A mitogen-activated protein kinase is involved in the inotropic but not chronotropic actions of adrenoceptor agonists and endothelin-1

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 366, Issue 2, 2002, Pages 189-191

  Peters, Stephan L ^a   Sand, Carsten ^a   Michel, Martin C ^b   Pfaffendorf, Martin ^a   Van Zwieten, Pieter A ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Chronotropy; G protein coupled receptors; Heart; Inotropy; Mitogen activated protein kinases

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ENDOTHELIN 1; ISOPRENALINE; METHOXAMINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; 1,3 BUTADIENE DERIVATIVE; ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 1 ADRENERGIC RECEPTOR; ENZYME INHIBITOR; FLAVONOID; IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NITRILE; PYRIDINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CHRONOTROPISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; HEART LEFT ATRIUM; HEART RIGHT ATRIUM; INOTROPISM; ISOLATED HEART; MALE; NONHUMAN; RAT; ANALYSIS OF VARIANCE; ANIMAL; DRUG ANTAGONISM; DRUG POTENTIATION; HEART CONTRACTION; HEART RATE; METABOLISM; SIGNAL TRANSDUCTION; WISTAR RAT;

ADRENERGIC AGONISTS; ANALYSIS OF VARIANCE; ANIMAL; BUTADIENES; ENDOTHELIN-1; ENZYME INHIBITORS; FLAVONES; HEART RATE; IMIDAZOLES; ISOPROTERENOL; MALE; MAP KINASE SIGNALING SYSTEM; METHOXAMINE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIAL CONTRACTION; NITRILES; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; ANIMALS; FLAVONOIDS;

EID: 0035992684     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-002-0573-7     Document Type: Article

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