Identification of human hepatic cytochrome P450 sources of N-alkylprotoporphyrin IX after interaction with porphyrinogenic xenobiotics, implications for detection of xenobiotic-induced porphyria in humans

Drug Metabolism and Disposition

Volumn 30, Issue 7, 2002, Pages 788-794

  Lavigne, James A ^a   Nakatsu, Kanji ^a   Marks, Gerald S ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 ETHYL 1,4 DIHYDRO 2,6 DIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER; ALLYLISOPROPYLACETAMIDE; COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; PORPHYRINOGEN; PROTOPORPHYRIN; SYDNONE DERIVATIVE; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; CONTROLLED STUDY; FLUOROMETRY; HUMAN; IN VITRO STUDY; LIVER MICROSOME; MALE; NONHUMAN; PORPHYRIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPECIES DIFFERENCE; ANIMAL; ENZYMOLOGY; ISOLATION AND PURIFICATION; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMAL; CYTOCHROME P-450 ENZYME SYSTEM; HUMAN; MALE; MICROSOMES, LIVER; PORPHYRIA; PORPHYRINOGENS; PROTOPORPHYRINS; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; XENOBIOTICS; ANIMALS; HUMANS; PORPHYRIAS;

ANIMALIA; INSECTA; UNIDENTIFIED BACULOVIRUS;

EID: 0035987889     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.7.788     Document Type: Article

References (20)

1. Ferrochelatase-inhibitory and porphyrin-inducing properties of 3.5- diethyoxycarbonyl-l,4-dihydro-2,4,6-trimethylpyridine and its analogues in chick embryo liver cells
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3. Conversion of liver haem into N-substituted porphyrins or green pigments: Nature of the substituent at the pyrrole nitrogen atom
4. Cytochrome P450 and its interaction with the heme biosynthetic pathway
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8. cDNA-expressed human cytochrome P450 isozymes. Inactivation by porphyrinogenic xenobiotics
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11. N-Methylprotoporphyrin IX: Chemical synthesis and identification as the green pigment produced by 3.5-diethoxycarbonyl-1.4-dihydrocollidine treatment
12. Inhibition of cytochrome P450 enzymes
13. Inactivation of cytochrome P450 during catalytic oxidation of a 3-[(arylthio)-ethyl]sydnone: N-vinyl heme formation via insertion into the Fe-N bond
14. Destruction of cytochrome P450 by allylisopro-pylacetamide is a suicidal process
15. The allylisopropylacetamide and novonal prosthetic heme adducts
16. Integrated cytochrome P450 reaction phenotyping. Attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes
17. Gender differences in N-alkyl protoporphyrin IX production in rats after the administration of porphyrinogenic xenobiotics
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