Sub-lethal concentrations of activated complement increase rat lymphocyte glutamine utilization and oxidation while lethal concentrations cause death by a mechanism involving ATP depletion

Cell Biochemistry and Function

Volumn 20, Issue 3, 2002, Pages 183-190

  Bacurau, R F P ^a,b   O'Toole, C E ^c   Newsholme, P ^c   Costa Rosa, L F B P ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UniFMU Centro Universitário

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Cell death; Complement; Glucose; Glutamine; Lymphocytes; Metabolism

Indexed keywords

ADENOSINE TRIPHOSPHATE; CITRATE SYNTHASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTAMINASE; GLUTAMINE; HEXOKINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; ZYMOSAN; COMPLEMENT; GLUCOSE; OXYGEN;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL METABOLISM; CITRIC ACID CYCLE; COMPLEMENT ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOLYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; GLUCOSE UTILIZATION; GLYCOLYSIS; HUMAN; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; OXIDATION; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; RAT; ANIMAL; APOPTOSIS; CELL SURVIVAL; DOSE RESPONSE; METABOLISM; NECROSIS; WISTAR RAT;

ADENOSINE TRIPHOSPHATE; ANIMAL; APOPTOSIS; CELL DEATH; CELL SURVIVAL; COMPLEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; GLUCOSEPHOSPHATE DEHYDROGENASE; GLUTAMINASE; GLUTAMINE; HEXOKINASE; HUMAN; LYMPHOCYTES; MALE; NECROSIS; OXYGEN; PENTOSEPHOSPHATE PATHWAY; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; ANIMALS; COMPLEMENT SYSTEM PROTEINS; HUMANS; PENTOSE PHOSPHATE PATHWAY;

EID: 0035986721     PISSN: 02636484     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbf.943     Document Type: Article

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