A recently described polymorphism in the CD28 gene on chromosome 2q33 is not associated with susceptibility to type 1 diabetes

European Journal of Immunogenetics

Volumn 29, Issue 4, 2002, Pages 347-349

  Wood, J P ^a   Pani, M A ^a   Bieda, K ^a,b   Meyer, G ^a   Usadel, K H ^a   Badenhoop, K ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b PAUL EHRLICH INSTITUT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; ABATACEPT; ANTIBODY CONJUGATE; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN;

ARTICLE; CHROMOSOME 2Q; CODON; CONTROLLED STUDY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INTRON; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; CHROMOSOME 2; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS;

ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION; CHROMOSOMES, HUMAN, PAIR 2; DIABETES MELLITUS, INSULIN-DEPENDENT; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMAN; POLYMORPHISM (GENETICS); SUPPORT, NON-U.S. GOV'T; ANTIGENS, CD; DIABETES MELLITUS, TYPE 1; HUMANS; IMMUNOCONJUGATES; POLYMORPHISM, GENETIC;

EID: 0035991737     PISSN: 09607420     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2370.2002.00328.x     Document Type: Article

References (20)

1. Is CTLA4 a master switch for peripheral T cell tolerance?
2. Human Ig superfamily CTLA-4 gene: Chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains
3. An Mse I RFLP in the human CTLA-4 promoter
4. CTLA-4 gene polymorphism is associated with predisposition to celiac disease
5. Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease
6. CTLA-4 alanine-17 confers genetic susceptibility to Grave's disease and to type 1 diabetes mellitus
7. B7.1 and B7.2 do not deliver identical costimulatory signals, since B7.2 and not B7.1 preferentially costimulates the initial production of IL-4
8. Covalent dimerization of CD28/CTLA-4 and oligomerization of CD80/CD86 regulate T cell costimulatory interactions
9. CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location
10. Common polymorphisms in the CTLA-4 and CD28 genes at 2q33 are not associated with asthma or atopy
11. Association staudies of CTLA-4, CD28, and ICOS gene polymorphisms with type diabetes in the Japanese population
12. Induction and maintenance of anergy in mature T cells
13. Human Cd28 and CTLA-4 Ig superfamily genes are located on chromosome 2 at bands q33-q34
14. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups
15. Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33
16. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry
17. Dinucleotide repeat polymorphism at the human CTLA-4 gene
18. Montecarlo tests for associations between disease and alleles at highly polymorphic loci
19. CD28 activation pathway regulates the production of multiple T cell-derived lymphokines/cytokines
20. Estimation of linkage disequilibrium in randomly mating populations