Selective and sustained occupancy of prostatic α1-adrenoceptors by oral administration of KMD-3213 and its plasma concentration in rats

Journal of Pharmacy and Pharmacology

Volumn 54, Issue 7, 2002, Pages 975-982

  Okura, T ^a   Yamada, S ^a   Abe, Y ^b   Kimura, R ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b KISSEI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 HYDROXYBUTYL) 5 [2 [[2 [[2 [(2,2,2 TRIFLUOROETHYL)OXY]PHENYL]OXY]ETHYL]AMINO]]PROPYL 2,3 DIHYDRO 1H INDOLE 7 CARBOXAMIDE; ALPHA 1 ADRENERGIC RECEPTOR; KMD 3278; PRAZOSIN; SILODOSIN; UNCLASSIFIED DRUG; INDOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BLADDER OBSTRUCTION; BRAIN CORTEX; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INHIBITION; HEART; NONHUMAN; PROSTATE; PROSTATE HYPERTROPHY; RAT; RECEPTOR BINDING; SPLEEN; SUBMANDIBULAR GLAND; TARGET ORGAN; TISSUE; ANIMAL; MALE; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; URETHRA OBSTRUCTION;

ADMINISTRATION, ORAL; ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INDOLES; MALE; PROSTATE; PROSTATIC HYPERPLASIA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; SUBMANDIBULAR GLAND; TISSUE DISTRIBUTION; URETHRAL OBSTRUCTION; ANIMALS;

EID: 0035990601     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/002235702760089108     Document Type: Article

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