Feline thyroid adenomas are in part associated with mutations in the Gsα gene and not with polymorphisms found in the thyrotropin receptor

Thyroid

Volumn 12, Issue 7, 2002, Pages 571-575

  Peeters, Marijke E ^a   Timmermans Sprang, Elpetra P M ^a   Mol, Jan A ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; RNA; THYROTROPIN RECEPTOR; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAT; CONTROLLED STUDY; GENE MUTATION; GENE SEQUENCE; GENETIC POLYMORPHISM; HYPERTHYROIDISM; NONHUMAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; THYROID ADENOMA; THYROTOXICOSIS; ADENOMA; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CODON; GENETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; REFERENCE VALUE; THYROID TUMOR;

ADENOMA; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CATS; CODON; DNA MUTATIONAL ANALYSIS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HYPERTHYROIDISM; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, THYROTROPIN; REFERENCE VALUES; THYROID NEOPLASMS;

EID: 0035992861     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: 10.1089/105072502320288410     Document Type: Article

References (21)

1. Hyperthyroidism in the cat: Ten cases
2. Historical, clinical and laboratory features of 126 hyperthyroid cats
3. Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas
4. Identification and functional characterization of two new somatic mutations causing constitutive activation of the thyrotropin receptor in hyperfunctioning autonomous adenomas of the thyroid
5. Congenital hyperthyroidism caused by a mutation in the thyrotropin-receptor gene
6. Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas
7. Somatic mutations in the VI transmembrane segment of the thyrotropin receptor constitutively activate cAMP signalling in thyroid hyperfunctioning adenomas
8. TSH receptor and disease
9. s α genes as a cause of toxic thyroid adenomas
10. Clonal origin of toxic thyroid nodules with constitutively activating thyrotropin receptor mutations
11. Gs alpha mutations in hyperfunctioning thyroid adenomas
12. Mutational analysis of the thyrotropin receptor gene in sporadic and familial feline thyrotoxicosis
13. Altered expression of G proteins in thyroid gland adenomas obtained from hyperthyroid cats
14. A simple salting out procedure for extracting DNA from human nucleated cells
15. Somatic mutations in the thyrotropin receptor gene and not in the Gsa protein gene in 31 toxic thyroid nodules
16. Detection of thyroid-stimulating hormone receptor and Gsα mutations in 75 toxic thyroid nodules by denaturating gradient gel electrophoresis
17. The inhibitory G protein. Gi-2 shows decreased expression in adenomatous thyroid tissue from hyperthyroid cats
18. Laser capture microscopy. Review
19. The thyrotropin receptor in thyroid diseases
20. Etiopathology of feline toxic nodular goiter
21. Over-expression of c-Ras in hyperplasia and adenomas of the feline thyroid gland: An immunohistochemical analysis of 34 cases