Sensitivity of CHO mutant cell lines with specific defects in nucleotide excision repair to different anti-cancer agents

International Journal of Cancer

Volumn 66, Issue 6, 1996, Pages 779-783

  Damia, Giovanna ^a   Imperatori, Luigi ^a   Stefanini, Miria ^b   D'Inacai, Maurizio ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b Ist Genet Biochemica E   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; CISPLATIN; DIMETHYL SULFATE; DOXORUBICIN; MELPHALAN; METHYLNITRONITROSOGUANIDINE; N,N DIMETHYLACETAMIDE; RACHELMYCIN; TALLIMUSTINE;

ANIMAL CELL; ARTICLE; CELL MUTANT; CHO CELL; CONTROLLED STUDY; DNA DAMAGE; DNA DENATURATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SENSITIVITY; EXCISION REPAIR; GENETIC COMPLEMENTATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CHO CELLS; CISPLATIN; CRICETINAE; CRICETULUS; DISTAMYCINS; DNA DAMAGE; DNA HELICASES; DNA REPAIR; DNA, NEOPLASM; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; ENDONUCLEASES; INDOLES; LEUCOMYCINS; MELPHALAN; METHYLNITRONITROSOGUANIDINE; NITROGEN MUSTARD COMPOUNDS; NUCLEOTIDES; PROTEINS; RADIATION TOLERANCE; SULFURIC ACID ESTERS; TRANSCRIPTION FACTORS; ULTRAVIOLET RAYS; XERODERMA PIGMENTOSUM GROUP D PROTEIN;

EID: 0029890253     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960611)66:6<779::AID-IJC12>3.0.CO;2-Z     Document Type: Article

References (22)

1. BOHR, V.A., SMITH, CA., OKUMOTO, D.S. and HANAWALT, P.C., DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Cell, 40, 359-369 (1985).
2. BOOTSMA, D., The genetic defect in DNA repair deficiency syndromes. EACR - Muhlbock Memorial Lecture, 1993. Europ. J. Cancer, 29A, 1482-1488 (1993).
3. BRAMSON, J. and PANASCI, L.C., Effect of ERCC-1 overexpression on sensitivity of Chinese hamster ovary cells to DNA damaging asents. Cancer Res., 53, 3237-3240 (1993).
4. BROGGINI, M., COLEY, H.M., MONGELLI, N., PESENTI, E., WYATT, M D., HARTLEY, J.A. and D'INCALCI, M., DNA sequence specific adenine alkylation by the novel antitumor drug Tallimustine (FCE 24517) a benzoylnitrogen mustard derivative of Distamycin, Nucl. Acids Res., 23, 81-87 (1995).
5. COLLINS, A.R., Mutant rodent cell lines sensitive to ultraviolet light. ionizing radiation and cross-linking agents: a comprehensive survey of genetic and biochemical characteristics. Mutat. Res., 293, 99-118 (1993).
6. DABHOLKAR, M., BOSTICK BRUTON, F., WEBER, C., BOHR, V.A., EGWUAGU, C. and REED, E., ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients. J. nat. Cancer Inst., 84, 1512-1517 (1992).
7. DABHOLKAR, M., VIONNET, J., BOSTICK BRUTON, F., Yu, J.J. and REED, E., Messenger RNA levels of XPAC and ERCC1 in ovarian cancer tissue correlate with response to platinum-based chemotherapy. J clin. Invest., 94, 703-708 (1994).
8. DAMIA, G., IMPERATORI, L., CITTI, L., MARIANI, L. and D'INCALCI, M., 3-methyladenine-DNA-glycosylase and O6-alkylguanine-DNA-alkyl-transferase activities and sensitivity to alkylating agents in human cancer cell lines. Brit. J. Cancer, (1995). (In press).
9. DRAPKIN, R., REARDON, J.T., ANSARI, A., HUANG, J.C., ZAWEL, L., AHN, K., SANCAR, A. and REINBERG, D., Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II. Nature (Lond.), 368., 769-772 (1994).
10. HANAWALT, P. and MELLON, I., Stranded in an active gene. Preferential repair of lesions in transcribed DNA strands is coupled to transcription. A gene that is defective in Cockayne's syndrome encodes what seems to be a coupling factor. Curr. Biol., 3, 67-69 (1993).
11. HOEIJMAKERS, J.H.J., Human nucleotide excision repair syndromes: molecular clues to unexpected intricacies. Europ. J. Cancer, 30A, 1912-1921 (1994).
12. KELNER, M.J., MCMORRIS, T.C., ESTES. L., RUTHERFORD, M., MONTOYA, M., GOLDSTEIN, J., SAMSON, K., STARR, R. and TAETLE, R., Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells. Unusually high sensitivity of ERCC2 and ERCC3 DNA helicase-deficient mutants in comparison to other chemotherapeutic agents. Biochem. Pharmacol, 48, 403-409 (1994).
13. LARMINAT, F. and BOHR, V.A., Role of the human ERCC-I gene in gene-specific repair of cisplatin-induced DNA damage. Nucl. Acids Res., 22, 3005-3010 (1994).
14. LEE, K.B., PARKER, RJ., BOHR, V., CORNELISON, T. and REED. E., Cisplatin sensitivity/resistance in UV repair-deficient Chinese hamster ovary cells of complementation groups 1 and 3. Carcmogenesis, 14, 2177-2180 (1993).
15. O'DONOVAN, A., SCHERLY, D., CLARKSON, S.G. and WOOD, R.D., Isolation of active recombinant XPG protein, a human DNA repair endonuclease. J. biol. Chem., 269, 15965-15968 (1994).
16. OLLER, A.R., FIJALKOWSKA, I.J., DUNN, R.L. and SCHAAPER. R.M., Transcription-repair coupling determines the strandedness of ultraviolet mutagenesis in Escherichia coli. Proc. nat. Acad. Sci. (Wash.), 89, 11036-11040 (1992).
17. SCHAEFFER, L., ROY, R., HUMBERT, S., MONCOLLIN, V.. VERMEULEN, W., HOEIJMAKERS, J.H., CHAMBON, P. and EGLY, J.M., DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor. Science (Wash.), 260, 58-63 (1993).
18. THOMPSON, L.H., SALAZAR, E.P., BROOKMAN, K.W., COLLINS, C.C., STEWART, S.A., BUSCH, D.B., and WEBER, C.A. Recent progress with the DNA repair mutants of Chinese hamster ovary cells. J. Cell Set Suppl 6, 97-100 (1987).
19. TROELSTRA, C., HESEN, W., BOOTSMA, D. and HOEIJMAKERS, J.H., Structure and expression of the excision repair gene ERCC6. involved in the human disorder Cockayne's syndrome group B. Nucl. Acids Res., 21, 419-426 (1993).
20. VAN GOOL A.J., VERHAGE, R., SWAGEMAKERS, S.M., VAN DE PUTTTE, P., BROUWER, J., TROELSTRA, C., BOOTSMA, D. and HOEIJMAKERS, J.H., RAD26, the functional S. cerevisiae homolog of the Cockayne syndrome B gene ERCC6. EMBO J., 13, 5361-5369 (1994).
21. VAN VUUREN, A.J., APPELDOORN, E., ODLJK H., YASUI, A., JASPERS, N.G., BOOTSMA, D. and HOEUMAKERS, J.H., Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and Xeroderma pigmentosum group F. EMBO J., 12, 3693-3701 (1993).
22. WEEDA, G., VAN HAM, R.C.A., VERMEULEN, W., BOOTSMA, D., VAN DER EB, A.J. and HOEIJMAKERS, J.H.J., A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders Xeroderma pigmentosum and Cockayne's syndrome. Cell 62, 777-791 (1990).