The genetics of alcoholism in Polynesians: Alcohol and aldehyde dehydrogenase genotypes in young men

Alcoholism: Clinical and Experimental Research

Volumn 26, Issue 7, 2002, Pages 949-955

  Chambers, Geoffrey K ^a   Marshall, Stephen J ^a   Robinson, Geoffrey M ^b   Maguire, Sean ^a   Newton Howes, Jan ^a   Chong, Nicola L ^a  

^a VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

^b WELLINGTON HOSPITAL   (New Zealand)

Author keywords

Alcohol and Aldehyde Dehydrogenase; Maori; New Zealand; Polynesian

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; ALDEHYDE DEHYDROGENASE;

ALCOHOL METABOLISM; ALCOHOLISM; ALLELE; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENETIC VARIABILITY; GENETICS; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEW ZEALAND; POLYNESIA; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; ABORIGINE; ASIAN; CAUCASIAN; COMPARATIVE STUDY; GENE FREQUENCY;

PIERINAE;

ALCOHOL DEHYDROGENASE; ALCOHOLISM; ALDEHYDE DEHYDROGENASE; ASIAN CONTINENTAL ANCESTRY GROUP; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; NEW ZEALAND; OCEANIC ANCESTRY GROUP; POLYNESIA;

EID: 0035995971     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2002.tb02626.x     Document Type: Article

References (55)

1. Levels of naturally occurring DNA polymorphism correlate with recombination rates in D. melanogaster
2. The colonization of the Pacific: Some current hypotheses
3. Genetic polymorphism of alcohol dehydrogenase in Europeans: The ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1
4. 2β2-Bern can be explained by a single base mutation
5. Genetic clues to dispersal in human populations: Retracing the past from the present
6. The genetics of human alcohol metabolism
7. Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients
8. The effect of deleterious mutations on neutral molecular variation
9. Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism
10. Alcohol dehydrogenase and aldehyde dehydrogenase genotypes and alcoholism among Taiwanese aborigines
11. Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele
12. Alcoholism among four aboriginal groups in Taiwan: High prevalences and their implications
13. Inference of population subdivision from VNTR distributions of New Zealanders
14. Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms
15. Genotyping study of alcohol dehydrogenase class I polymorphism in French patients with alcoholic cirrhosis
16. Genetic factors that reduce risk for developing alcoholism in animals and humans
17. Express train to Polynesia
18. Population bottlenecks in Polynesia revealed by minisatellites
19. Alcoholism susceptibility loci: Confirmation studies in a replicate sample and further mapping
20. ADH and ALDH genotype profiles in Caucasians with alcohol-related problems and controls
21. Distribution of ADH2 and ALDH2 genotypes in different populations
22. Language trees support the express-train sequence of Austronesian expansion
23. Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus
24. Genetic polymorphism of aldehyde dehydrogenase and its physiolggical significance to alcohol metabolism, in Isozymes: Structure
25. Aldehyde dehydrogenase genotypes in Japanese alcoholics
26. Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism
27. The effect of linkage on limits to artificial selection
28. CYP2E1 and ALDH2 genotypes and alcohol dependence in Japanese
29. Brain reward circuits in alcoholism
30. Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population
31. Alcohol-metabolizing enzyme polymorphisms and alcoholism in Japan
32. Genes and alcoholism: A preliminary report
33. Genotypes of alcohol-metabolizing enzymes in relation to alcoholic chronic pancreatitis in Japan
34. 2 differ by only one nucleotide
35. Alcohol and aldehyde dehydrogenase genotypes in Korsakoff syndrome
36. Alcohol and aldehyde dehydrogenase genotypes and drinking behavior of Chinese living in Shanghai
37. Characteristics of Japanese alcoholics with the atypical aldehyde dehydrogenase 2*2.1: A comparison of the genotypes ofALDH2, ADH2, ADH3, and cytochrome P-4502E1 between alcoholics and nonalcoholics
38. Association of the ADH2*2 allele with reduced ethanol consumption in Jewish men in Israel: A pilot study
39. Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism
40. Polymorphism of alcohol dehydrogenase, alcohol and aldehyde dehydrogenase activities: Implication in alcoholic cirrhosis in white patients
41. Genetic studies of alcoholism and substance dependence
42. The neurobiology of addiction
43. Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism
44. 2) with the disease
45. The hitch-hiking effect of a favourable gene
46. Genetic polymorphism of aldehyde dehydrogenase 2 in patients with upper aerodigestive tract cancer
47. Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders
48. Alcohol and aldehyde dehydrogenase genotypes in Chinese men
49. How alcohol and aldehyde dehydrogenase genes modify alcohol drinking, alcohol flushing and the risk of alcoholism
50. High salivary acetaldehyde after a moderate dose of alcohol in ALDH2-deficient subjects: Strong evidence for the local carcinogenic action of acetaldehyde
51. ADH genotypes and alcohol use and dependence in Europeans
52. Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification
53. Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: A multivariate analysis