Effects of pregnancy on insulin receptor in liver, skeletal muscle and adipose tissue of rats

Gynecological Endocrinology

Volumn 16, Issue 3, 2002, Pages 193-205

  Gonzalez C G ^a   Alonso, A ^a   Balbin M ^a   Diaz F ^a   Fernandez S ^a   Patterson, A M ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

Author keywords

17 estradiol; Insulin receptor; Insulin resistance; Progesterone; Rat

Indexed keywords

ESTRADIOL; INSULIN RECEPTOR; PROGESTERONE; PROTEIN TYROSINE KINASE; INSULIN; MESSENGER RNA;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HORMONE ACTION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN PHOSPHORYLATION; RAT; SKELETAL MUSCLE; ANIMAL; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; NORTHERN BLOTTING; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PREGNANCY COMPLICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA PROBE; SERODIAGNOSIS; TIME; WESTERN BLOTTING; WISTAR RAT;

ADIPOSE TISSUE; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION; INSULIN; INSULIN RESISTANCE; LIVER; MUSCLE, SKELETAL; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PRECIPITIN TESTS; PREGNANCY; PREGNANCY COMPLICATIONS; PROGESTERONE; RATS; RATS, WISTAR; RECEPTOR, INSULIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA PROBES; RNA, MESSENGER; TIME FACTORS;

EID: 0035989545     PISSN: 09513590     EISSN: None     Source Type: Journal    
DOI: 10.1080/gye.16.3.193.205     Document Type: Article

References (55)

1. Insulin sensitivity and β-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes
2. Mechanism of cellular insulin resistance in human pregnancy
3. Insulin receptor binding and tyrosine kinase activity in skeletal muscle from normal pregnant women and women with gestational diabetes
4. Synthesis-secretion coupling of insulin: Effect of pregnancy and lactation
5. Maternal diet and insulin secretion in islets of lactating, nonlactating and young rats
6. Effects of pregnancy on glucose metabolism in glucose intolerant 'B' Wistar rats
7. Adaptation of islets of Langerhans to pregnancy: Increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion
8. Temporal changes in insulin resistance and secretion in 24-h-fasted conscious pregnant rats
9. Dexamethasone induces insulin receptor synthesis in cultured rat hepatocytes
10. Pregnancy-induced insulin resistance in the rat: Assessment by glucose clamp technique
11. In vivo glucose utilization rates and insulin sensitivity in tissues of pregnant rats
12. Pregnancy-induced insulin resistance in liver and skeletal muscles of the conscious rabbit
13. Carbohydrate and lipid metabolism during normal pregnancy: Relationship to gestational hormone action
14. In vivo insulin resistance during pregnancy in the rat
15. Endocrine regulation of metabolic homeostasis during pregnancy
16. Insulin receptor structure and function in normal and pathological conditions
17. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
18. The insulin signaling system
19. Expression and function of IRS-1 in insulin signal transmission
20. Effect of aging on insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in liver and muscle of rats
21. Effect of glucagon on insulin receptor substrate-1 (IRS-1) phosphorylation and association with phosphatidylinositol 3-kinase (PI 3-kinase)
22. Modulation of early steps in insulin action in the liver and muscle of epinephrine treated rats
23. Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinase
24. The metabolic regulation and vesicular transport of GLUT4, the major insulin-responsive glucose transporter
25. Effects of steroid and lactogenic hormones on islets of Langerhans: A new hypothesis for the role of pregnancy steroids in the adaptation of islets to pregnancy
26. The effects of oestrogen and progesterone on insulin sensitivity in female rats
27. Relative effects of pregnancy and corticosterone administration on skeletal muscle metabolism in the rat
28. Insulin resistance, secretion and metabolism in users of oral contraceptives
29. Defects in insulin signal transduction in liver and muscle of pregnant rats
30. Defects in carbohydrate metabolism in oral contraceptive users without apparent metabolic risk factors
31. Effects of sex hormones on insulin receptor mass and compartmentalization in rat liver
32. Role of 17-β-estradiol and/or progesterone on insulin sensitivity in the rat: Implications during pregnancy
33. Glucose utilization and insulin action in adult rats submitted to prolonged food restriction
34. In vivo insulin sensitivity in the rat determined by euglycemic clamp
35. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
36. Regulation of insulin receptor mRNA splicing in rat tissues. Effect of fasting, aging and diabetes
37. A rapid and sensitive method for the quantitation of microgram quantities utilizing the principle of protein dye binding
38. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Procedure and some applications
39. Role of 17-β-estradiol and progesterone on glucose homeostasis: Effects of food restriction (50%) in pregnant and non pregnant rats
40. Pathogenesis of type-2 (non-insulin-dependent) diabetes mellitus: Candidates for a signal transmitter defect causing insulin resistance of the skeletal muscle
41. Regulation of hepatic insulin receptor tyrosine kinase in rat models of mild insulin resistance
42. Induction of insulin resistance by androgens and estrogens
43. Effect of diet change on insulin action: Difference between muscles and adipocytes
44. Insulin action in obese non-insulin-dependent diabetics and in their isolated adipocytes before and after weight loss
45. Effect of streptozocin-induced diabetes on insulin-receptor tyrosine kinase activity in obese Zucker rats
46. Insulin degradation: Mechanism, products and significance
47. Pregnancy in rats and food restriction (50%): Insulin response in relation to serum lipids and lipoprotein levels
48. Adipocyte insulin action during the normal menstrual cycle
49. Menstrual cycle associated changes in glucose metabolism in women with IDDM
50. Intravenous glucose tolerance test-derived insulin sensitivity changes during the menstrual cycle
51. Glucocorticoid regulation of insulin receptor gene transcription in MI-9 cultured lymphocytes
52. Glucocorticoids increase insulin binding and the amount of insulin-receptor mRNA in human cultured lymphocytes