Pinellic acid from the tuber of Pinellia ternata Breitenbach as an effective oral adjuvant for nasal influenza vaccine

International Immunopharmacology

Volumn 2, Issue 8, 2002, Pages 1183-1193

  Nagai, Takayuki ^a   Kiyohara, Hiroaki ^a   Munakata, Kaori ^a   Shirahata, Tatsuya ^a   Sunazuka, Toshiaki ^a   Harigaya, Yoshihiro ^a   Yamada, Haruki ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

Influenza vaccine; Mucosal immunity; Oral adjuvant; Pinellia ternata; Pinellic acid

Indexed keywords

ADJUVANT; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; INFLUENZA VACCINE; PINELLIA TERNATA EXTRACT; PINELLIC ACID; PLANT EXTRACT; SHO SEIRYU TO; UNCLASSIFIED DRUG; IMMUNOLOGICAL ADJUVANT;

ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG ISOLATION; DRUG POTENCY; DRUG PURIFICATION; DRUG SAFETY; FEMALE; HEMOLYSIS; INFLUENZA VACCINATION; INFRARED RADIATION; INOCULATION; LUNG LAVAGE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PINELLIA TERNATA; PLANT TUBER; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DRUG EFFECT; IMMUNOLOGY; INTRANASAL DRUG ADMINISTRATION; ISOLATION AND PURIFICATION; ORTHOMYXOVIRUS; PINELLIA;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ANIMAL; FEMALE; INFLUENZA VACCINE; MICE; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE; PINELLIA; PLANT EXTRACTS; PLANT TUBERS; ANIMALS; INFLUENZA VACCINES;

EID: 0035993220     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(02)00086-3     Document Type: Article

References (43)

1. Orthomyxoviruses
2. Cross-protection against influenza A virus infection by passively transferred respiratory tract IgA antibodies to different hemagglutinin molecules
3. Immunity to infection on secretory surfaces
4. Superior cross-protective effect of nasal vaccination to subcutaneous inoculation with influenza HA vaccine
5. Cross-protection against influenza virus infection afforded by trivalent inactivated vaccines inoculated intranasally with cholera toxin B subunit
6. Mucosal adjuvants
7. Treatment of respiratory diseases by Chinese medicine
8. In vivo anti-influenza virus activity of Kampo (Japanese herbal) medicine "Sho-seiryu-to" and its mode of action
9. In vivo anti-influenza virus activity of Kampo (Japanese herbal) medicine "Sho-seiryu-to": Effects on aged mice, against subtypes of A viruses and B virus, and therapeutic effect
10. Comparisons of serologic and febrile responses in humans to vaccination with influenza A viruses or their hemagglutinations
11. Acceleration of influenza virus clearance by Th1 cells in the nasal site of mice immunized intranasally with adjuvant-combined recombinant nucleoprotein
12. Standardized viral hemagglutination and hemagglutination-inhibition test. I. Standardization of erythrocyte suspensions
13. In vivo anti-influenza virus activity of Kampo (Japanese herbal) medicine "Sho-seiryu-to": Stimulation of mucosal immune system and effect on allergic pulmonary inflammation model mice
14. Onjisaponins, from the root of Polygala tenuifolia Willdenow, as effective adjuvants for nasal influenza and diphtheria-pertussis-tetanus vaccines
15. Measurement of antigen-specific mouse IgE by a fluorometric reverse (IgE-capture) ELISA
16. Kakkon-to suppressed interleukin-1α production responsive to interferon and alleviated influenza infection in mice
17. Structural features of fatty acid-amylose complexes
18. Effect of polymethylpolysaccharides on the hydrolysis of palmitoyl coenzyme A by a thioesterase from Mycobacterium smegmatis
19. Conformational changes associated with complex formation between a mycobacterial polymethylpolysaccharide and palmitic acid
20. Interaction of mycobacterial polymethylpolysaccharides with paranaric acid and palmitoyl-coenzyme A: Structural specificity and monomeric dissociation constants
21. General methods for determining absolute configurations of acyclic allylic alcohols
22. Further studies on the lethal effect of long-chain fatty acids on mycobacteria
23. Free fatty acids released from phospholipids are the major heat-stable hemolytic factor of Entamoeba histolytica trophozoites
24. Recombinant cholera toxin B subunit is not an effective mucosal adjuvant for oral immunization of mice against Helicobacter felis
25. The mucosal adjuvant effects of cholera toxin and immune-stimulating complexes differ in their requirement for IL-12, indicating different pathways of action
26. Whole cholera toxin and B subunit act synergistically as an adjuvant for the mucosal immune response of mice to keyhole limpet haemocyanin
27. Synergistic action of cholera toxin B subunit (and E. coli heat-labile toxin B subunit) and a trace amount of cholera whole toxin as an adjuvant for nasal influenza vaccine
28. Escherichia coli heat labile enterotoxin B subunits supplemented with a trace amount of the holotoxin as an adjuvant for nasal influenza vaccine
29. 18 fatty acid, a lignan and a new chromone
30. Unsaturated hydroxy fatty acids, the self defensive substances in rice plant against rice blast disease
31. The role of nasopharyngeal lymphoid tissue
32. New perspective vaccine development: Mucosal immunity to infection
33. Mucosal immunity to viruses
34. The structural basis for immunity in the respiratory tract
35. Nasal lymphoid tissue in the rat
36. Distribution of immunocompetent cells in normal nasal mucosa: Comparisons among germ-free, specific pathogen-free and conventional mice
37. The Waldeyer ring equivalent in the rat: A model for analysis of oronasopharyngeal immune responses
38. Mucosal vaccines: An overview
39. Gut-associated lymphoid tissue: Regulation of IgA B-cell development
40. Dendritic cells internalize vaccine adjuvant after intramusclar injection
41. The role of macrophages in particle translocation from lungs to lymph nodes
42. Adoptive transfer of fluorescence-labeled cells shows that resident peritoneal macrophages are able to migrate into specialized lymphoid organs and inflammatory sites in the mouse