Ca2+ current in rat ventricular cardiomyocytes

Pharmacology

Volumn 65, Issue 4, 2002, Pages 187-192

  Michel, Delia ^a   Wegener, Jörg W ^a   Nawrath, Hermann ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Binding sites; Channel state; Heart muscle; pH value; Stereoselectivity; Tertiary amines

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM ION; PROTON; QUINIDINE; QUININE; ANTIARRHYTHMIC AGENT; CALCIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENANTIOMER; EXTRACELLULAR SPACE; FEMALE; HEART MUSCLE; HEART VENTRICLE CONTRACTION; MALE; NONHUMAN; PATCH CLAMP; PH; PRIORITY JOURNAL; PROTON TRANSPORT; RAT; STIMULATION; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; HEART MUSCLE CELL; HEART VENTRICLE; IN VITRO STUDY; SPRAGUE DAWLEY RAT; STEREOISOMERISM;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; FEMALE; HEART VENTRICLES; HYDROGEN-ION CONCENTRATION; MALE; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; QUINIDINE; QUININE; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM;

EID: 0035996228     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000064342     Document Type: Article

References (28)

1. Quinidine
2. Drug treatment and prevention of malaria
3. Quinidine blocks cardiac sodium channels during opening and slow inactivation in guinea-pig papillary muscle
4. Quinidine-induced inhibition of transient outward current in cardiac muscle
5. K activation in guinea pig ventricular myocytes
6. Effects of quinidine on action potentials and ionic currents in isolated canine ventricular myocytes
7. Ca in single frog cardiac cells by quinidine, flecainide, ethmozin, and ethacizin
8. Antiarrhythmic activity of quinine in humans
9. Determinants of stereospecific binding of type I antiarrhythmic drugs to cardiac sodium channels
10. + channel: Role of S6 in antiarrhythmic drug binding
11. 2+-activated outward current in guinea-pig atrial myocytes
12. Calcium tolerant ventricular myocytes prepared by preincubation in a 'KB medium'
13. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
14. + current in rat ventricle
15. Stereoselective effects of the enantiomers, quinidine and quinine, on depolarization- and agonist-mediated responses in rat isolated aorta
16. Different mechanisms of the inhibition of the transient outward current in rat ventricular myocytes
17. Two components of transient outward current in canine ventricular myocytes
18. Nitrendipine block of cardiac calcium channels: High-affinity binding to the inactivated state
19. Kinetics and state-dependent effects of verapamil on cardiac L-type calcium channels
20. Antiarrhythmic agents: The modulated receptor mechanism of action of sodium and calcium channel-blocking drugs
21. Characterizing ion channel blockade with the guarded receptor hypothesis
22. Effects of flecainide, quinidine, and 4-aminopyridine on transient outward and ultrarapid delayed rectifier currents in human atrial myocytes
23. The pH-dependent rate of action of local anesthetics on the node of Ranvier
24. + channel currents by quinidine
25. Action of tertiary phenylalkylamines on cardiac transient outward current from outside the cell membrane
26. Potent block of volume-activated chloride currents in endothelial cells by the uncharged form of quinine and quinidine
27. Stereoselective renal tubular secretion of quinidine and quinine
28. Stereoselective interactions of organic cations with the organic cation transporter in OK cells