Vasopeptidase inhibition in a canine model of exercise-induced left ventricular dysfunction

Clinical and Experimental Pharmacology and Physiology

Volumn 29, Issue 8, 2002, Pages 696-703

  Holzgrefe, Henry H ^a,b   Arthur, Susan R ^a   Powell, James R ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Angina; Angiotensin converting enzyme inhibitors; Collateral circulation; Contractile function; Dog; Haemodynamics; Ischaemia

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FOSINOPRILAT; GLYCERYL TRINITRATE; MEMBRANE METALLOENDOPEPTIDASE; OMAPATRILAT; SODIUM CHLORIDE; VASOPEPTIDASE INHIBITOR; PROTEINASE INHIBITOR; PYRIDINE DERIVATIVE; THIAZEPINE DERIVATIVE;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DOG; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; EXERCISE; FEMALE; HEART FUNCTION; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE OXYGEN CONSUMPTION; HEART RATE; HEART VENTRICLE HYPERTROPHY; NONHUMAN; OXYGEN SUPPLY; ST SEGMENT; TREADMILL EXERCISE; TREATMENT OUTCOME; WORKLOAD; ANIMAL; COMPARATIVE STUDY; DRUG ANTAGONISM; ENZYMOLOGY; HEART LEFT VENTRICLE FUNCTION; HEMODYNAMICS; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMAL; COMPARATIVE STUDY; DISEASE MODELS, ANIMAL; DOGS; FEMALE; HEMODYNAMICS; NEPRILYSIN; NITROGLYCERIN; PHYSICAL CONDITIONING, ANIMAL; PROTEASE INHIBITORS; PYRIDINES; THIAZEPINES; VENTRICULAR DYSFUNCTION, LEFT; ANIMALS; HEMODYNAMIC PROCESSES;

EID: 0035988915     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.2002.03718.x     Document Type: Article

References (43)

1. Rationale for ACE inhibition as an anti-ischaemic therapy
2. Bradykinin-mediated cardiovascular protective actions of ACE inhibitors. A new dimension in anti-ischaemic therapy?
3. Bradykinin accounts for improved postischemic function and decreased glutathione release of guinea pig heart treated with the angiotensin-converting enzyme inhibitor ramiprilat
4. Inhibition of angiotensin-converting enzyme increases the nitric oxide levels in canine ischemic myocardium
5. + channels in the protective effect of ACE inhibition against ischemic myocardial injury
6. Force-length relationship in dogs as a measure of protective effect of imidapril on regional myocardial ischemia and reperfusion injury
7. Effect of an endothelin receptor antagonist and an angiotensin converting enzyme inhibitor on metabolism and contraction in the ischemic and reperfused rabbit heart
8. Cardioprotective effect of angiotensin-converting enzyme inhibition against hypoxia/reoxygenation injury in cultured rat cardiac myocytes
9. Effect of neutral endopeptidase 24.11 inhibition on myocardial ischemia/reperfusion injury. The role of kinins
10. Neutral endopeptidase in the heart. Neutral endopeptidase inhibition prevents isoproterenol-induced myocardial hypoperfusion in rats by reducing bradykinin degradation
11. Endopeptidase inhibitors decrease myocardial ischemia/reperfusion injury in an in vivo rabbit model
12. Combined inhibition of neutral endopeptidase and angiotensin converting enzyme in cardiomyopathic hamsters with compensated heart failure
13. Bradykinin-induced preconditioning in patients undergoing coronary angioplasty
14. Kallidin- and bradykinin-degrading pathways in human heart: Degradation of kallidin by aminopeptidase M-like activity and bradykinin by neutral endopeptidase
15. Kinin-mediated coronary nitric oxide production contributes to the therapeutic action of angiotensin-converting enzyme and neutral endopeptidase inhibitors and amlodipine in the treatment in heart failure
16. Effects of beta-blockade on regional myocardial flow and function during exercise
17. Elimination of exercise-induced regional myocardial dysfunction by a bradycardiac agent in dogs with chronic coronary stenosis
18. Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion of dogs
19. Effects of nitroglycerin on cardiac function and regional blood flow distribution in conscious dogs
20. Repeated measurements and multiple comparisons in cardiovascular research
21. Experimental exercise-induced ischemia: Drug therapy can eliminate regional dysfunction and oxygen supply-demand imbalance
22. Effects of a calcium-entry blocker (diltiazem) on regional myocardial flow and function during exercise in conscious dogs
23. The effect of pericardiectomy on maximal oxygen consumption and maximal cardiac output in untrained dogs
24. Visceral blood flow distribution during exercise to exhaustion in conscious dogs
25. Oxygen consumption and hemodynamic responses during graded treadmill exercise in the dog
26. Nitroglycerin dilates coronary collateral vessels during exercise after blockade of endogenous NO production
27. The effects of nitroglycerin on regional myocardial contractile dysfunction produced by treadmill exercise or isoprenaline stimulation in dogs
28. Effects of catecholamines, exercise, and nitroglycerin on the normal and ischemic myocardium in conscious dogs
29. Oral nitrates: More than symptomatic therapy in coronary artery disease?
30. Effect of intravenous nitroglycerin on collateral blood flow and infarct size in the conscious dog
31. Comparison of effects of nifedipine and nitroglycerin on large and small coronary arteries and cardiac function in conscious dogs
32. The effects of nitroglycerin on exercise-induced regional myocardial contractile dysfunction are not diminished by pretreatment with dihydroergotamine
33. Efficacy of nitroglycerin in stress-induced regional myocardial dysfunction is dependent on the chosen model: Investigations in anesthetized and conscious dogs
34. Angiotensin converting enzyme inhibition in chronic stable angina: Effects on myocardial ischaemia and comparison with nifedipine
35. Treatment of chronic stable angina pectoris with angiotensin converting enzyme inhibition: A randomized, placebo-controlled, double-blind cross-over study
36. Converting enzyme inhibition in coronary artery disease: A randomized, placebo-controlled trial with benazepril
37. Acute effects of the angiotensin converting enzyme inhibitor ramipril in patients with coronary heart disease
38. Discordance of anti-ischemic and hemodynamic effects of captopril in stable coronary artery disease
39. ACE inhibition with cilazapril improves myocardial perfusion to the ischemic regions during exercise: A pilot study
40. Effects of angiotensin-converting enzyme inhibition on exercise-induced angina and ST segment depression in patients with microvascular angina
41. The variable effects of angiotensin converting enzyme inhibition on myocardial ischaemia in chronic stable angina
42. Vasopeptidase inhibitors: Incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides