Conformational analysis of bacterial cell wall peptides indicates how particular conformations have influenced the evolution of penicillin-binding proteins, β-lactam antibiotics and antibiotic resistance mechanisms

Journal of Molecular Recognition

Volumn 15, Issue 3, 2002, Pages 113-125

  Grail, Barry M ^a   Payne, John W ^a  

^a BANGOR UNIVERSITY   (United Kingdom)

Author keywords

Lactamase; Antibiotic resistance; Conformational analysis; Ligand binding; Molecular recognition; Peptide backbone torsions; Peptide conformers; Peptide transporters; Serine protease; Vancomycin

Indexed keywords

AMINO ACID SEQUENCE; ANTIBIOTICS, LACTAM; BACTERIA; BACTERIAL PROTEINS; CARRIER PROTEINS; CELL WALL; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; EVOLUTION, MOLECULAR; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDES; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T; VANCOMYCIN; ANTI-BACTERIAL AGENTS; BETA-LACTAMS; HEXOSYLTRANSFERASES; PENICILLIN-BINDING PROTEINS; PEPTIDYL TRANSFERASES;

BACTERIA (MICROORGANISMS);

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAM; CARBOXYPEPTIDASE TRANSPEPTIDASE; CARRIER PROTEIN; GLYCOSYLTRANSFERASE; PENICILLIN BINDING PROTEIN; PEPTIDE; PEPTIDYLTRANSFERASE; VANCOMYCIN;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM; CELL WALL; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG DESIGN; ENZYME SPECIFICITY; GENETICS; MOLECULAR EVOLUTION; PROTEIN CONFORMATION;

EID: 0035994076     PISSN: 09523499     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmr.566     Document Type: Article

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