DNA repair protein levels vis-à-vis anticancer drug resistance in the human tumor cell lines of the National Cancer Institute drug screening program

Anti-Cancer Drugs

Volumn 13, Issue 5, 2002, Pages 511-519

  Xu, Zhiyuan ^a   Chen, Zhong Ping ^a   Malapetsa, Areti ^a   Alaoui Jamali, Moulay ^a   Bergeron, Josée ^a   Monks, Anne ^a   Myers, Timothy G ^a   Mohr, Gérard ^a   Sausville, Edward A ^a   Scudiero, Dominic A ^a   Aloyz, Raquel ^a   Panasci, Lawrence C ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Bifunctional alkylating agent; DNA repair; Drug resistance; Endogenous protein; National Cancer Institute human cell line panel; Nucleotide excision repair; Xeroderma pigmentosum complementary group D

Indexed keywords

1 (2 CHLOROETHYL) 3 (2,6 DIOXO 3 PIPERIDYL) 1 NITROSOUREA; 5,6 DIHYDROAZACITIDINE; 6 O METHYLGUANINE; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; BACTOBOLIN; BRUCEANTIN; CARBAZOLE DERIVATIVE; CHROMOMYCIN A3; CYSTEINE DERIVATIVE; DACTINOMYCIN; DIDEMNIN A; DIGLYCOALDEHYDE; DOXORUBICIN; ECHINOMYCIN; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; GENE PRODUCT; HOMOHARRINGTONINE; MACBECIN I; MITHRAMYCIN; MITOFLAXONE; PACLITAXEL; PHYLLANTHOSIDE; PIBENZIMOL; PROTEIN XPA; PROTEIN XPB; RAD51 PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINBLASTINE SULFATE; XERODERMA PIGMENTOSUM GROUP D PROTEIN; DNA BINDING PROTEIN; ENDONUCLEASE; ERCC1 PROTEIN, HUMAN; ERCC2 PROTEIN, HUMAN; HELICASE; PROTEIN; TRANSCRIPTION FACTOR; XERODERMA PIGMENTOSUM GROUP A PROTEIN; XPA PROTEIN, HUMAN; XPBC ERCC 3 PROTEIN; XPBC-ERCC-3 PROTEIN;

ARTICLE; CANCER CELL CULTURE; CANCER CENTER; CYTOTOXICITY; DNA REPAIR; DRUG MECHANISM; DRUG RESISTANCE; DRUG SCREENING; DRUG SENSITIVITY; EUKARYOTE; EXCISION REPAIR; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; CELL CULTURE; FEMALE; GENETICS; MALE; METABOLISM; NEOPLASM; PHYSIOLOGY;

ANTINEOPLASTIC AGENTS, ALKYLATING; DNA REPAIR; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMAN; MALE; NEOPLASMS; PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED; DNA HELICASES; ENDONUCLEASES; HUMANS; TRANSCRIPTION FACTORS; XERODERMA PIGMENTOSUM GROUP A PROTEIN; XERODERMA PIGMENTOSUM GROUP D PROTEIN;

EID: 0035987079     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200206000-00010     Document Type: Article

References (40)

1. Nucleotide excision repair genes as determinants of cellular sensitivity to cyclophosphamide analogs
2. 6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)- 1-nitrosourea
3. 6-methylguanine-DNA methyltransferase-mediated innate chloroethylnitrosourea resistance in human tumor cell lines
4. Clinical drug resistance: The role of factors other than P-glycoprotein
5. Resistance of human cervical carcinoma cells to tumor necrosis factor correlates with their increased sensitivity to cisplatin: Evidence of a role for DNA repair and epidermal growth factor receptor
6. Cisplatin and DNA repair in cancer chemotherapy
7. Apoptosis and cancer chemotherapy
8. Increased mRNA levels of xeroderma pigmentosum complementation group B (XPB) and Cockayne's syndrome complementation group B (CBS) without increased mRNA levels of multi-drug-resistance gene (MDRI) or metallothionein-II (MT-II) in platinum-resistant human ovarian cancer tissues
9. 6-methylguanine
10. Antineoplastic drug resistance in brain tumors
11. Mammalian DNA damage-inducible genes associated with growth arrest and apoptosis
12. Mammalian nucleotide excision repair
13. Repair of UV-damaged DNA by mammalian cells and Saccharomyces cerevisiae
14. Cellular responses to cisplatin: The roles of DNA-binding proteins and DNA repair
15. Correlation of chloroethylnitrosourea resistance with ERCC-2 expression in human tumor cell lines as determined by quantitative competitive polymerase chain reaction
16. Excision repair cross-complementing rodent repair deficiency gene 2 expression and chloroethylnitrosourea resistance in human glioma cell lines
17. ERCC-1 and ERCC-2 expression in malignant tissues from ovarian cancer patients
18. Sensitivity of CHO mutant cell lines with specific defects in nucleotide excision repair to different anti-cancer agents
19. Defective DNA cross-link removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents
20. Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
21. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
22. New colorimetric cytotoxicity assay for anticancer-drug screening
23. Purification of the transcription/repair factor TFIIH and evaluation of its associated activities in vitro
24. Mammalian DNA nucleotide excision repair reconstituted with purified protein components
25. Detection and measurement of nucleotide excision repair synthesis by mammalian cells extracts in vitro
26. Display and analysis of patterns of differential activity of drugs against human tumor cell lines: Development of mean graph and COMPARE algorithm
27. Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen
28. Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen
29. Prediction of biochemical mechanisms of action from the in vitro antitumor screen of the National Cancer Institute
30. Use of the Kohonen self-organizing map to study the mechanisms of action of chemotherapeutic agents
31. The two major spore DNA repair pathways, nucleotide excision repair and spore photoproduct lyase, are sufficient for the resistance of Bacillus subtilis spores to artificial UV-C and UV-B but not to solar radiation
32. Xeroderma pigmentosum, Cockayne's syndrome, helicases, and DNA repair: What's the relationship?
33. Negative superhelicity promotes ATP-dependent binding of yeast RAD3 protein to ultraviolet-damaged DNA
34. Molecular cloning and biological characterization of a human gene, ERCC-2, that corrects the nucleotide excision repair defect in CHO UV5 cells
35. Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours
36. The contribution of homologous recombination in preserving genomic integrity in mammalian cells
37. Functional nucleotide excision repair is required for the preferential removal of N-ethylpurines from the transcribed strand of the dihydrofolate reductase gene of Chinese hamster ovary cells
38. DNA repair capacity: Inconsistency between effect of over-expression of five NER genes and the correlation of mRNA levels in primary lymphocytes
39. Increased nucleotide excision repair in cisplatin-resistant ovarian cancer cells
40. XPD might play an important role in DNA repair