Tissue distribution of [14C]sucrose octasulfate following oral administration to rats

Pharmaceutical Research

Volumn 19, Issue 6, 2002, Pages 838-844

  Hiebert, Linda M ^a   Wice, Sandra M ^a   Ping, Tilly ^a   Hileman, Ronald E ^b   Polat, Tülay ^b   Linhardt, Robert J ^b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Endothelium; Gastrointestinal absorption; Oral; Rats; Sucrose octasulfate

Indexed keywords

SUCRALFATE; CARBON; DRUG DERIVATIVE; SUCROSE; SUCROSE OCTASULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY DISTRIBUTION; COLON; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; DUODENUM; ENDOTHELIUM; GASTROINTESTINAL ABSORPTION; ILEUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH; STOMACH TUBE; ULCER; ANIMAL; CHEMISTRY; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; TISSUE DISTRIBUTION; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; CARBON RADIOISOTOPES; MALE; RATS; RATS, WISTAR; SUCROSE; TISSUE DISTRIBUTION;

EID: 0035990857     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016161001013     Document Type: Article

References (24)

1. Stress ulcer prophylaxis: Do critically ill patients need it?
2. Uncomplicated peptic ulcer disease: An overview of formation and treatment principles
3. Duodenal ulcer: Discovery of a new mechanism and development of angiogenic therapy that accelerates healing
4. Role of vascular factors, including angiogenesis, in the mechanisms of action of sucralfate
5. Emerging anticoagulant and thrombolytic drugs
6. Dextran sulfate is poorly absorbed after oral administration
7. The oral bio-availability of pentosan polysulphate sodium in healthy volunteers
8. Treatment of experimentally induced caval thrombosis with oral low molecular weight heparin and delivery agent in a porcine model of deep venous thrombosis
9. Evidence from endothelium of gastric absorption of heparin and of dextran sulfates 8000
10. Antithrombotic efficacy in a rat model of the low molecular weight heparin, reviparin sodium, administered by the oral route
11. Pharmacological actions of sulodexide
12. Pentosan polysulfate therapy for chronic nonbacterial prostatitis (chronic pelvic pain syndrome category IIIA): A prospective multicenter clinical trial
13. Orally administered dextran sulfate is absorbed in HIV-positive individuals
14. The heparin target organ-the endothelium: Studies in a rat model
15. 14C-labeled porcine intestinal mucosal heparin following administration to rats by the oral route
16. Heparin uptake on endothelium
17. Determination of absolute amounts of heparin and of dextran sulfate in plasma in microgram quantities
18. Antithrombotic activity of oral unfractionated heparin
19. Lowering of plasma viscosity by the oral administration of the glycosaminoglycan sulodexide in patients with peripheral vascular disease
20. Scintigraphic evaluation of dogs with acute synovitis after treatment with glucosamine hydrochloride and chondroitin sulfate
21. Efficacy and tolerability of oral chondrotin sulfate as a symtomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis
22. Antithrombotic activity of orally administered low molecular weight heparin (logiparin) in a rat model