APE/Ref-1 is controlled by both redox and cAMP-dependent mechanisms in rat thyroid cells

Hormone and Metabolic Research

Volumn 34, Issue 6, 2002, Pages 303-310

  Tell, G ^b   Pines, A ^b   Pandolfi, M ^a   D'Elia, A V ^a   Donnini, D ^a   Lonigro, R ^a   Manzini, G ^b   Russo, D ^c   Di Loreto, C ^a   Damante, G ^a  

^a UNIVERSITY OF UDINE   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

APE Ref 1; cAMP; Nuclear Translocation; Redox Potential; Thyroid

Indexed keywords

CYCLIC AMP; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN; PROTEIN APE; REDOX EFFECTOR FACTOR 1; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR PAX8; UNCLASSIFIED DRUG; APEX1 PROTEIN, RAT; CALCIUM; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; LYASE; THYROTROPIN;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DNA BINDING; DNA REPAIR; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; THYROID CELL; TRANSCRIPTION REGULATION; ANIMAL; BIOSYNTHESIS; CELL LINE; CELL NUCLEUS; CHEMISTRY; CYTOPLASM; DRUG EFFECT; METABOLISM; THYROID GLAND; TRANSPORT AT THE CELLULAR LEVEL; ULTRASTRUCTURE;

ANIMAL; BIOLOGICAL TRANSPORT; CALCIUM; CARBON-OXYGEN LYASES; CELL LINE; CELL NUCLEUS; CYCLIC AMP; CYTOPLASM; OXIDATION-REDUCTION; RATS; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; THYROID GLAND; THYROTROPIN; ANIMALS; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE;

ALOCASIA MACRORRHIZOS; ANIMALIA;

EID: 0035988646     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-33258     Document Type: Article

References (37)

1. Redox regulation of cellular activation
2. The structure and functions of the HAP1/Ref-1 protein
3. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals
4. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice
5. Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo
6. Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation
7. An "environment to nucleus" signaling system operates in B lymphocytes: Redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation
8. 2 generation and I-uptake by thyrotropin through the cyclic adenosine 3′, 5′-monophosphate cascade
9. Oxidative stress and anti-oxidant metabolites in patients with hyperthyroidism: Effect of treatment
10. TSH controls Ref-1 nuclear translocation in thyroid cells
11. Expression and subcellular localization of human AP endonuclease 1 (HAP1/Ref-1) protein: A basis for its role in human disease
12. Ref-1 controls pax-8 DNA-binding activity
13. Thyroid cells in culture
14. Redox potential controls the structure and DNA binding activity of the paired domain
15. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
16. The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer
17. Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers
18. Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes
19. Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors
20. Increase in Ref-1 mRNA and protein by thyrotropin in rat thyroid FRTL-5 cells
21. Formation of thyroid hormones
22. 2 generation in isolated thyroid follicles enhance protein iodination
23. Glutathione and its role in cellular functions
24. Thyroid-specific gene expression is differentially influenced by intracellular glutathione level in FRTL-5 cells
25. ++ down regulate thyrotropin receptor gene expression by a mechanism different from the cAMP signal
26. Norepinephrine, unlike ATP, induces all-or-none increase in cytosolic calcium in thyroid cells. The role of inositol-trisphosphate-sensitive stores and calcium channels
27. 2+ and iodide efflux induced by thyrotropin and by the stimulation of alpha 1-adrenergic receptors in cultured rat thyroid cells
28. Transcriptional activation of apurinic/apyrimidinic endonuclease (Ape, Ref-1) by oxidative stress requires CREB
29. 2 production
30. Role of the cyclic adenosine 3′,5′-monophosphate and the phosphatidylinositol-Ca2+ cascades in mediating the effects of thyrotropin and iodide on hormone synthesis and secretion in human thyroid slices
31. 2+ signaling followed by phospholipase-A2 activation and potentiated by an adenosine derivative
32. A redof factor protein, ref-1, is involved in negative gene regulation by extracellular calcium
33. Redox regulation of thyroid-transcription factors, Pax-8 and TTF-1, is involved in their increased DNA-binding activities by thyrotropin in rat thyroid FRTL-5 cells
34. 2+ mobilization in single human thyroid cells
35. A unique combination of transcription factors controls differentiation of thyroid cells
36. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity
37. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NFAT4