Modulation of the negative inotropic effect of haloperidol by drugs with positive inotropic effects in isolated rabbit heart

Pharmacology

Volumn 66, Issue 1, 2002, Pages 19-25

  Hatip Al Khatib, Izzettin ^a   Bolukbaşi Hatip, Funda ^b  

^a PAMUKKALE UNIVERSITY   (Turkey)

^b Janssen Cilag Drugs   (Turkey)

Author keywords

Calcium; Haloperidol; Isolated heart; Negative inotropism

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM ION; DIGOXIN; DOBUTAMINE; DOPAMINE; HALOPERIDOL; NORADRENALIN; CALCIUM; CALCIUM CHANNEL STIMULATING AGENT; CARDIOTONIC AGENT; NEUROLEPTIC AGENT;

ANIMAL TISSUE; APPARATUS; ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; INOTROPISM; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; ANALYSIS OF VARIANCE; ANIMAL; CHEMICAL PHENOMENA; DOSE RESPONSE; HEART CONTRACTION; HEART LEFT VENTRICLE FUNCTION; HEART VENTRICLE PRESSURE; IN VITRO STUDY;

ANALYSIS OF VARIANCE; ANIMAL; ANTIPSYCHOTIC AGENTS, BUTYROPHENONE; BAY-K-8644; CALCIUM; CALCIUM CHANNEL AGONISTS; CARDIOTONIC AGENTS; DEPRESSION, CHEMICAL; DIGOXIN; DOBUTAMINE; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HALOPERIDOL; IN VITRO; MALE; MYOCARDIAL CONTRACTION; NOREPINEPHRINE; RABBITS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE; 3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ANIMALS; ANTIPSYCHOTIC AGENTS;

EID: 0035995465     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000063249     Document Type: Article

References (40)

1. Effect of magnesium sulfate on the haloperidol-induced QT prolongation assessed by the canine in vivo model under the monitoring of monophasic action potential
2. Antipsychotic agents and QT changes
3. Clustered lipid droplets in the endomyocardial biopsies from a patient with neuroleptic malignant syndrome
4. Toxic cardiomyopathy. The effect of antipsychotic-antidepressant drugs and calcium on myocardial protein degradation and structural integrity
5. Inotropic action of sigma receptor ligands in isolated cardiac myocytes from adult rats
6. In vivo evaluation of [(11)C]SA4503 as a PET ligand for mapping CNS sigma(1) receptors
7. Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in Xenopus oocytes
8. Haloperidol differentiates smooth muscle contraction induced by release of intracellulary stored Ca and by influx of extracellular Ca
9. Haloperidol on rat phrenic hemidiaphragm
10. Inhibition of P-type and N-type calcium channels by dopamine receptor antagonists
11. Inhibitory action of haloperidol, spiperone and SCH 23390 on calcium currents in rat retinal ganglia cells
12. 2+ influx and beating rate in cultured cardiac myocytes
13. Verapamil-induced hyperlactinemia and galactorrhea
14. Peculiar effects of isradipine and darodipine on the rat brain dopaminergic system
15. Some quantitative uses of drug antagonists
16. Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters
17. Functional classification of non-competitive antagonism in vas deferens
18. D,L-tetrahydropalmatine-produced hypotension and bradycardia in rats through the inhibition of central nervous dopaminergic mechanisms
19. Prolongation of QT interval in isolated feline hearts by antipsychotic drugs
20. Conduction disturbances associated with administration of butyrophenone antipsychotics in the critically ill: A review of the literature
21. Inhibition by haloperidol of adenosine 5′-triphosphate-evoked responses in rat pheochromocytoma cells
22. 2+ channels in rat and mouse cultured hippocampal pyramidal neurons
23. 2+ channels in hippocampal neurons
24. Effect of ethanol, haloperidol, and lorazepam on cardiac conduction and contraction
25. The agonist effect of dihydropyridine on calcium channels
26. Investigation of the negative inotropic effects of 17β-oestradiol in human isolated myocardial tissues
27. +-activated ATPase. A biochemical link to digitalis-induced inotropy
28. Digoxin activates sarcoplasmic reticulum Ca(2+)-release channels: A possible role in cardiac inotropy
29. Changes of the inotropic effect of digoxin induced by drugs and cations in isolated rabbit heart preparation
30. Dobutamine
31. Dobutamine: A new synthetic cardioactive sympathetic amine
32. Influence of contractile agonists on the mechanisms of endothelium-dependent relaxation in rat isolated mesenteric artery
33. Pressor responses to electrical and chemical stimulation of the rat brain A10 dopaminergic system
34. The inotropic effects of dopamine and its precursor levodopa on isolated human ventricular myocardium
35. 2(long-form) receptor co-transfected mouse fibroblast cell lines: Studies on intracellular calcium level
36. Receptors involved in the positive inotropic action induced by dopamine on the ventricle of a 7-day-old chick embryo heart
37. Central dopaminergic origin of bromocriptine-induced tachycardia in normotensive rats
38. Receptor for catecholamines responding to catechol which potentiates voltage-dependent calcium current in single cell from guinea-pig taenia caeci