Formation of N-alkylprotoporphyrin IX after interaction of porphyrinogenic xenobiotics with rat liver microsomes

Journal of Pharmacological and Toxicological Methods

Volumn 42, Issue 3, 1999, Pages 107-113

  Wong, Simon G W ^a   Marks, Gerald S ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Cytochrome P450; Dihydropyridine; Experimental porphyria; Mechanism based inactivation; N alkylprotoporphyrin IX; Sydnone

Indexed keywords

1 AMINOBENZOTRIAZOLE; 4 ETHYL 1,4 DIHYDRO 2,6 DIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER; COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; DEXAMETHASONE; FERROCHELATASE; PROTOPORPHYRIN; SYDNONE DERIVATIVE; XENOBIOTIC AGENT;

ALKYLATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ENZYME MECHANISM; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER MICROSOME; MALE; MOLECULAR INTERACTION; NONHUMAN; PORPHYRIN METABOLISM; RAT; XENOBIOTIC METABOLISM;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; ISOENZYMES; MALE; MICROSOMES, LIVER; PORPHYRIAS; PORPHYRINS; PROTOPORPHYRINS; RATS; RATS, SPRAGUE-DAWLEY; XENOBIOTICS;

ANIMALIA;

EID: 0033305724     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(99)00050-7     Document Type: Article

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