Sulfur mustard exposure enhances Fc receptor expression on human epidermal keratinocytes in cell culture: Implications for toxicity and medical countermeasures

Cell Biology and Toxicology

Volumn 14, Issue 4, 1998, Pages 261-266

  Cowan, F M ^a   Broomfield, C A ^a   Smith, W J ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Fc receptor; Keratinocytes; Protease; Sulfur mustard; Vesication

Indexed keywords

CD16 ANTIGEN; CD32 ANTIGEN; FC RECEPTOR; MUSTARD GAS; PROTEINASE;

ARTICLE; BASAL CELL; BLISTER; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INFLAMMATION; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION;

CELLS, CULTURED; CHEMICAL WARFARE AGENTS; EPIDERMIS; HUMANS; KERATINOCYTES; MUSTARD GAS; RECEPTORS, IGG;

EID: 0031902093     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007430907869     Document Type: Article

References (43)

1. Ali ST, Ray P. Identification and partial characterization of mustard stimulated protease in normal human epidermal keratinocytes. Proceedings of the 1996 Medical Defense Bioscience Review. Aberdeen Proving Ground, Maryland: U.S. Army Medical Research Institute of Chemical Defense; 1996; 122:705-14.
2. Arroyo CM, Von Tersch RL, Broomfield CA. Activation of alpha-human tumour necrosis factor (TNF-α) by human monocytes (TNP-1) exposed to 2-chloroethyl ethyl sulphide (H-MG). Hum Exp Toxicol. 1995;14:547-53.
3. Bauer RM, Young GD, Keeler JR. Tachykinins and pulmonary edema following acute phosgene exposure in guinea-pigs. J Am Coll Toxicol. 1996; 15(Supplment 2):S99-112.
4. 3. J Leukocyte Biol. 1995;58: 256-62.
5. Bongiovanni R, Millard CB, Schulz SM, Romano JM. Estimation of neutrophil infiltration into hairless guinea pig skin treated with 2,2′-dichlorodiethyl sulfide. Proceedings of the 1993 Medical Defense Bioscience Review. Aberdeen Proving Ground, Maryland: 1996;1:389-95. [ADA275667].
6. Cambier JC. Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM). J Immunol. 1995;155:3281-5.
7. Casillas RP, Santai CT, France J. Cytokines as potential biomarkers of cutaneous vesication injury. FASEB J. 1996a;10:A421.
8. Casillas RP, Smith KJ, Lee RB, Castrejon LR, Stemler FW. Effect of topically applied drugs against HD-induced cutaneous injury in the mouse ear edema model. Proceedings of the 1996 Medical Defense Bioscience Review. Aberdeen Proving Ground, Maryland: U.S. Army Medical Research Institute of Chemical Defense; 1996b;122:801-9.
9. Cowan FM. A method of treating cellular Fc receptor mediated immune disorders. U.S. Patent 5,189,014, Feb. 23, 1993 (original application Serial No. 99,741 filed December 3, 1979).
10. Cowan FM, Broomfield CA. Putative roles of inflammation in the dermatopathology of sulfur mustard. Cell Biol Toxicol. 1993;9:201-13.
11. Cowan FM, Madsen JM. The role of immunoglobulin binding factors in the pathogenesis and therapy of AIDS. Medical Hypothesis. 1994;43:172-6.
12. Cowan FM, Broomfield CA, Smith WJ. Effect of sulfur mustard on protease activity in human peripheral blood lymphocytes. Cell Biol Toxicol. 1991;7:239-48.
13. Cowan FM, Broomfield CA, Smith WJ. Inhibition of sulfur mustard-increased protease activity by niacinamide, N-acetyl-L-cysteine or dexamethasone. Cell Biol Toxicol. 1992;8:9-133.
14. Cowan FM, Yourick JJ, Hurst CG, Broomfield CA, Smith WJ. Sulfur mustard-increased proteolysis following in vitro and in vivo exposures. Cell Biol Toxicol. 1993;9:253-61.
15. Cowan FM, Bongiovanni R, Broomfield CA, Yourick JJ, Smith WJ. Sulfur mustard increases elastase-like activities in homogenates of hairless guinea pig skin. J Toxicol Cutan Ocular Toxicol. 1994a;13:221-9.
16. Cowan FM, Bongiovanni R, Broomfield CA, Schulz SM, Smith WJ. Phenidone and hydroxyurea reduce sulfur mustard-increased proteolysis in hairless guinea pig skin. J Toxicol Cutan Toxicol. 1994b;14:265-72.
17. Cowan FM, Anderson DR, Broomfield CA, Byers S, Smith WJ. Biochemical alterations in rat lung lavage fluid following acute sulfur mustard inhalation. II. Increases in proteolytic activity. Inhalat Toxicol. 1996;9:53-61.
18. Fridman WH. Fc receptors and immunoglobulin binding factors. FASEB J. 1991;5:2684-90.
19. Graham JS, Bryant MA, Braue EH. Effect of sulfur mustard on mast cells in hairless guinea pig skin. J Toxicol Cutan Ocular Toxicol. 1994;13:47-54.
20. Higuchi K, Kajiki A, Nakamura M et al. Protease released in organ culture by acute inflammatory lesions produced in vivo in rabbit skin by sulfur mustard: hydrolysis of synthetic peptide substrates for trypsin-like and chymotrypsin-like enzymes. Inflammation. 1988;12:311-34.
21. Hornschuh B, Hamm H, Wever S et al. Treatment of 16 patients with bullus pemphigoid with oral tetracycline and niacinamide and topical clobetasol. J Am Acad Dermatol. 1997;36: 101-3.
22. Hunyadi J, Simon M Jr, Dobozy A. Immune-associated surface markers of human keratinocytes. Immunol Lett. 1992;31: 209-16.
23. 3 and calcipotriol decrease extracellular plasminogen activator activity in cultured keratinocytes. J Invest Dermatol. 1993;101:706-12.
24. Kurt EM, Schafer RJ, Broomfield CA, Kahler DW, Arroyo CM. Immunologic cytokine expression in human keratinocytes after exposure to sulfur mustard. J Am Coll Toxicol. 1996;15(supplement 2):532-5.
25. Linsay CD, Hambrook JL, Smith CN, Rice P. Histological assessment of the effects of percutaneous exposure of sulfur mustard in an in vitro human skin system and the therapeutic properties of protease inhibitors. Proceedings of the 1996 Medical Defense Bioscience Review. Aberdeen Proving Ground, Maryland: U.S. Army Medical Research Institute of Chemical Defense; 1996;122:899-908.
26. Nunes IP, Johannesen AC, Matre R, Kristoffersen T. Epithelial expression of HLA class II antigens and Fc receptors in patients with adult periodontitis. J Clin Periodontol. 1994; 21:256-32.
27. Papirmeister B, Gross CL, Meier HL, Petrali JP, Johnson JB. Molecular basis for mustard-induced vesication. Fund Appl Toxicol. 1985;5:S134-49.
28. Papirmeister B, Feister AJ, Robinson SI, Ford RD. Medical defense against mustard gas: toxic mechanisms and pharmacological implications. Boston: CRC Press; 1991:1-359.
29. Pechura CM, Rail DP (eds). Veterans at risk, the health effects of mustard gas and lewisite. Washington D.C.: National Academy Press; 1993.
30. Petrali JP, Ogelsby SB, Hamilton TA, Mills KR. Ultrastructural and immunohistochemistry correlates of mustard gas skin lesions. Proceedings of the Histological Society of America Spring Meeting, May 14.
31. Ravetch JV. Fc receptors: rubor redux. Cell. 1994;78:553-60.
32. Sandor M, Lynch RG. The biology and pathology of Fc receptors. J Clin Immunol. 1993;4:237-46.
33. Schlager JJ, Smith WJ, Hart BW. Sulfur mustard (HD) stress gene induction in transformed HEP G2 cells. Proceedings of the 1996 Medical Defense Bioscience Review. Aberdeen Proving Ground, Maryland: U.S. Army Medical Research Institute of Chemical Defense; 1996; 122:1055-61.
34. Sinclair NR StC. Antibody-antigen complexes: biological consequences. In: Encyclopedia of human biology. New York: Academic Press; 1991;1:297-305.
35. Singh S, Natarajan J, Aggarwall BB. Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a potent inhibitor of nuclear transcription factor-kB activation by diverse agents. J Immunol. 1996;157:4412-20.
36. Smith WJ, Cowan FM, Broomfield CA. Increased proteolytic activity in human epithelial cells following exposure to sulfur mustard. FASEB J. 1991;5:A828.
37. Sylvestre DL, Ravetch JV. Fc receptors initiate the arthus reaction: redefining the inflammatory cascade. Science. 1994;265:1095-8.
38. Tigalonowa M, Bjerke JR, Livden JK, Matre R. The distribution of FcRI, FcRII, and FcRIII on Langerhans' cells and keratinocytes in normal skin. Acta Dermatol Venereol (Stockh). 1990;70:385-90.
39. Wallace PK, Howell AL, Fanger MW. Role of Fc receptors in cancer and infectious disease. J Leukocyte Biol. 1994;55: 816-26.
40. Watson JV. Flow cytometry data analysis. New York: Cambridge University Press; 1992:44-6.
41. Wiedow HA, Wiese F, Streit V, Kalm C, Christophers E. Lesional elastase activity in psoriasis, contact dermatitis, and atopic dermatitis. J Invest Dermatol. 1992;98:306-9.
42. Wilhelms OH, Linssen MJ, Lipponer L, Seilnaacht W. Nimesulide, indomethacin, BW755 C, phenidon, mepacrin and nedocromil inhibit the activation of human and rat leukocytes. Int J Tiss React. 1990;XII:101-6.
43. Yourick JJ, Clark CR, Mitcheltree LW. Niacinamide pretreatment reduces microvesicle formation in hairless guinea pigs cutaneously exposed to sulfur mustard. Fund Appl Toxicol. 1991;17:533-42.