Nitroglycerin dilates coronary collateral vessels during exercise after blockade of endogenous NO production

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 277, Issue 3 46-3, 1999, Pages

  Klassen, Christopher L ^a   Traverse, Jay H ^a   Bache, Robert J ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Angiogenesis; Blood flow; Collateral circulation; Endothelium derived factors

Indexed keywords

GLYCERYL TRINITRATE; GUANYLATE CYCLASE; MICROSPHERE; N(G) NITROARGININE; NITRIC OXIDE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; CORONARY ARTERY COLLATERAL CIRCULATION; CORONARY ARTERY DILATATION; DOG; EXERCISE; HEART FUNCTION; HEMODYNAMICS; NONHUMAN; PRIORITY JOURNAL;

EID: 0032886983     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1999.277.3.h918     Document Type: Article

References (28)

1. Altman, J., D. Dulas, T. Pavek, D. Laxson, D. C. Homans, and R. J. Bache. Endothelial function in well-developed canine coronary collateral vessels. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H567-H572, 1993.
2. Altman, J. D., J. Kinn, D. J. Duncker, and R. J. Bache. Effect of inhibition of nitric oxide formation on coronary blood flow during exercise in the dog. Cardiovasc. Res. 28: 119-124, 1994.
3. Aoki, M., K. Sakai, S. Koyanagi, A. Takeshita, and M. Nakamura. Effect of nitroglycerin on coronary collateral function during exercise evaluated by quantitative analysis of thallium 201 single photon emission computed tomography. Am. Heart J. 121: 1361-1366, 1991.
4. Bache, R. J., and J. S. Schwartz. Myocardial blood flow during exercise after gradual coronary occlusion in the dog. Am. J. Physiol. 245 (Heart Circ. Physiol. 14): H131-H138, 1983.
5. Cox, D. A., J. A. Vita, C. B. Treasure, R. D. Fish, R. W. Alexander, P. Ganz, and A. P. Selwyn. Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans. Circulation 30: 458-465, 1989.
6. Duncker, D. J., and R. J. Bache. Inhibition of nitric oxide production aggravates myocardial hypoperfusion during exercise in the presence of a coronary artery stenosis. Circ. Res. 74: 629-640, 1994.
7. Fam, W. M., and M. McGregor. Effect of coronary vasodilator drugs on retrograde flow in areas of chronic myocardial ischemia. Circ. Res. 15: 355-365, 1964.
8. Fedor, J. M., J. Rembert, D. McIntosh, and J. C. Greenfield, Jr. Effects of exercise- and pacing-induced tachycardia on coronary collateral flow in the awake dog. Circ. Res. 46: 214-220, 1980.
9. Frank, M., K. Harris, K. Ahlin, and F. J. Klocke. Endothelium-derived relaxing factor (nitric oxide) has a tonic vasodilating action on coronary collateral vessels. J. Am. Coll. Cardiol. 27: 658-663, 1996.
10. Franklin, D., D. McKown, M. McKown, J. Hastley, and M. Caldwell. Development and regression of coronary collaterals induced by repeated, reversible ischemia in dogs (Abstract). Federation Proc. 40: 339, 1981.
11. Fujita, M., K. Yamanishi, T. Hirai, K. Miwa, M. Ejiri, H. Asanoi, and S. Sasayama. Significance of collateral circulation in reversible left ventricular asynergy by nitroglycerin in patients with relatively recent myocardial infarction. Am. Heart J. 120: 521-528, 1990.
12. Fujita, M., K. Yamanishi, M. Inoko, and K. Miwa. Preferential dilation of recipient coronary arteries of the collateral circulation by intracoronary administration of nitroglycerin. J. Am. Coll. Cardiol. 24: 631-635, 1994.
13. Fujita, M., K. Yamanishi, K. Miwa, and M. Inoko. Variable responses of highly stenotic coronary arteries and collateral circulation to intracoronary injection of nitroglycerin in patients with chronic effort angina. Coron. Artery Dis. 5: 525-529, 1994.
14. Gwirtz, P. A. Construction and evaluation of a coronary catheter for chronic implantation in dogs. J. Appl. Physiol. 60: 720-726, 1986.
15. Harrison, D. G. Endothelial dysfunction in atherosclerosis. Basic Res. Cardiol. 89: 87-102, 1994.
16. Harrison, D. G., and J. N. Bates. The nitrovasodilators new ideas about old drugs. Circulation 87: 1461-1467, 1993.
17. Hautamaa, P. J., X. Dai, D. C. Homans, and R. J. Bache. Vasomotor activity of moderately well-developed canine coronary collateral circulation. Am. J. Physiol. 256 (Heart Circ. Physiol. 25): H890-H897, 1989.
18. Lambert, P. R., D. S. Hess, and R. J. Bache. Effect of exercise on perfusion of collateral-dependent myocardium in dogs with chronic coronary artery occlusion. J. Clin. Invest. 59: 1-7, 1977.
19. Lamontagne, D., U. Pohl, and R. Busse. Mechanical deformation of vessel wall and shear stress determine the basal release of endothelium-derived relaxing factor in the intact rabbit coronary vascular bed. Circ. Res. 70: 123-130, 1992.
20. Noris, M., M. Morigi, R. Donadelli, S. Aiello, M. Foppolo, M. Todeschini, S. Orisio, G. Remuzzi, and A. Remuzzi. Nitric oxide synthesis by cultured endothelial cells is modulated by flow conditions. Circ. Res. 76: 536-543, 1995.
21. Patterson, R. E., and E. S. Kirk. Apparent improvement in canine collateral myocardial blood flow during vasodilation depends on criteria used to identify ischemic myocardium. Circ. Res. 47: 108-116, 1980.
22. Pupita, G., D. Mazzara, M. Centanni, C. Rimatori, G. F. Ferretti, P. Dessi-Fulgheri, P. Russo, and A. Rappelli. Ischemia in collateral-dependent myocardium: effects of nifedipine and diltiazem in man. Am. Heart J. 126: 86-94, 1993.
23. Quebbeman, B. B., C. L. Klassen, and R. J. Bache. Exercise fails to cause vasodilation of coronary collateral vessels. J. Cardiovasc. Pharmacol. 31: 821-827, 1998.
24. Schwartz, J. S., K. W. Baran, and R. J. Bache. Effect of a stenosis on exercise-induced dilation of large coronary arteries. Am. Heart J. 119: 520-524, 1990.
25. Selke, F. W., P. R. Myers, J. N. Bates, and D. G. Harrison. Influence of vessel size on the sensitivity of porcine coronary microvessels to nitroglycerin. Am. J. Physiol. 258 (Heart Circ. Physiol. 27): H515-H520, 1990.
26. Traverse, J. H., J. Altman, J. Kinn, D. J. Duncker, and R. J. Bache. Effect of β-adrenergic receptor blockade on blood flow to collateral-dependent myocardium during exercise. Circulation 91: 1560-1567, 1995.
27. Traverse, J. H., J. W. Kinn, C. L. Klassen, D. J. Duncker, and R. J. Bache. Nitric oxide inhibition impairs blood flow during exercise in hearts with collateral-dependent myocardial region. J. Am. Coll. Cardiol. 31: 67-74, 1998.
28. Wang, J., M. S. Wolin, and T. H. Hintze. Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs. Circ. Res. 73: 829-838, 1993.